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Bmp4 bone morphogenetic protein 4 [ Mus musculus (house mouse) ]

Gene ID: 12159, updated on 18-Nov-2024

Summary

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Official Symbol: Bmp4provided by MGI
Official Full Name: bone morphogenetic protein 4provided by MGI
Primary source: MGI:MGI:88180
See related: Ensembl:ENSMUSG00000021835 AllianceGenome:MGI:88180
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bmp-4; Bmp2b; Bmp2b1; Bmp2b-1
Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Homozygous knockout mice die in utero, while a conditional knockout mouse exhibits defects in heart development. Transgenic mice overexpressing this gene in a neuron-specific manner exhibit a phenotype resembling the rare hereditary connective tissue disease, fibrodysplasia ossificans progressiva. [provided by RefSeq, Jul 2016]
Expression: Broad expression in bladder adult (RPKM 26.3), lung adult (RPKM 20.8) and 18 other tissues See more
Orthologs: human all
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Genomic context

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See Bmp4 in Genome Data Viewer

Location:: 14 C1; 14 23.95 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (46620982..46628126, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (46383525..46390669, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Temporal BMP4 effects on mouse embryonic and extraembryonic development.
Title: Temporal BMP4 effects on mouse embryonic and extraembryonic development.
Overexpression of Bmp4 induces microphthalmia by disrupting embryonic neural retina.
Title: Overexpression of Bmp4 induces microphthalmia by disrupting embryonic neural retina.
Bone morphogenic protein-4 availability in the cardiac microenvironment controls inflammation and fibrosis in autoimmune myocarditis.
Title: Bone morphogenic protein-4 availability in the cardiac microenvironment controls inflammation and fibrosis in autoimmune myocarditis.
Divergent and Compensatory Effects of BMP2 and BMP4 on the VSMC Phenotype and BMP4's Role in Thoracic Aortic Aneurysm Development.
Title: Divergent and Compensatory Effects of BMP2 and BMP4 on the VSMC Phenotype and BMP4's Role in Thoracic Aortic Aneurysm Development.
BMP4 up-regulated by 630 nm LED irradiation is associated with the amelioration of rheumatoid arthritis.
Title: BMP4 up-regulated by 630 nm LED irradiation is associated with the amelioration of rheumatoid arthritis.
Influence of FGF4 and BMP4 on FGFR2 dynamics during the segregation of epiblast and primitive endoderm cells in the pre-implantation mouse embryo.
Title: Influence of FGF4 and BMP4 on FGFR2 dynamics during the segregation of epiblast and primitive endoderm cells in the pre-implantation mouse embryo.
Blood endothelial ALK1-BMP4 signaling axis regulates adult hair follicle stem cell activation.
Title: Blood endothelial ALK1-BMP4 signaling axis regulates adult hair follicle stem cell activation.
Cuspal Shape Alterations by Bmp4 Directing Cell Proliferation and Apoptosis.
Title: Cuspal Shape Alterations by Bmp4 Directing Cell Proliferation and Apoptosis.
Disruption of BMP4 signaling is associated with laryngeal birth defects in a mouse model.
Title: Disruption of BMP4 signaling is associated with laryngeal birth defects in a mouse model.
BMP4 triggers regulatory circuits specifying the cardiac mesoderm lineage.
Title: BMP4 triggers regulatory circuits specifying the cardiac mesoderm lineage.

Submit: New GeneRIF Correction See all GeneRIFs (335)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (20) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:496641 (e-PCR)
- UniSTS:496641

