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    NR3C1 nuclear receptor subfamily 3 group C member 1 [ Homo sapiens (human) ]

    Gene ID: 2908, updated on 3-Nov-2024

    Summary

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    Official Symbol
    NR3C1provided by HGNC
    Official Full Name
    nuclear receptor subfamily 3 group C member 1provided by HGNC
    Primary source
    HGNC:HGNC:7978
    See related
    Ensembl:ENSG00000113580 MIM:138040; AllianceGenome:HGNC:7978
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GR; GCR; GRL; GCCR; GCRST
    Summary
    This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
    Expression
    Ubiquitous expression in fat (RPKM 11.8), lung (RPKM 9.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NR3C1 in Genome Data Viewer
    Location:
    5q31.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (143277931..143435512, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (143809293..143966896, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (142657496..142815077, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 26 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142593978-142594526 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142594527-142595075 Neighboring gene uncharacterized LOC124901099 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16479 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23335 Neighboring gene uncharacterized LOC124901100 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23336 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23337 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23338 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23339 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23340 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23341 Neighboring gene ribosomal protein L7 pseudogene 21 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16480 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23342 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16481 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16482 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16483 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:142784152-142784919 Neighboring gene uncharacterized LOC128966704 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:142784920-142785686 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23347 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16484 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23348 Neighboring gene Sharpr-MPRA regulatory region 10277 Neighboring gene uncharacterized LOC105378208 Neighboring gene uncharacterized LOC105378209 Neighboring gene RNA, U7 small nuclear 156 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23349 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:142974806-142976005

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Investigation of glucocorticoid receptor polymorphisms in relation to metabolic parameters in Addison's disease. Ross IL, et al. Eur J Endocrinol, 2013 Mar. PMID 23239757
    2. Further characterization of human glucocorticoid receptor mutants, R477H and G679S, associated with primary generalized glucocorticoid resistance. Ruiz M, et al. Scand J Clin Lab Invest, 2013 Apr. PMID 23391271
    3. The glucocorticoid receptor gene polymorphism N363S predisposes to more severe toxic side effects during pediatric acute lymphoblastic leukemia (ALL) therapy. Eipel OT, et al. Int J Hematol, 2013 Feb. PMID 23355259
    4. Expression of the glucocorticoid receptor in the human adrenal cortex. Paust HJ, et al. Exp Clin Endocrinol Diabetes, 2006 Jan. PMID 16450310
    5. Impaired nuclear translocation of glucocorticoid receptors: novel findings from psoriatic epidermal keratinocytes. Man XY, et al. Cell Mol Life Sci, 2013 Jun. PMID 23334186, Free PMC Article

