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    GGTA1 glycoprotein alpha-galactosyltransferase 1 (inactive) [ Bos taurus (domestic cattle) ]

    Gene ID: 281780, updated on 10-Oct-2024

    Summary

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    Gene symbol
    GGTA1
    Gene description
    glycoprotein alpha-galactosyltransferase 1 (inactive)
    See related
    BGD:BT21137; Ensembl:ENSBTAG00000012090
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See GGTA1 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (92316193..92394954, complement)

    Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene N-acetyllactosaminide alpha-1,3-galactosyltransferase-like 1 Neighboring gene glycoprotein galactosyltransferase alpha 1, 3-like Neighboring gene uncharacterized LOC132346630 Neighboring gene DAB2 interacting protein Neighboring gene uncharacterized LOC112448832

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Substrate-assisted and nucleophilically assisted catalysis in bovine α1,3-galactosyltransferase. Mechanistic implications for retaining glycosyltransferases. Gómez H, et al. J Am Chem Soc, 2013 May 8. PMID 23578032
    2. Structural basis of ordered binding of donor and acceptor substrates to the retaining glycosyltransferase, alpha-1,3-galactosyltransferase. Boix E, et al. J Biol Chem, 2002 Aug 2. PMID 12011052
    3. Structure of UDP complex of UDP-galactose:beta-galactoside-alpha -1,3-galactosyltransferase at 1.53-A resolution reveals a conformational change in the catalytically important C terminus. Boix E, et al. J Biol Chem, 2001 Dec 21. PMID 11592969
    4. Bovine alpha 1----3-galactosyltransferase: isolation and characterization of a cDNA clone. Identification of homologous sequences in human genomic DNA. Joziasse DH, et al. J Biol Chem, 1989 Aug 25. PMID 2503516
    5. Bovine alpha1,3-galactosyltransferase catalytic domain structure and its relationship with ABO histo-blood group and glycosphingolipid glycosyltransferases. Gastinel LN, et al. EMBO J, 2001 Feb 15. PMID 11179209, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables hexosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lipid glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in vesicle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    N-acetyllactosaminide alpha-1,3-galactosyltransferase
    Names
    UDP-galactose:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide alpha-1,3-galactosyltransferase
    alpha-galactosyltransferase 1 (glycoprotein)
    alpha1,3-galactosyltransferase
    galactosyltransferase
    NP_803477.1
    XP_005212979.2
    XP_005212980.1
    XP_005212981.1
    XP_010808472.2
    XP_010808474.1
    XP_015329017.1
    XP_024854041.1
    XP_024854045.1
    XP_024854049.1
    XP_059746986.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177511.2 → NP_803477.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase

      See identical proteins and their annotated locations for NP_803477.1

      Status: PROVISIONAL

      Source sequence(s)
      J04989
      UniProtKB/Swiss-Prot
      P14769
      UniProtKB/TrEMBL
      A0AAA9T516
      Related
      ENSBTAP00000016033.2, ENSBTAT00000016033.3
      Conserved Domains (1) summary
      pfam03414
      Location:85 → 366
      Glyco_transf_6; Glycosyltransferase family 6

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      92316193..92394954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024998281.2 → XP_024854049.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X7

      UniProtKB/TrEMBL
      A0AAA9T516
      Conserved Domains (1) summary
      cl11394
      Location:96 → 320
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    2. XM_005212923.5 → XP_005212980.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X3

      See identical proteins and their annotated locations for XP_005212980.1

      UniProtKB/Swiss-Prot
      P14769
      UniProtKB/TrEMBL
      A0AAA9T516
      Conserved Domains (1) summary
      pfam03414
      Location:85 → 366
      Glyco_transf_6; Glycosyltransferase family 6

    3. XM_010810170.4 → XP_010808472.2  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X4

      UniProtKB/TrEMBL
      A0AAF7AT15
      Related
      ENSBTAP00000074297.2, ENSBTAT00000084155.2

    4. XM_005212922.5 → XP_005212979.2  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X3

      UniProtKB/Swiss-Prot
      P14769

    5. XM_024998277.2 → XP_024854045.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X3

      UniProtKB/Swiss-Prot
      P14769
      UniProtKB/TrEMBL
      A0AAA9T516
      Conserved Domains (1) summary
      pfam03414
      Location:85 → 366
      Glyco_transf_6; Glycosyltransferase family 6

    6. XM_024998273.2 → XP_024854041.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X1

      Conserved Domains (1) summary
      cl11394
      Location:293 → 517
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    7. XM_059891003.1 → XP_059746986.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X2

    8. XM_005212924.5 → XP_005212981.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X3

      See identical proteins and their annotated locations for XP_005212981.1

      UniProtKB/Swiss-Prot
      P14769
      UniProtKB/TrEMBL
      A0AAA9T516
      Conserved Domains (1) summary
      pfam03414
      Location:85 → 366
      Glyco_transf_6; Glycosyltransferase family 6

    9. XM_015473531.3 → XP_015329017.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X5

      UniProtKB/TrEMBL
      A0AAA9S3W0, A0AAA9T516
      Related
      ENSBTAP00000078478.1, ENSBTAT00000124589.1
      Conserved Domains (1) summary
      pfam03414
      Location:134 → 417
      Glyco_transf_6; Glycosyltransferase family 6

    10. XM_010810172.4 → XP_010808474.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X6

      UniProtKB/TrEMBL
      A0AAA9T516
      Conserved Domains (1) summary
      pfam03414
      Location:127 → 410
      Glyco_transf_6; Glycosyltransferase family 6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14769.1 GenPept UniProtKB/Swiss-Prot:P14769

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