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    GPR155 G protein-coupled receptor 155 [ Homo sapiens (human) ]

    Gene ID: 151556, updated on 14-Nov-2024

    Summary

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    Official Symbol
    GPR155provided by HGNC
    Official Full Name
    G protein-coupled receptor 155provided by HGNC
    Primary source
    HGNC:HGNC:22951
    See related
    Ensembl:ENSG00000163328 MIM:620855; AllianceGenome:HGNC:22951
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DEP.7; PGR22; DEPDC3; LYCHOS
    Summary
    Enables cholesterol binding activity. Involved in several processes, including cellular response to amino acid starvation; cellular response to cholesterol; and positive regulation of TORC1 signaling. Located in extracellular exosome. Is active in lysosomal membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in stomach (RPKM 11.2), brain (RPKM 8.6) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GPR155 in Genome Data Viewer
    Location:
    2q31.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (174431571..174487029, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (174920213..174975693, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (175296299..175351757, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene corepressor interacting with RBPJ, CIR1 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:175256788-175256952 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:175260886-175261386 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:175274337-175274938 Neighboring gene secernin 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:175351272-175351454 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12126 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16774 Neighboring gene GPR155 divergent transcript Neighboring gene RPA3 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1. Shin HR, et al. Science, 2022 Sep 16. PMID 36007018, Free PMC Article
    2. Downregulation of GPR155 as a prognostic factor after curative resection of hepatocellular carcinoma. Umeda S, et al. BMC Cancer, 2017 Sep 1. PMID 28863781, Free PMC Article
    3. GPR155 Serves as a Predictive Biomarker for Hematogenous Metastasis in Patients with Gastric Cancer. Shimizu D, et al. Sci Rep, 2017 Feb 6. PMID 28165032, Free PMC Article
    4. Circular RNA hsa_circ_0094976 modulates GPR155 to inhibit gastric adenocarcinoma malignant characteristics by targeting miR-223-3p. Liu L, et al. Pathol Res Pract, 2024 May. PMID 38678850
    5. Genome-wide expression profiling of lymphoblastoid cell lines distinguishes different forms of autism and reveals shared pathways. Nishimura Y, et al. Hum Mol Genet, 2007 Jul 15. PMID 17519220

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Circular RNA hsa_circ_0094976 modulates GPR155 to inhibit gastric adenocarcinoma malignant characteristics by targeting miR-223-3p.
      Title: Circular RNA hsa_circ_0094976 modulates GPR155 to inhibit gastric adenocarcinoma malignant characteristics by targeting miR-223-3p.
    2. Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1.
      Title: Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1.
    3. GPR155 may represent a biomarker for diagnosing and predicting hematogenous metastasis of gastric cancer.
      Title: GPR155 Serves as a Predictive Biomarker for Hematogenous Metastasis in Patients with Gastric Cancer.
    4. Downregulation of GPR155 may serve as a prognosticator that also predicts initial recurrence sites independent of hepatitis virus infection.
      Title: Downregulation of GPR155 as a prognostic factor after curative resection of hepatocellular carcinoma.
    5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ31819, FLJ39346

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cholesterol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to amino acid starvation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to cholesterol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cognition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC1 signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    is_active_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lysosomal cholesterol signaling protein
    Names
    G-protein coupled receptor PGR22
    integral membrane protein GPR155

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033045.4 → NP_001028217.1  lysosomal cholesterol signaling protein isoform 1

      See identical proteins and their annotated locations for NP_001028217.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1, 2 and 3 encode the same isoform.
      Source sequence(s)
      AC018470, AK056381, AL834154
      Consensus CDS
      CCDS2259.1
      UniProtKB/Swiss-Prot
      B2RCI2, D3DPE2, Q4G0Y6, Q53SJ3, Q53TA8, Q69YG8, Q7Z3F1, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6
      Related
      ENSP00000295500.4, ENST00000295500.8
      Conserved Domains (2) summary
      cd04443
      Location:751 → 833
      DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...
      cl22894
      Location:38 → 366
      Mem_trans; Membrane transport protein

