pik3r1.S phosphoinositide-3-kinase regulatory subunit 1 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: pik3r1.S
Official Full Name: phosphoinositide-3-kinase regulatory subunit 1 S homeolog
Primary source: Xenbase:XB-GENE-6254212
Locus tag: XELAEV_18010934mg
See related: EnsemblRapid:ENSXLAG00005005618 AllianceGenome:Xenbase:XB-GENE-6254212
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: grb1; pik3r1; pik3r1-a; pik3r1-b; pik3r1.L; p85-alpha
Summary: Predicted to enable insulin receptor substrate binding activity; phosphatidylinositol 3-kinase regulator activity; and signaling receptor binding activity. Predicted to act upstream of or within several processes, including cell surface receptor protein tyrosine kinase signaling pathway; positive regulation of macromolecule biosynthetic process; and positive regulation of protein import into nucleus. Predicted to be located in cytoplasm and nucleus. Predicted to be part of phosphatidylinositol 3-kinase complex, class IA. Human ortholog(s) of this gene implicated in several diseases, including SHORT syndrome; agammaglobulinemia 7; astroblastoma; endometrial cancer (multiple); and immunodeficiency 36. Orthologous to human PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 1S

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	1S	NC_054372.1 (174974717..175026439, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	1S	NC_030725.1 (158973132..159025011, complement)

Chromosome 1S - NC_054372.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that PI 3-kinase is involved in sperm-induced egg activation via production of PIP3 that would act as a positive regulator of the Src signaling pathway in Xenopus fertilization.
Title: Evidence that phosphatidylinositol 3-kinase is involved in sperm-induced tyrosine kinase signaling in Xenopus egg fertilization.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables ErbB-3 class receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables insulin receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables insulin receptor substrate binding	ISS Inferred from Sequence or Structural Similarity more info
enables insulin-like growth factor receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol 3-kinase regulator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within insulin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within insulin-like growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within intracellular glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphatidylinositol phosphate biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of RNA splicing	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of endoplasmic reticulum unfolded protein response	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of protein import into nucleus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein stabilization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to endoplasmic reticulum stress	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of phosphatidylinositol 3-kinase complex	IEA Inferred from Electronic Annotation more info
part_of phosphatidylinositol 3-kinase complex, class IA	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: phosphatidylinositol 3-kinase regulatory subunit alpha

Names: PI3-kinase p85 subunit alpha; PI3-kinase regulatory subunit alpha; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; phosphoinositide-3-kinase regulatory subunit 1 L homeolog; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); ptdIns-3-kinase p85-alpha; ptdIns-3-kinase regulatory subunit alpha; ptdIns-3-kinase regulatory subunit p85-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001090471.1 → NP_001083940.1 phosphatidylinositol 3-kinase regulatory subunit alpha

See identical proteins and their annotated locations for NP_001083940.1

Status: PROVISIONAL

Source sequence(s)

AY062922

UniProtKB/Swiss-Prot

Q8UUU2

UniProtKB/TrEMBL

A0A974I2A5, B7ZRD8

Related

ENSXLAP00005016628.1, ENSXLAT00005016924.1

Conserved Domains (6) summary

cd09930
Location:615 → 718

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:325 → 434

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cd11910
Location:5 → 80

SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases

cd12924
Location:439 → 599

iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha

cd04388
Location:113 → 312

RhoGAP_p85; RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region ...

pfam16454
Location:438 → 596

PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054372.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

174974717..175026439 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041574330.1 → XP_041430264.1 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1

UniProtKB/TrEMBL

A0A8J1LM99, A0A974I2A5, B7ZRD8

Related

ENSXLAP00005016612.1, ENSXLAT00005016908.1

Conserved Domains (4) summary

cd09930
Location:553 → 656

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:263 → 372

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cd12924
Location:377 → 537

iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha

cd04388
Location:51 → 245

RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...
XM_018235022.2 → XP_018090511.1 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

UniProtKB/TrEMBL

A1L2M1, B3DLK8

Related

ENSXLAP00005016588.1, ENSXLAT00005016881.1
XM_018235029.2 → XP_018090518.1 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3

UniProtKB/TrEMBL

A0A8J0TSN4, A1L2M1

Related

ENSXLAP00005016595.1, ENSXLAT00005016890.1