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    Znrf4 zinc and ring finger 4 [ Mus musculus (house mouse) ]

    Gene ID: 20834, updated on 14-Nov-2024

    Summary

    Official Symbol
    Znrf4provided by MGI
    Official Full Name
    zinc and ring finger 4provided by MGI
    Primary source
    MGI:MGI:1341258
    See related
    Ensembl:ENSMUSG00000044526 AllianceGenome:MGI:1341258
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    spzn; Ssrzf1; 1700094M01Rik
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in negative regulation of cell cycle; negative regulation of nucleotide-binding activity oligomerization domain containing 2 signaling pathway; and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytoplasm. Orthologous to human ZNRF4 (zinc and ring finger 4). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

    See Znrf4 in Genome Data Viewer
    Location:
    17 D; 17 29.37 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56818248..56819483, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56511248..56512483, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33211 Neighboring gene STARR-positive B cell enhancer ABC_E10963 Neighboring gene predicted gene, 33258 Neighboring gene TINCR ubiquitin domain containing Neighboring gene scaffold attachment factor B2

    Genomic regions, transcripts, and products

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding  
    enables protein binding PubMed 
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase activity  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    is_active_in endoplasmic reticulum  
    is_active_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane  
    is_active_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane  

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase ZNRF4
    Names
    RING-type E3 ubiquitin transferase ZNRF4
    sperizin
    spermatid specific RING zinc finger 1
    zinc/RING finger protein 4
    NP_035613.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011483.2NP_035613.2  E3 ubiquitin-protein ligase ZNRF4 precursor

      See identical proteins and their annotated locations for NP_035613.2

      Status: VALIDATED

      Source sequence(s)
      AK005843, BY104804
      Consensus CDS
      CCDS28906.1
      UniProtKB/Swiss-Prot
      Q9DAH2, Q9WTN2
      Related
      ENSMUSP00000059715.3, ENSMUST00000052211.4
      Conserved Domains (2) summary
      cd02123
      Location:19156
      PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
      pfam13639
      Location:207252
      zf-RING_2; Ring finger domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      56818248..56819483 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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