    2. NM_001267050.2 → NP_001253979.1  lysosomal cholesterol signaling protein isoform 1

      See identical proteins and their annotated locations for NP_001253979.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC018470, BC035037
      Consensus CDS
      CCDS2259.1
      UniProtKB/Swiss-Prot
      B2RCI2, D3DPE2, Q4G0Y6, Q53SJ3, Q53TA8, Q69YG8, Q7Z3F1, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6
      Related
      ENSP00000376334.2, ENST00000392551.6
      Conserved Domains (2) summary
      cd04443
      Location:751 → 833
      DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...
      cl22894
      Location:38 → 366
      Mem_trans; Membrane transport protein

    3. NM_001267051.2 → NP_001253980.1  lysosomal cholesterol signaling protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC018470, AK056381, BC036681, DC334438
      Consensus CDS
      CCDS74605.1
      UniProtKB/TrEMBL
      A0A087WXK4
      Related
      ENSP00000481104.1, ENST00000614352.4
      Conserved Domains (2) summary
      cd04443
      Location:723 → 805
      DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...
      cl22894
      Location:38 → 366
      Mem_trans; Membrane transport protein

    4. NM_152529.7 → NP_689742.4  lysosomal cholesterol signaling protein isoform 1

      See identical proteins and their annotated locations for NP_689742.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC018470, AK315125
      Consensus CDS
      CCDS2259.1
      UniProtKB/Swiss-Prot
      B2RCI2, D3DPE2, Q4G0Y6, Q53SJ3, Q53TA8, Q69YG8, Q7Z3F1, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6
      Related
      ENSP00000376335.2, ENST00000392552.7
      Conserved Domains (2) summary
      cd04443
      Location:751 → 833
      DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...
      cl22894
      Location:38 → 366
      Mem_trans; Membrane transport protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      174431571..174487029 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017003487.2 → XP_016858976.1  lysosomal cholesterol signaling protein isoform X1

      UniProtKB/Swiss-Prot
      B2RCI2, D3DPE2, Q4G0Y6, Q53SJ3, Q53TA8, Q69YG8, Q7Z3F1, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6
      Conserved Domains (2) summary
      cd04443
      Location:751 → 833
      DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...
      cl22894
      Location:38 → 366
      Mem_trans; Membrane transport protein

    2. XM_017003485.3 → XP_016858974.1  lysosomal cholesterol signaling protein isoform X1

      UniProtKB/Swiss-Prot
      B2RCI2, D3DPE2, Q4G0Y6, Q53SJ3, Q53TA8, Q69YG8, Q7Z3F1, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6
      Conserved Domains (2) summary
      cd04443
      Location:751 → 833
      DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...
      cl22894
      Location:38 → 366
      Mem_trans; Membrane transport protein

    3. XM_047443532.1 → XP_047299488.1  lysosomal cholesterol signaling protein isoform X1

      UniProtKB/Swiss-Prot
      B2RCI2, D3DPE2, Q4G0Y6, Q53SJ3, Q53TA8, Q69YG8, Q7Z3F1, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      174920213..174975693 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340820.1 → XP_054196795.1  lysosomal cholesterol signaling protein isoform X1

      UniProtKB/Swiss-Prot
      B2RCI2, D3DPE2, Q4G0Y6, Q53SJ3, Q53TA8, Q69YG8, Q7Z3F1, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6

    2. XM_054340818.1 → XP_054196793.1  lysosomal cholesterol signaling protein isoform X1

      UniProtKB/Swiss-Prot
      B2RCI2, D3DPE2, Q4G0Y6, Q53SJ3, Q53TA8, Q69YG8, Q7Z3F1, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6

    3. XM_054340819.1 → XP_054196794.1  lysosomal cholesterol signaling protein isoform X1

      UniProtKB/Swiss-Prot
      B2RCI2, D3DPE2, Q4G0Y6, Q53SJ3, Q53TA8, Q69YG8, Q7Z3F1, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z3F1.2 GenPept UniProtKB/Swiss-Prot:Q7Z3F1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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