Bmp4 (e-PCR), detects polymorphism
- UniSTS:496641

D14Mit129 (e-PCR), detects polymorphism
- UniSTS:127234

RH94860 (e-PCR)
- UniSTS:120106

BMP4_296 (e-PCR)
- UniSTS:277036

PMC156609P1 (e-PCR)
- UniSTS:271413

Bmp4 (e-PCR), detects polymorphism
- UniSTS:532293

PMC316400P2 (e-PCR)
- UniSTS:272980

PMC316400P3 (e-PCR)
- UniSTS:272981

Bmp4 (e-PCR), detects polymorphism
- UniSTS:141181

UniSTS:497280 (e-PCR)
- UniSTS:497280

Bmp4 (e-PCR), detects polymorphism
- UniSTS:497280

Bmp4 (e-PCR), detects polymorphism
- UniSTS:506753

Bmp4 (e-PCR), detects polymorphism
- UniSTS:532664

Bmp4 (e-PCR), detects polymorphism
- UniSTS:265413

Bmp4 (e-PCR), detects polymorphism
- UniSTS:207058

Bmp4 (e-PCR), detects polymorphism
- UniSTS:478950

Bmp4 (e-PCR), detects polymorphism
- UniSTS:526068

MARC_5761-5762:996690803:2 (e-PCR)
- UniSTS:269563

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables BMP receptor binding	ISO Inferred from Sequence Orthology more info	PubMed
enables BMP receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables chemoattractant activity	ISO Inferred from Sequence Orthology more info
enables chemoattractant activity	ISS Inferred from Sequence or Structural Similarity more info
enables co-receptor binding	IEA Inferred from Electronic Annotation more info
enables co-receptor binding	ISO Inferred from Sequence Orthology more info
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within BMP signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in BMP signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of ameloblast differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within anatomical structure development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within anatomical structure formation involved in morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within anterior/posterior axis specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in aortic valve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in apoptotic process involved in endocardial cushion morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel development	IDA Inferred from Direct Assay more info	PubMed
involved_in blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within bone development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within branching involved in prostate gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in branching involved in ureteric bud morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within bronchus development	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within bud dilation involved in lung branching	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within bud elongation involved in lung branching	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within camera-type eye development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within camera-type eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in cardiac jelly development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac muscle cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cardiac muscle cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in cardiac muscle hypertrophy in response to stress	ISO Inferred from Sequence Orthology more info
NOT involved_in cardiac right ventricle morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell fate commitment	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to BMP stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to dexamethasone stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of chondrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in chondrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in coronary vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cranial suture morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in deltoid tuberosity development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal/ventral neural tube patterning	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic digit morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic hindlimb morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic limb morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic limb morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic skeletal joint morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic skeletal joint morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic skeletal system morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocardial cushion development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endochondral ossification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endoderm development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of epithelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within epithelial cell proliferation involved in lung morphogenesis	ISO Inferred from Sequence Orthology more info	PubMed
NOT involved_in epithelial to mesenchymal transition involved in endocardial cushion formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within epithelial-mesenchymal cell signaling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within epithelium development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within erythrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in eye development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within forebrain development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within forebrain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glomerular capillary formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart induction	ISO Inferred from Sequence Orthology more info
involved_in heart induction	ISS Inferred from Sequence or Structural Similarity more info
involved_in heart morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in hematopoietic progenitor cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within inner ear auditory receptor cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intermediate mesodermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in intermediate mesodermal cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in kidney development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in kidney development	ISO Inferred from Sequence Orthology more info
involved_in kidney development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within lens induction in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung alveolus development	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within lung development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung morphogenesis	ISO Inferred from Sequence Orthology more info	PubMed
involved_in lung vasculature development	ISO Inferred from Sequence Orthology more info
involved_in lung vasculature development	ISS Inferred from Sequence or Structural Similarity more info
involved_in lymphoid progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in lymphoid progenitor cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in macrophage differentiation	IEA Inferred from Electronic Annotation more info
involved_in macrophage differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mammary gland formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membranous septum morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesoderm formation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within mesodermal cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within mesodermal cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesonephros development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within metanephros development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within metanephros development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in monocyte differentiation	ISO Inferred from Sequence Orthology more info
