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    Epyc epiphycan [ Mus musculus (house mouse) ]

    Gene ID: 13516, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Epycprovided by MGI
    Official Full Name
    epiphycanprovided by MGI
    Primary source
    MGI:MGI:107942
    See related
    Ensembl:ENSMUSG00000019936 AllianceGenome:MGI:107942
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dspg3; PG-Lb; SLRR3B
    Summary
    Acts upstream of or within articular cartilage development; bone development; and sensory perception of sound. Located in extracellular matrix. Is expressed in several structures, including lower jaw; nervous system; notochord; sensory organ; and skeleton. Orthologous to human EPYC (epiphycan). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in limb E14.5 (RPKM 25.0), testis adult (RPKM 5.6) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Epyc in Genome Data Viewer
    Location:
    10 C3; 10 50.35 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (97479930..97517770)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (97644068..97681908)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40749 Neighboring gene keratocan Neighboring gene predicted gene 10754 Neighboring gene RIKEN cDNA 4930525C09 gene Neighboring gene STARR-seq mESC enhancer starr_27692 Neighboring gene coiled-coil glutamate-rich protein 1 Neighboring gene predicted gene, 25658

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The gene structure and organization of mouse PG-Lb, a small chondroitin/dermatan sulphate proteoglycan. Iwata Y, et al. Biochem J, 1998 May 1. PMID 9560328, Free PMC Article
    2. Occurrence of PG-Lb, a leucine-rich small chondroitin/dermatan sulphate proteoglycan in mammalian epiphyseal cartilage: molecular cloning and sequence analysis of the mouse cDNA. Kurita K, et al. Biochem J, 1996 Sep 15. PMID 8836137, Free PMC Article
    3. Epiphycan is specifically expressed in cochlear supporting cells and is necessary for normal hearing. Hanada Y, et al. Biochem Biophys Res Commun, 2017 Oct 21. PMID 28864419
    4. Expression and localization of PG-Lb/epiphycan during mouse development. Johnson J, et al. Dev Dyn, 1999 Dec. PMID 10633869
    5. Decorin, epiphycan, and lumican genes are closely linked on murine Chromosome 10 and are deleted in lethal steel mutants. Danielson KG, et al. Mamm Genome, 1999 Feb. PMID 9922406

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Epyc is necessary for normal auditory function
      Title: Epiphycan is specifically expressed in cochlear supporting cells and is necessary for normal hearing.
    2. Epyc is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
      Title: Tissue expression patterns identify mouse cilia genes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in articular cartilage development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within articular cartilage development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in bone development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within bone development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within bone development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    epiphycan
    Names
    dermatan sulfate proteoglycan 3
    dermatan sulphate proteoglycan 3
    proteoglycan-Lb
    small chondroitin/dermatan sulfate proteoglycan

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379456.1 → NP_001366385.1  epiphycan precursor

      Status: VALIDATED

      Source sequence(s)
      AC099715, AC159710
      UniProtKB/Swiss-Prot
      P70186
      UniProtKB/TrEMBL
      Q3TZF5
      Related
      ENSMUSP00000100922.4, ENSMUST00000105285.4
      Conserved Domains (3) summary
      PRK15370
      Location:126 → 317
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      sd00033
      Location:145 → 168
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:151 → 203
      LRR_8; Leucine rich repeat

    2. NM_007884.2 → NP_031910.1  epiphycan precursor

      See identical proteins and their annotated locations for NP_031910.1

      Status: VALIDATED

      Source sequence(s)
      AK015223
      Consensus CDS
      CCDS24143.1
      UniProtKB/Swiss-Prot
      P70186
      UniProtKB/TrEMBL
      Q3TZF5
      Related
      ENSMUSP00000020094.2, ENSMUST00000020094.8
      Conserved Domains (3) summary
      PRK15370
      Location:126 → 317
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      sd00033
      Location:145 → 168
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:151 → 203
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      97479930..97517770
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70186.1 GenPept UniProtKB/Swiss-Prot:P70186

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
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