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    TXNRD1 thioredoxin reductase 1 [ Pongo abelii (Sumatran orangutan) ]

    Gene ID: 100174180, updated on 11-Apr-2024

    Summary

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    Gene symbol
    TXNRD1
    Gene description
    thioredoxin reductase 1
    Locus tag
    CR201_G0001249
    See related
    Ensembl:ENSPPYG00000004893
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Pongo abelii
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
    Orthologs
    human mouse all
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    Genomic context

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    See TXNRD1 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPonAbe1-v2.0_pri (GCF_028885655.2) 10 NC_071995.2 (102924835..102985887)
    RS_2023_04 previous assembly NHGRI_mPonAbe1-v1.1-hic.freeze_pri (GCF_028885655.1) 12 NC_071997.1 (102888770..102949822)

    Chromosome 10 - NC_071995.2Genomic Context describing neighboring genes Neighboring gene thioredoxin reductase 1, cytoplasmic-like Neighboring gene large ribosomal subunit protein uL6-like Neighboring gene large ribosomal subunit protein eL28-like Neighboring gene EP300 interacting inhibitor of differentiation 3 Neighboring gene uncharacterized LOC134759532 Neighboring gene carbohydrate sulfotransferase 11 Neighboring gene ATP synthase F(0) complex subunit C1, mitochondrial-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp459H0128, DKFZp469H1414

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables glutathione-disulfide reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables thioredoxin-disulfide reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in glutathione metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    thioredoxin reductase 1, cytoplasmic
    Names
    TR
    peroxidase TXNRD1
    thioredoxin reductase TR1
    NP_001127133.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001133661.1 → NP_001127133.1  thioredoxin reductase 1, cytoplasmic

      See identical proteins and their annotated locations for NP_001127133.1

      Status: VALIDATED

      Source sequence(s)
      CR926483
      UniProtKB/Swiss-Prot
      Q5NVA2, Q5R5P1
      Related
      ENSPPYP00000005584.3, ENSPPYT00000005798.3
      Conserved Domains (3) summary
      TIGR01438
      Location:11 → 499
      TGR; thioredoxin and glutathione reductase selenoprotein
      pfam00070
      Location:192 → 268
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam02852
      Location:371 → 481
      Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain

    RefSeqs of Annotated Genomes: GCF_028885655.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

    Genomic

    1. NC_071995.2 Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

      Range
      102924835..102985887
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5NVA2.3 GenPept UniProtKB/Swiss-Prot:Q5NVA2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials