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    MUC15 mucin 15, cell surface associated [ Homo sapiens (human) ]

    Gene ID: 143662, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MUC15provided by HGNC
    Official Full Name
    mucin 15, cell surface associatedprovided by HGNC
    Primary source
    HGNC:HGNC:14956
    See related
    Ensembl:ENSG00000169550 MIM:608566; AllianceGenome:HGNC:14956
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAS3; MUC-15; PASIII
    Summary
    Predicted to be located in Golgi lumen and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in thyroid (RPKM 49.6), skin (RPKM 13.7) and 5 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MUC15 in Genome Data Viewer
    Location:
    11p14.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (26559032..26572263, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (26699699..26712907, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (26580579..26593810, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene anoctamin 3 Neighboring gene ANO3 antisense RNA 1 Neighboring gene uncharacterized LOC105376598 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:26544561-26545120 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:26545121-26545680 Neighboring gene uncharacterized LOC124902648 Neighboring gene uncharacterized LOC107987160

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cell surface associated protein mucin 15 (MUC15) is elevated in preeclampsia. Nguyen A, et al. Placenta, 2023 Sep 7. PMID 37531748
    2. High Expression of MUC15 Is Correlated with Poor Prognosis of Pancreatic Cancer and Promotes Migration, Invasion, and Chemo-Resistance In Vitro. Wang S, et al. Med Sci Monit, 2020 Oct 14. PMID 33051432, Free PMC Article
    3. Mucin 15 is expressed in human placenta and suppresses invasion of trophoblast-like cells in vitro. Shyu MK, et al. Hum Reprod, 2007 Oct. PMID 17720698
    4. Targeting MUC15 Protein in Cancer: Molecular Mechanisms and Therapeutic Perspectives. Zhang S, et al. Curr Cancer Drug Targets, 2020. PMID 32479243
    5. MUC15 inhibits cancer metastasis via PI3K/AKT signaling in renal cell carcinoma. Yue Y, et al. Cell Death Dis, 2020 May 7. PMID 32382053, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cell surface associated protein mucin 15 (MUC15) is elevated in preeclampsia.
      Title: Cell surface associated protein mucin 15 (MUC15) is elevated in preeclampsia.
    2. Downregulation of MUC15 by miR-183-5p.1 promotes liver tumor-initiating cells properties and tumorigenesis via regulating c-MET/PI3K/AKT/SOX2 axis.
      Title: Downregulation of MUC15 by miR-183-5p.1 promotes liver tumor-initiating cells properties and tumorigenesis via regulating c-MET/PI3K/AKT/SOX2 axis.
    3. MUC15 loss facilitates epithelial-mesenchymal transition and cancer stemness for prostate cancer metastasis through GSK3beta/beta-catenin signaling.
      Title: MUC15 loss facilitates epithelial-mesenchymal transition and cancer stemness for prostate cancer metastasis through GSK3β/β-catenin signaling.
    4. Targeting MUC15 Protein in Cancer: Molecular Mechanisms and Therapeutic Perspectives.
      Title: Targeting MUC15 Protein in Cancer: Molecular Mechanisms and Therapeutic Perspectives.
    5. MUC15 promotes growth and invasion of glioma cells by activating Raf/MEK/ERK pathway.
      Title: MUC15 promotes growth and invasion of glioma cells by activating Raf/MEK/ERK pathway.
    6. High Expression of MUC15 Is Correlated with Poor Prognosis of Pancreatic Cancer and Promotes Migration, Invasion, and Chemo-Resistance In Vitro.
      Title: High Expression of MUC15 Is Correlated with Poor Prognosis of Pancreatic Cancer and Promotes Migration, Invasion, and Chemo-Resistance In Vitro.
    7. MUC15 inhibits cancer metastasis via PI3K/AKT signaling in renal cell carcinoma.
      Title: MUC15 inhibits cancer metastasis via PI3K/AKT signaling in renal cell carcinoma.
    8. Frameshift mutations of MUC15 gene is associated with gastric and colorectal cancers.
      Title: Frameshift mutations of MUC15 gene in gastric and its regional heterogeneity in gastric and colorectal cancers.
    9. Multivariate analysis suggested that MUC15 overexpression was an independent factor for prognosis (hazard risk: 3.216; P=0.009). It was concluded that MUC15 is overexpressed in glioma tissues.
      Title: Correlations of MUC15 overexpression with clinicopathological features and prognosis of glioma.
    10. MUC15 inhibits dimerization of EGFR and PI3K-AKT signaling and is associated with aggressive hepatocellular carcinomas in patients.
      Title: MUC15 inhibits dimerization of EGFR and PI3K-AKT signaling and is associated with aggressive hepatocellular carcinomas in patients.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common body mass index-associated variants confer risk of extreme obesity.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    mucin-15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135091.2 → NP_001128563.1  mucin-15 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC036114, AY358668, BU676338, DA842986
      Consensus CDS
      CCDS44557.1
      UniProtKB/TrEMBL
      A0A0A0MT67
      Related
      ENSP00000431983.1, ENST00000529533.6
      Conserved Domains (1) summary
      pfam15672
      Location:47 → 361
      Mucin15; Cell-membrane associated Mucin15

    2. NM_001135092.2 → NP_001128564.1  mucin-15 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (c) is shorter than isoform a.
      Source sequence(s)
      AC036114, AJ507429, AY358668, BU676338, DA842986
      Consensus CDS
      CCDS44556.1
      UniProtKB/TrEMBL
      A0A0A0MTD6, A0A3B3IU37
      Related
      ENSP00000431945.1, ENST00000527569.1
      Conserved Domains (1) summary
      pfam15672
      Location:47 → 311
      Mucin15; Cell-membrane associated Mucin15

    3. NM_145650.4 → NP_663625.2  mucin-15 isoform b precursor

      See identical proteins and their annotated locations for NP_663625.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream translation initiation codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AC036114, AK128337, AY358668, BU676338, DA842986
      Consensus CDS
      CCDS7859.1
      UniProtKB/Swiss-Prot
      B3KY00, E9PII6, F8W945, Q6UWS3, Q8IXI8, Q8N387, Q8WW41
      Related
      ENSP00000397339.2, ENST00000455601.6
      Conserved Domains (1) summary
      pfam15672
      Location:20 → 334
      Mucin15; Cell-membrane associated Mucin15

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      26559032..26572263 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      26699699..26712907 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N387.2 GenPept UniProtKB/Swiss-Prot:Q8N387

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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