    See all (1000) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Glucocorticoid Receptor: Isoforms, Functions, and Contribution to Glucocorticoid Sensitivity.
      Title: The Glucocorticoid Receptor: Isoforms, Functions, and Contribution to Glucocorticoid Sensitivity.
    2. The relationship of the methylation status and polymorphism of glucocorticoid receptor gene (NR3C1) with attempted suicide or non-suicidal self-injury patients in schizophrenia.
      Title: The relationship of the methylation status and polymorphism of glucocorticoid receptor gene (NR3C1) with attempted suicide or non-suicidal self-injury patients in schizophrenia.
    3. Maternal perceived stress and green spaces during pregnancy are associated with adult offspring gene (NR3C1 and IGF2/H19) methylation patterns in adulthood: A pilot study.
      Title: Maternal perceived stress and green spaces during pregnancy are associated with adult offspring gene (NR3C1 and IGF2/H19) methylation patterns in adulthood: A pilot study.
    4. Association between NR3C1 gene polymorphisms and age-related hearing impairment in Qingdao Chinese elderly.
      Title: Association between NR3C1 gene polymorphisms and age-related hearing impairment in Qingdao Chinese elderly.
    5. Maternal sensitivity and child internalizing and externalizing behavior: a mediating role for glucocorticoid receptor gene (NR3C1) methylation?
      Title: Maternal sensitivity and child internalizing and externalizing behavior: a mediating role for glucocorticoid receptor gene (NR3C1) methylation?
    6. Differential impact of prenatal PTSD symptoms and preconception trauma exposure on placental NR3C1 and FKBP5 methylation.
      Title: Differential impact of prenatal PTSD symptoms and preconception trauma exposure on placental NR3C1 and FKBP5 methylation.
    7. Methylation of the Glucocorticoid Receptor Gene (NR3C1) in Adolescents with a History of Childhood Adversity Engaging in Non-Suicidal Self-Injury.
      Title: Methylation of the Glucocorticoid Receptor Gene (NR3C1) in Adolescents with a History of Childhood Adversity Engaging in Non-Suicidal Self-Injury.
    8. Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer.
      Title: Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer.
    9. Chromatin accessibility and pioneer factor FOXA1 restrict glucocorticoid receptor action in prostate cancer.
      Title: Chromatin accessibility and pioneer factor FOXA1 restrict glucocorticoid receptor action in prostate cancer.
    10. The glucocorticoid receptor gene (NR3C1) is linked to and associated with polycystic ovarian syndrome in Italian families.
      Title: The glucocorticoid receptor gene (NR3C1) is linked to and associated with polycystic ovarian syndrome in Italian families.
    Submit: New GeneRIF Correction See all GeneRIFs (857)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Glucocorticoid resistance
    MedGen: C1841972 OMIM: 615962 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide meta-analysis identifies new susceptibility loci for migraine.
    EBI GWAS Catalog
    Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr Glucocorticoid receptor (GR) agonists, dexamethasone (Dex) and medroxyprogesterone acetate (MPA), enhance HIV-1 Vpr peptide (amino acids 52-96)-mediated apoptosis of CD4+ T-cells in a GR-dependent manner PubMed
    vpr HIV-1 Vpr leucine residues mediate Vpr-Glucocorticoid Receptor (GR) interaction and promoter transactivation; mutation at residue L22 results in 8- to 11-fold higher GRE and HIV-1 LTR transactivation, while L42 and L67 mutants showed reduced activation PubMed
    vpr HIV-1 Vpr activates transcription of glucocorticoid-responsive promoters by binding directly to p300/CBP co-activators, forming a stable complex with p300 and interacting with ligand-bound glucocorticoid receptor PubMed
    vpr HIV-1 Vpr potentiates the trans-activation, but not the trans-repression, properties of the glucocorticoid receptor on NF-kappa B and activating protein 1-regulated simple promoters PubMed
    vpr HIV-1 Vpr (amino acids 22-26 and 64-68) binds to and activates glucocorticoid receptor (GR) and transactivates the HIV-1 LTR promoter through the host GR pathway PubMed
    vpr HIV-1 Vpr targets the glucocorticoid receptor type II complex through an interaction with Vpr interacting protein 1 (Rip-1), a 41 kDa cytosolic protein that binds to Vpr and in a complex with the human glucocorticoid receptor PubMed
    vpr HIV-1 Vpr affects the gene expression of glucocorticoid-regulated genes (IL-12, CD44, Toll-like receptor 4 and indolamine 2,3-dioxygenase, macrophage receptor with collagenous structure, and thrombospondin 1) through activation of the GR pathway PubMed
    vpr Studies suggest effects of HIV-1 Vpr on cytokine expression (IL-2, IL-10, IL-12, TNFalpha and IL-4) and T-cell proliferation may be mediated through activation of the glucocorticoid receptor pathway PubMed
    vpr Interaction of HIV-1 Vpr and hVIP/mov34 may be involved in the activation of glucocorticoid receptor by Vpr PubMed
    vpr Transcription factors TFIIH, CDK7, Cyclin H, and MAT1 enhance HIV-1 Vpr activation of glucocorticoid receptor PubMed
    vpr HIV-1 Vpr synergistically enhances SRC-1 ligand-activated glucocorticoid receptor activity PubMed
    vpr HIV-1 Vpr (amino acids 1-35) binds to TFIID, an interaction that is associated with the ability of Vpr to stimulate transcription through the glucocorticoid receptor pathway PubMed
    vpr Specific binding of HIV-1 Vpr (amino acids 15-35) to TFIIB (amino acids 52-55) causes a conformational change in TFIIB and is correlated with the ability of Vpr to stimulate transcription through the glucocorticoid receptor pathway PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables Hsp90 protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables TBP-class protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables estrogen response element binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear glucocorticoid receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables steroid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables steroid hormone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adrenal gland development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in astrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to dexamethasone stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to glucocorticoid stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to steroid hormone stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to transforming growth factor beta stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glucocorticoid mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glucocorticoid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mammary gland duct morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maternal behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microglia differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in motor behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuroinflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear receptor-mediated glucocorticoid signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear receptor-mediated steroid hormone signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of miRNA transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of glucocorticoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in synaptic transmission, glutamatergic IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glucocorticoid receptor
    Names
    nuclear receptor subfamily 3 group C member 1 variant hGR-B(54)
    nuclear receptor subfamily 3 group C member 1 variant hGR-B(77)
    nuclear receptor subfamily 3 group C member 1 variant hGR-B(93)
    nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009062.1 RefSeqGene

