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    pkhm-2 PH domain-containing protein;RUN domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181612, updated on 2-Nov-2024

    Summary

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    Official Symbol
    pkhm-2
    Official Full Name
    PH domain-containing protein;RUN domain-containing protein
    Primary source
    WormBase:WBGene00011680
    Locus tag
    CELE_T10B10.3
    See related
    AllianceGenome:WB:WBGene00011680
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable kinesin binding activity. Predicted to be involved in Golgi organization; lysosome localization; and regulation of protein localization. Predicted to be located in lysosome. Predicted to be active in endosome membrane. Is expressed in anterior gonad arm. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See pkhm-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    9
    Sequence:
    Chromosome: X; NC_003284.9 (15178096..15181465, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Ion transport domain-containing protein Neighboring gene Peptidase M16 N-terminal domain-containing protein Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A BORC-dependent molecular pathway for vesiculation of cell corpse phagolysosomes. Fazeli G, et al. Curr Biol, 2023 Feb 27. PMID 36652947, Free PMC Article
    2. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables kinesin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lysosome localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    PH domain-containing protein;RUN domain-containing protein
    NP_001408270.1
    • Partially confirmed by transcript evidence
    NP_510523.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      15178096..15181465 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078122.6 → NP_510523.1  RUN domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510523.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22368
      Conserved Domains (2) summary
      smart00233
      Location:515 → 607
      PH; Pleckstrin homology domain
      pfam00169
      Location:515 → 608
      PH; PH domain

    2. NM_001421342.1 → NP_001408270.1  PH domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8S4QCL7
    Nucleotide Protein
    Heading Accession and Version

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