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    Prph peripherin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24688, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Prphprovided by RGD
    Official Full Name
    peripherinprovided by RGD
    Primary source
    RGD:3414
    See related
    EnsemblRapid:ENSRNOG00000052880 AllianceGenome:RGD:3414
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Perf; Prph1
    Summary
    Predicted to enable structural molecule activity. Involved in intermediate filament cytoskeleton organization. Located in neuronal cell body; terminal bouton; and type III intermediate filament. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 1. Orthologous to human PRPH (peripherin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 34.2), Brain (RPKM 24.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prph in Genome Data Viewer
    Location:
    7q36
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (132096888..132101070)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (130218149..130222136)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (140742406..140746197)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene tubulin, alpha 1C Neighboring gene uncharacterized LOC120093830 Neighboring gene uncharacterized LOC102546594 Neighboring gene trophinin associated protein Neighboring gene complement C1q like 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Translation initiation and assembly of peripherin in cultured cells. Ho CL, et al. Eur J Cell Biol, 1995 Oct. PMID 8575457
    2. Structure of the gene encoding peripherin, an NGF-regulated neuronal-specific type III intermediate filament protein. Thompson MA, et al. Neuron, 1989 Jan. PMID 2624740
    3. Peripherin immunoreactivity labels small diameter vestibular 'bouton' afferents in rodents. Lysakowski A, et al. Hear Res, 1999 Jul. PMID 10416873, Free PMC Article
    4. Relationship between the nerve growth factor-regulated clone 73 gene product and the 58-kilodalton neuronal intermediate filament protein (peripherin). Aletta JM, et al. J Neurochem, 1988 Oct. PMID 3418352
    5. A type III intermediate filament gene is expressed in mature neurons. Parysek LM, et al. Neuron, 1988 Jul. PMID 3272173

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study demonistrated that differential expression of peripherin and NF-H after injury occurs in both cutaneous and muscular afferent neurons after injury.
      Title: Peripherin and ATF3 genes are differentially regulated in regenerating and non-regenerating primary sensory neurons.
    2. Using a morphological approach that peripherin expression in subpopulations within the dorsal root ganglia sensory neurons. And peripherin is specifically expressed in unmyelinated fibers.
      Title: Neuronal intermediate filament expression in rat dorsal root ganglia sensory neurons: an in vivo and in vitro study.
    3. By birth, and for 2 or 3 days, peripherin expression was gradually restricted to the type II neuronal population and their projections.
      Title: New insights into peripherin expression in cochlear neurons.
    4. peripherin is a novel substrate for Akt in vivo and its phosphorylation may play a role in motor nerve regeneration
      Title: Identification of peripherin as a Akt substrate in neurons.
    5. Peripherin nitration is not restricted to PC12 cells but it is also present in vivo in rat brain.
      Title: Tyrosine nitration is a novel post-translational modification occurring on the neural intermediate filament protein peripherin.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intermediate filament cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intermediate filament cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in C-fiber ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intermediate filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neurofilament ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in photoreceptor outer segment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in photoreceptor outer segment membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in terminal bouton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in terminal bouton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in type III intermediate filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in type III intermediate filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peripherin
    Names
    peripherin 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012633.3 → NP_036765.3  peripherin

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6KCD5
      Related
      ENSRNOP00000072008.2, ENSRNOT00000089211.3
      Conserved Domains (2) summary
      pfam00038
      Location:99 → 409
      Filament; Intermediate filament protein
      pfam04732
      Location:21 → 98
      Filament_head; Intermediate filament head (DNA binding) region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      132096888..132101070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008765669.4 → XP_008763891.1  peripherin isoform X2

      UniProtKB/TrEMBL
      A0A8I6AT59, Q496Z5
      Conserved Domains (2) summary
      pfam00038
      Location:99 → 441
      Filament; Intermediate filament protein
      pfam04732
      Location:21 → 98
      Filament_head; Intermediate filament head (DNA binding) region

    2. XM_006257321.5 → XP_006257383.1  peripherin isoform X1

      See identical proteins and their annotated locations for XP_006257383.1

      UniProtKB/Swiss-Prot
      P21807
      UniProtKB/TrEMBL
      A6KCD4
      Related
      ENSRNOP00000097710.2, ENSRNOT00000094354.2
      Conserved Domains (2) summary
      pfam00038
      Location:99 → 441
      Filament; Intermediate filament protein
      pfam04732
      Location:21 → 98
      Filament_head; Intermediate filament head (DNA binding) region

    3. XM_063262998.1 → XP_063119068.1  peripherin isoform X3

      UniProtKB/TrEMBL
      F1M7P4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21807.1 GenPept UniProtKB/Swiss-Prot:P21807

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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    Molecular Biology Databases
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