      Range
      36827..162579
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000176.3 → NP_000167.1  glucocorticoid receptor isoform alpha

      See identical proteins and their annotated locations for NP_000167.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes the predominant physiological isoform (alpha, also known as GRalpha or GR-A). Variants 1-5 encode the same isoform.
      Source sequence(s)
      AC004782, AC091925, X03225
      Consensus CDS
      CCDS4278.1
      UniProtKB/Swiss-Prot
      A0ZXF9, B0LPG8, D3DQF4, F5ATB7, P04150, P04151, Q53EP5, Q6N0A4
      UniProtKB/TrEMBL
      A0A5B9RIM3, F1D8N4
      Related
      ENSP00000377977.2, ENST00000394464.7
      Conserved Domains (3) summary
      cd07076
      Location:531 → 777
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:417 → 494
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:26 → 401
      GCR; Glucocorticoid receptor

    2. NM_001018074.1 → NP_001018084.1  glucocorticoid receptor isoform alpha

      See identical proteins and their annotated locations for NP_001018084.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternative 5' terminal non-coding exon, thus has a different 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (alpha).
      Source sequence(s)
      AC004782, AC091925, X03225
      Consensus CDS
      CCDS4278.1
      UniProtKB/Swiss-Prot
      A0ZXF9, B0LPG8, D3DQF4, F5ATB7, P04150, P04151, Q53EP5, Q6N0A4
      UniProtKB/TrEMBL
      A0A5B9RIM3, F1D8N4
      Conserved Domains (3) summary
      cd07076
      Location:531 → 777
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:417 → 494
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:26 → 401
      GCR; Glucocorticoid receptor

    3. NM_001018075.1 → NP_001018085.1  glucocorticoid receptor isoform alpha

      See identical proteins and their annotated locations for NP_001018085.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternative 5' terminal non-coding exon, thus has a different 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (alpha)
      Source sequence(s)
      AC004782, AC091925, X03225
      Consensus CDS
      CCDS4278.1
      UniProtKB/Swiss-Prot
      A0ZXF9, B0LPG8, D3DQF4, F5ATB7, P04150, P04151, Q53EP5, Q6N0A4
      UniProtKB/TrEMBL
      A0A5B9RIM3, F1D8N4
      Conserved Domains (3) summary
      cd07076
      Location:531 → 777
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:417 → 494
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:26 → 401
      GCR; Glucocorticoid receptor

    4. NM_001018076.2 → NP_001018086.1  glucocorticoid receptor isoform alpha

      See identical proteins and their annotated locations for NP_001018086.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an alternative 5' terminal non-coding exon, thus has a different 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (alpha).
      Source sequence(s)
      AC004782, AC091925, BF966114, X03225
      Consensus CDS
      CCDS4278.1
      UniProtKB/Swiss-Prot
      A0ZXF9, B0LPG8, D3DQF4, F5ATB7, P04150, P04151, Q53EP5, Q6N0A4
      UniProtKB/TrEMBL
      A0A5B9RIM3, F1D8N4
      Related
      ENSP00000427672.1, ENST00000503201.1
      Conserved Domains (3) summary
      cd07076
      Location:531 → 777
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:417 → 494
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:26 → 401
      GCR; Glucocorticoid receptor

    5. NM_001018077.1 → NP_001018087.1  glucocorticoid receptor isoform alpha

      See identical proteins and their annotated locations for NP_001018087.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains an alternative 5' terminal non-coding exon, thus has a different 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (alpha).
      Source sequence(s)
      AC004782, AC091925, X03225
      Consensus CDS
      CCDS4278.1
      UniProtKB/Swiss-Prot
      A0ZXF9, B0LPG8, D3DQF4, F5ATB7, P04150, P04151, Q53EP5, Q6N0A4
      UniProtKB/TrEMBL
      A0A5B9RIM3, F1D8N4
      Related
      ENSP00000343205.2, ENST00000343796.6
      Conserved Domains (3) summary
      cd07076
      Location:531 → 777
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:417 → 494
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:26 → 401
      GCR; Glucocorticoid receptor

    6. NM_001020825.2 → NP_001018661.1  glucocorticoid receptor isoform beta

      See identical proteins and their annotated locations for NP_001018661.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. This results in a frame-shift and a shorter isoform (beta, also known as GRbeta) with a distinct C-terminus compared to isoform alpha. This isoform resides primarily in the nucleus, lacks hormone-binding activity, and has a dominant negative effect on the action of isoform alpha (PMID:8621628).
      Source sequence(s)
      AC004782, AC091925, X03348
      Consensus CDS
      CCDS47298.1
      UniProtKB/TrEMBL
      E5KQF5, H6V745
      Related
      ENSP00000387672.2, ENST00000415690.6
      Conserved Domains (3) summary
      cd07172
      Location:417 → 494
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:26 → 401
      GCR; Glucocorticoid receptor
      cl11397
      Location:531 → 729
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    7. NM_001024094.2 → NP_001019265.1  glucocorticoid receptor isoform gamma

      See identical proteins and their annotated locations for NP_001019265.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) uses an alternate in-frame donor splice site at one of the coding exons compared to variant 1. This results in an isoform (gamma) that is 1 aa longer than isoform alpha. The insertion of an additional amino acid (arginine) in the DNA binding domain has been reported to decrease transcriptional activation by the glucocorticoid receptor (PMID:10566686).
      Source sequence(s)
      AC004782, AC091925, U01351
      Consensus CDS
      CCDS34258.1
      UniProtKB/TrEMBL
      A0A5B9RIM3, E5KQF6
      Related
      ENSP00000231509.3, ENST00000231509.7
      Conserved Domains (3) summary
      cd07076
      Location:532 → 778
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:417 → 495
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:26 → 401
      GCR; Glucocorticoid receptor

    8. NM_001204258.2 → NP_001191187.1  glucocorticoid receptor isoform alpha-B

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-B, also known as GR-B) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 571-573).
      Source sequence(s)
      AC004782, AC091925, CA425706, U01351, X03225
      UniProtKB/TrEMBL
      A0A5B9RIM3
      Conserved Domains (3) summary
      cd07076
      Location:505 → 751
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:391 → 468
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:1 → 375
      GCR; Glucocorticoid receptor

    9. NM_001204259.2 → NP_001191188.1  glucocorticoid receptor isoform alpha-C1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-C1, also known as GR-C1) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 748-750).
      Source sequence(s)
      AC004782, AC091925, CA425706, U01351, X03225
      UniProtKB/TrEMBL
      A0A5B9RIM3
      Conserved Domains (3) summary
      cd07076
      Location:446 → 692
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:332 → 409
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:1 → 316
      GCR; Glucocorticoid receptor

    10. NM_001204260.2 → NP_001191189.1  glucocorticoid receptor isoform alpha-C2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-C2, also known as GR-C2) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 760-762).
      Source sequence(s)
      AC004782, AC091925, CA425706, U01351, X03225
      UniProtKB/TrEMBL
      A0A5B9RIM3
      Conserved Domains (3) summary
      cd07076
      Location:442 → 688
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:328 → 405
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:1 → 312
      GCR; Glucocorticoid receptor

    11. NM_001204261.2 → NP_001191190.1  glucocorticoid receptor isoform alpha-C3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternative in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-C3, also known as GR-C3) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 784-786).
      Source sequence(s)
      AC004782, AC091925, CA425706, U01351, X03225
      UniProtKB/TrEMBL
      A0A5B9RIM3
      Conserved Domains (3) summary
      cd07076
      Location:434 → 680
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:320 → 397
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:1 → 304
      GCR; Glucocorticoid receptor

    12. NM_001204262.2 → NP_001191191.1  glucocorticoid receptor isoform alpha-D1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-D1, also known as GR-D1) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 1438-1440).
      Source sequence(s)
      AC004782, AC091925, CA425706, U01351, X03225
      UniProtKB/TrEMBL
      B7Z7I2
      Conserved Domains (3) summary
      cd07076
      Location:216 → 462
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:102 → 179
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:1 → 86
      GCR; Glucocorticoid receptor

    13. NM_001204263.2 → NP_001191192.1  glucocorticoid receptor isoform alpha-D2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-D2, also known as GR-D2) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 1483-1485).
      Source sequence(s)
      AC004782, AC091925, CA425706, U01351, X03225
      UniProtKB/TrEMBL
      B7Z7I2
      Conserved Domains (3) summary
      cd07076
      Location:201 → 447
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:87 → 164
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:1 → 71
      GCR; Glucocorticoid receptor