NOT involved_in muscular septum morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell differentiation in thymus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of branching involved in ureteric bud morphogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of branching involved in ureteric bud morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of chondrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glomerular mesangial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glomerular mesangial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of glomerulus development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glomerulus development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of immature T cell proliferation in thymus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of immature T cell proliferation in thymus	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mesenchymal cell proliferation involved in ureter development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mesenchymal cell proliferation involved in ureter development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of metanephric S-shaped body morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of metanephric S-shaped body morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of metanephric comma-shaped body morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of metanephric comma-shaped body morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of miRNA transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitotic nuclear division	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of myoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of prostatic bud formation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of prostatic bud formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of striated muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of thymocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of thymocyte apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info	PubMed
involved_in nephric duct formation	ISO Inferred from Sequence Orthology more info
involved_in nephric duct formation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neural tube closure	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuron fate commitment	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuron fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in odontogenesis	ISO Inferred from Sequence Orthology more info
involved_in odontogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within organ induction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within osteoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in outflow tract morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in outflow tract septum morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovarian follicle development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pericyte cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in pharyngeal arch artery morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pituitary gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of SMAD protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within positive regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone mineralization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of branching involved in lung morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion transport into cytosol	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle fiber development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle fiber development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of cartilage development	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of collagen biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of endothelial cell migration	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of endothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of epidermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epidermal cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of epithelial cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of epithelial to mesenchymal transition	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hepatocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mesenchymal stem cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of miRNA transcription	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of odontoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of ossification	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of ossification	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of ossification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of p38MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of primary miRNA processing	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of primary miRNA processing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of programmed cell death	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within positive regulation of protein binding	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_positive_effect positive regulation of protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of programmed cell death	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within prostate gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of prostatic bud formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pulmonary valve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of branching involved in prostate gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cartilage development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell fate commitment	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell fate commitment	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of endothelial cell proliferation	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of mesodermal cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of mesodermal cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of morphogenesis of a branching structure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of odontogenesis of dentin-containing tooth	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of smooth muscle cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of smooth muscle cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of smooth muscle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within renal system process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in secondary heart field specification	ISO Inferred from Sequence Orthology more info
involved_in secondary heart field specification	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within skeletal system development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within smooth muscle cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in smooth muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within specification of animal organ position	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in specification of segmental identity, mandibular segment	IDA Inferred from Direct Assay more info	PubMed
involved_in stem cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within telencephalon development	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within telencephalon regionalization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within telencephalon regionalization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in tendon cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within trachea development	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within trachea formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in type B pancreatic cell development	ISO Inferred from Sequence Orthology more info
involved_in type B pancreatic cell development	ISS Inferred from Sequence or Structural Similarity more info
involved_in ureter morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ureteric bud development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within ureteric bud development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ureteric bud development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: bone morphogenetic protein 4

Names: bone morphogenetic protein 2B

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001316360.1 → NP_001303289.1 bone morphogenetic protein 4 preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK136527, AK145359, CT009556

Consensus CDS

CCDS36897.1

UniProtKB/Swiss-Prot

P21275

UniProtKB/TrEMBL

Q3ULR1

Related

ENSMUSP00000098242.3, ENSMUST00000100676.3

Conserved Domains (2) summary

smart00204
Location:308 → 408

TGFB; Transforming growth factor-beta (TGF-beta) family

pfam00688
Location:41 → 276

TGFb_propeptide; TGF-beta propeptide
NM_007554.3 → NP_031580.2 bone morphogenetic protein 4 preproprotein

See identical proteins and their annotated locations for NP_031580.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK136527, AK145359, CT009556

Consensus CDS

CCDS36897.1

UniProtKB/Swiss-Prot

P21275

UniProtKB/TrEMBL

Q3ULR1

Related

ENSMUSP00000073720.6, ENSMUST00000074077.12

Conserved Domains (2) summary

smart00204
Location:308 → 408

TGFB; Transforming growth factor-beta (TGF-beta) family

pfam00688
Location:41 → 276

TGFb_propeptide; TGF-beta propeptide