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    PSEN1 presenilin 1 [ Microcebus murinus (gray mouse lemur) ]

    Gene ID: 105858213, updated on 13-Mar-2024

    Summary

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    Gene symbol
    PSEN1
    Gene description
    presenilin 1
    See related
    Ensembl:ENSMICG00000017923
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Microcebus murinus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes; Cheirogaleidae; Microcebus
    Also known as
    PS1; PS-1; PSNL1
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See PSEN1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    101 current Mmur_3.0 (GCF_000165445.2) 3 NC_033662.1 (20206297..20278100)
    100 previous assembly Mmur_2.0 (GCF_000165445.1) Unplaced Scaffold NW_012195498.1 (509596..590875)

    Chromosome 3 - NC_033662.1Genomic Context describing neighboring genes Neighboring gene zinc finger FYVE-type containing 1 Neighboring gene thioredoxin-dependent peroxide reductase, mitochondrial-like Neighboring gene RNA binding motif protein 25 Neighboring gene nucleolar protein of 40 kDa pseudogene Neighboring gene nucleolar protein of 40 kDa-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning, sequencing, and brain expression of the presenilin 1 gene in Microcebus murinus. Calenda A, et al. Biochem Biophys Res Commun, 1996 Nov 12. PMID 8920931

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables aspartic endopeptidase activity, intramembrane cleaving IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables beta-catenin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cadherin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Notch receptor processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in amyloid precursor protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in amyloid-beta metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in membrane protein ectodomain proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in smooth endoplasmic reticulum calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in ciliary rootlet IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in dendritic shaft IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuromuscular junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    presenilin-1
    Names
    Presenilin-1
    presenilin I
    NP_001296874.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001309945.1 → NP_001296874.1  presenilin-1

      See identical proteins and their annotated locations for NP_001296874.1

      Status: PROVISIONAL

      Source sequence(s)
      Z71333
      UniProtKB/Swiss-Prot
      P79802
      UniProtKB/TrEMBL
      A0A8C5XF92
      Related
      ENSMICP00000016318.3, ENSMICT00000017923.3
      Conserved Domains (1) summary
      pfam01080
      Location:76 → 457
      Presenilin; Presenilin

    RefSeqs of Annotated Genomes: Microcebus murinus Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmur_3.0 Primary Assembly

    Genomic

    1. NC_033662.1 Reference Mmur_3.0 Primary Assembly

      Range
      20206297..20278100
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P79802.1 GenPept UniProtKB/Swiss-Prot:P79802

    Gene LinkOut

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