    14. NM_001204264.2 → NP_001191193.1  glucocorticoid receptor isoform alpha-D3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-D3, also known as GR-D3) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 1498-1500).
      Source sequence(s)
      AC004782, AC091925, CA425706, U01351, X03225
      UniProtKB/TrEMBL
      B7Z7I2
      Conserved Domains (3) summary
      cd07076
      Location:196 → 442
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:82 → 159
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:1 → 66
      GCR; Glucocorticoid receptor

    15. NM_001204265.2 → NP_001191194.1  glucocorticoid receptor isoform GR-P

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8, also known as GR-P) is missing 2 exons from the 3' end, and has a different 3' end compared to variant 1. This results in an isoform (GR-P) with a shorter and unique C-terminus compared to isoform alpha. The function of the encoded protein is not known, however, this variant is highly expressed in cells that are resistant to glucocorticoids, and may act to modulate glucocorticoid responsiveness (PMIDs:7796394, 11358809).
      Source sequence(s)
      AA737284, AC091925, BF244382, U01351, U25029
      UniProtKB/TrEMBL
      F5ATB8
      Conserved Domains (3) summary
      cd07172
      Location:417 → 494
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:26 → 401
      GCR; Glucocorticoid receptor
      cl11397
      Location:531 → 674
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    16. NM_001364180.2 → NP_001351109.1  glucocorticoid receptor isoform alpha

      Status: REVIEWED

      Source sequence(s)
      AC004782, AC091925
      Consensus CDS
      CCDS4278.1
      UniProtKB/Swiss-Prot
      A0ZXF9, B0LPG8, D3DQF4, F5ATB7, P04150, P04151, Q53EP5, Q6N0A4
      UniProtKB/TrEMBL
      A0A5B9RIM3, F1D8N4
      Conserved Domains (3) summary
      cd07076
      Location:531 → 777
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:417 → 494
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:26 → 401
      GCR; Glucocorticoid receptor

    17. NM_001364181.2 → NP_001351110.1  glucocorticoid receptor isoform alpha

      Status: REVIEWED

      Source sequence(s)
      AC004782, AC091925
      Consensus CDS
      CCDS4278.1
      UniProtKB/Swiss-Prot
      A0ZXF9, B0LPG8, D3DQF4, F5ATB7, P04150, P04151, Q53EP5, Q6N0A4
      UniProtKB/TrEMBL
      A0A5B9RIM3, F1D8N4
      Conserved Domains (3) summary
      cd07076
      Location:531 → 777
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:417 → 494
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:26 → 401
      GCR; Glucocorticoid receptor

    18. NM_001364182.1 → NP_001351111.1  glucocorticoid receptor isoform alpha

      Status: REVIEWED

      Source sequence(s)
      AC004782, AC091925
      Consensus CDS
      CCDS4278.1
      UniProtKB/Swiss-Prot
      A0ZXF9, B0LPG8, D3DQF4, F5ATB7, P04150, P04151, Q53EP5, Q6N0A4
      UniProtKB/TrEMBL
      A0A5B9RIM3, F1D8N4
      Conserved Domains (3) summary
      cd07076
      Location:531 → 777
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:417 → 494
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:26 → 401
      GCR; Glucocorticoid receptor

    19. NM_001364183.2 → NP_001351112.1  glucocorticoid receptor isoform gamma

      Status: REVIEWED

      Source sequence(s)
      AC004782, AC091925, BX648553
      Consensus CDS
      CCDS34258.1
      UniProtKB/TrEMBL
      A0A5B9RIM3, E5KQF6
      Related
      ENSP00000422518.1, ENST00000504572.5

    20. NM_001364184.2 → NP_001351113.1  glucocorticoid receptor isoform gamma

      Status: REVIEWED

      Source sequence(s)
      AC004782, AC091925
      Consensus CDS
      CCDS34258.1
      UniProtKB/TrEMBL
      A0A5B9RIM3, E5KQF6
      Related
      ENSP00000377979.2, ENST00000394466.6

    21. NM_001364185.1 → NP_001351114.1  glucocorticoid receptor isoform gamma

      Status: REVIEWED

      Source sequence(s)
      AC004782, AC091925
      Consensus CDS
      CCDS34258.1
      UniProtKB/TrEMBL
      A0A5B9RIM3, E5KQF6

    RNA

    1. NR_157096.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC004782, AC091925, AK302050

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      143277931..143435512 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      143809293..143966896 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04150.1 GenPept UniProtKB/Swiss-Prot:P04150

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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