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    ARL17B ARF like GTPase 17B [ Homo sapiens (human) ]

    Gene ID: 100506084, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ARL17Bprovided by HGNC
    Official Full Name
    ARF like GTPase 17Bprovided by HGNC
    Primary source
    HGNC:HGNC:32387
    See related
    Ensembl:ENSG00000228696 AllianceGenome:HGNC:32387
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARL17; ARL17A
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Predicted to be located in Golgi apparatus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 3.7), testis (RPKM 3.6) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ARL17B in Genome Data Viewer
    Location:
    17q21.31
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (46274184..46361787, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (47136194..47223769, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (44351550..44439153, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:44337043-44337589 Neighboring gene chromosome 17 open reading frame 58 pseudogene Neighboring gene uncharacterized LOC124904014 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:44361168-44362367 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:44365530-44366030 Neighboring gene leucine rich repeat containing 37A Neighboring gene DND microRNA-mediated repression inhibitor 1 pseudogene 2 Neighboring gene RNA, 7SL, cytoplasmic 656, pseudogene Neighboring gene Sharpr-MPRA regulatory region 7330 Neighboring gene leucine rich repeat containing 37 member A2 Neighboring gene N-ethylmaleimide-sensitive factor pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:44569061-44569562 Neighboring gene ARF like GTPase 17A Neighboring gene RDM1 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Lysine acetylation targets protein complexes and co-regulates major cellular functions. Choudhary C, et al. Science, 2009 Aug 14. PMID 19608861
    2. The sequence of the human genome. Venter JC, et al. Science, 2001 Feb 16. PMID 11181995
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ76374, FLJ79506, MGC45095

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribosylation factor-like protein 17
    Names
    ADP ribosylation factor like GTPase 17B
    ADP-ribosylation factor 7
    ADP-ribosylation factor-like 17B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039083.5 → NP_001034172.3  ADP-ribosylation factor-like protein 17 isoform a

      See identical proteins and their annotated locations for NP_001034172.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC217777
      Consensus CDS
      CCDS58557.1
      UniProtKB/Swiss-Prot
      B0AZR6, Q59FW5, Q8IVW1, Q8N6E2, Q8TD73, Q8WW54, Q9NZD5, Q9P158
      UniProtKB/TrEMBL
      A0A0G2JMH3, A8K0M5
      Related
      ENSP00000404247.4, ENST00000450673.4
      Conserved Domains (3) summary
      COG1100
      Location:13 → 88
      Gem1; GTPase SAR1 family domain [General function prediction only]
      pfam15840
      Location:115 → 176
      ARL17; ADP-ribosylation factor-like protein 17
      cl21455
      Location:1 → 87
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001103154.2 → NP_001096624.1  ADP-ribosylation factor-like protein 17 isoform b

      See identical proteins and their annotated locations for NP_001096624.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate exon in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct and shorter C-terminus, compared to isoform a. Variants 2 and 4 encode the same isoform (b).
      Source sequence(s)
      AC005829, AC217777, AI638797
      Consensus CDS
      CCDS54137.1
      UniProtKB/Swiss-Prot
      Q8IVW1
      Related
      ENSP00000459151.1, ENST00000570618.6
      Conserved Domains (1) summary
      cl21455
      Location:1 → 88
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_001330240.1 → NP_001317169.1  ADP-ribosylation factor-like protein 17 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate exon in the 3' coding region, compared to variant 1. The encoded isoform (c) has a distinct and shorter C-terminus, compared to isoform a.
      Source sequence(s)
      AC217777, CA420101
      UniProtKB/TrEMBL
      I3L1V5, I3L2E4
      Conserved Domains (2) summary
      COG1100
      Location:13 → 85
      Gem1; GTPase SAR1 family domain [General function prediction only]
      cl21455
      Location:1 → 86
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. NM_001352769.1 → NP_001339698.1  ADP-ribosylation factor-like protein 17 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate exon in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct and shorter C-terminus, compared to isoform a. Variants 2 and 4 encode the same isoform (b).
      Source sequence(s)
      AC005829, AC217777
      Consensus CDS
      CCDS54137.1
      Related
      ENSP00000499587.1, ENST00000656849.1
      Conserved Domains (1) summary
      cl21455
      Location:1 → 88
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    5. NM_001363805.1 → NP_001350734.1  ADP-ribosylation factor-like protein 17 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC217777
      UniProtKB/TrEMBL
      A0A994J5X1, I3L3L1
      Related
      ENSP00000458681.2, ENST00000572991.6
      Conserved Domains (2) summary
      pfam15840
      Location:115 → 176
      ARL17; ADP-ribosylation factor-like protein 17
      cl21455
      Location:1 → 87
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      46274184..46361787 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      47136194..47223769 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IVW1.2 GenPept UniProtKB/Swiss-Prot:Q8IVW1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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