Gna12 G protein subunit alpha 12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gna12provided by RGD
Official Full Name: G protein subunit alpha 12provided by RGD
Primary source: RGD:71018
See related: EnsemblRapid:ENSRNOG00000001235 AllianceGenome:RGD:71018
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hg1m1
Summary: Enables D5 dopamine receptor binding activity. Involved in response to xenobiotic stimulus. Acts upstream of or within G protein-coupled receptor signaling pathway; negative regulation of vascular associated smooth muscle cell migration; and negative regulation of vascular associated smooth muscle cell proliferation. Located in brush border membrane. Orthologous to human GNA12 (G protein subunit alpha 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 377.5), Heart (RPKM 344.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q11

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (18919629..19000185)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (13805580..13886255)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (15890202..15971212)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Suggest that activation of D3R, by decreasing Galpha12-induced renal damage, may exert a protective effect from renal I/R injury.
Title: Stimulation of Dopamine D3 Receptor Attenuates Renal Ischemia-Reperfusion Injury via Increased Linkage With Gα12.
It was concluded that a D3 receptor interaction with Galpha12/Galpha13 that increases sodium excretion may have a role in the regulation of blood pressure.
Title: Role of Gα(12)- and Gα(13)-protein subunit linkage of D(3) dopamine receptors in the natriuretic effect of D(3) dopamine receptor in kidney.
Endothelial nitric oxide synthase inhibits G12/13 and rho-kinase activated by the angiotensin II type-1 receptor: implication in vascular migration.
Title: Endothelial nitric oxide synthase inhibits G12/13 and rho-kinase activated by the angiotensin II type-1 receptor: implication in vascular migration.
thrombin and lysophosphatidic acid receptors couple to both gna12 and gna13 for growth cone collapse
Title: Lysophosphatidic acid and thrombin receptors require both G alpha12 and G alpha13 to regulate axonal morphology in hippocampal neurons.
Suggest that S1P(2) mediates inhibition of Rac and migration through the coordinated action of G(12/13) and G(q) for Rho activation in vascular smooth muscle.
Title: G12/13 and Gq mediate S1P2-induced inhibition of Rac and migration in vascular smooth muscle in a manner dependent on Rho but not Rho kinase.
Spingosine-1-phosphate induces oxygen free radical generation through a Galpha12/13, PLC-beta-mediated mechanism that facilitates VSMC migration.
Title: Sphingosine-1-phosphate-induced oxygen free radical generation in smooth muscle cell migration requires Galpha12/13 protein-mediated phospholipase C activation.
TRPC6 is upregulated by Galpha12/13 and negatively regulates endothelin-1-induced cardiac myofibroblast formation and collagen synthesis through nuclear factor of activated T cells activation
Title: Galpha12/13-mediated up-regulation of TRPC6 negatively regulates endothelin-1-induced cardiac myofibroblast formation and collagen synthesis through nuclear factor of activated T cells activation.
Ang II stimulates the nuclear translocation and activation of NFAT by integrated pathways including the activation of Galpha(12/13), Rac, NADPH oxidase, and JNK and it is essential for ROS production and NFAT transcriptional activation
Title: Galpha12/13-mediated production of reactive oxygen species is critical for angiotensin receptor-induced NFAT activation in cardiac fibroblasts.
Galpha12 has a role in direct regulation of PP2A activity and tau phosphorylation
Title: Galpha12 directly interacts with PP2A: evidence FOR Galpha12-stimulated PP2A phosphatase activity and dephosphorylation of microtubule-associated protein, tau.
Dopamine receptor D5 is linked to Galpha12 in the nephron.
Title: Galpha12- and Galpha13-protein subunit linkage of D5 dopamine receptors in the nephron.

Submit: New GeneRIF Correction

General gene information

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Markers

OMY6173INRA (e-PCR)
- UniSTS:529165

Gna12 (e-PCR), detects polymorphism
- UniSTS:256614

BE097282 (e-PCR)
- UniSTS:244629

RH128312 (e-PCR)
- UniSTS:211620

RH141162 (e-PCR)
- UniSTS:223158

RH144209 (e-PCR)
- UniSTS:233454

RH138328 (e-PCR)
- UniSTS:220415

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D5 dopamine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables D5 dopamine receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables G protein activity	ISO Inferred from Sequence Orthology more info
enables G-protein beta/gamma-subunit complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase 2A binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase regulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled dopamine receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic digit morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of TOR signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of fibroblast migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of fibroblast migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in brush border membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	TAS Traceable Author Statement more info	PubMed
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: guanine nucleotide-binding protein subunit alpha-12

Names: g alpha-12; guanine nucleotide binding protein (G protein) alpha 12; guanine nucleotide binding protein, alpha 12; heterotrimeric guanine nucleotide-binding protein 1m1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.