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    BICDL1 BICD family like cargo adaptor 1 [ Homo sapiens (human) ]

    Gene ID: 92558, updated on 2-Nov-2024

    Summary

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    Official Symbol
    BICDL1provided by HGNC
    Official Full Name
    BICD family like cargo adaptor 1provided by HGNC
    Primary source
    HGNC:HGNC:28095
    See related
    Ensembl:ENSG00000135127 MIM:617002; AllianceGenome:HGNC:28095
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BICDR1; CCDC64; BICDR-1; CCDC64A; H_267D11.1
    Summary
    Predicted to enable dynactin binding activity and small GTPase binding activity. Predicted to be involved in Golgi to secretory granule transport; neuron projection development; and vesicle transport along microtubule. Predicted to be located in centrosome. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in kidney (RPKM 26.8), skin (RPKM 12.5) and 9 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See BICDL1 in Genome Data Viewer
    Location:
    12q24.23
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (119989236..120094495)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (119976368..120081656)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120427040..120532299)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene citron rho-interacting serine/threonine kinase Neighboring gene microRNA 1178 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:120185956-120187155 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120192166-120192349 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120197803-120197989 Neighboring gene NANOG hESC enhancer GRCh37_chr12:120213039-120213640 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120242131-120242682 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:120306702-120307901 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7118 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4931 Neighboring gene uncharacterized LOC112268087 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7119 Neighboring gene ribosomal protein L35a pseudogene 30 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120423527-120423708 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4932 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120426711-120427684 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120427685-120428656 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120431757-120431860 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7120 Neighboring gene small nucleolar RNA U13 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120490668-120490841 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7121 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120528583-120529175 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120530601-120531244 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120531245-120531888 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120540395-120540996 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:120540997-120541598 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120541599-120542200 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120542201-120542802 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:120556125-120556916 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120555445-120555623 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4941 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr12:120554541-120555332 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr12:120553748-120554540 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7124 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120548255-120548774 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120547737-120548254 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:120547217-120547736 Neighboring gene RAB35 antisense RNA 1 Neighboring gene RAB35, member RAS oncogene family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Bicaudal D Family of Motor Adaptors: Linking Dynein Motility to Cargo Binding. Hoogenraad CC, et al. Trends Cell Biol, 2016 May. PMID 26822037
    2. Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis. Schlager MA, et al. EMBO J, 2010 May 19. PMID 20360680, Free PMC Article
    3. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. Need AC, et al. Hum Mol Genet, 2009 Dec 1. PMID 19734545, Free PMC Article
    4. The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle. Warnatz HJ, et al. J Biol Chem, 2011 Jul 1. PMID 21555518, Free PMC Article
    5. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. Katsogiannou M, et al. Mol Cell Proteomics, 2014 Dec. PMID 25277244, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CCDC64 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.
      Title: The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.
    2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ26450

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables dynactin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables small GTPase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to secretory granule transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to secretory granule transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in vesicle transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    BICD family-like cargo adapter 1
    Names
    BICD-related protein 1
    bicaudal D-related protein 1
    coiled-coil domain containing 64
    coiled-coil domain-containing protein 64A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001367886.1 → NP_001354815.1  BICD family-like cargo adapter 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC004812, AC004815
      Consensus CDS
      CCDS91757.1
      UniProtKB/TrEMBL
      H0YHP2
      Related
      ENSP00000447477.2, ENST00000548673.6

    2. NM_207311.2 → NP_997194.2  BICD family-like cargo adapter 1 isoform 1

      See identical proteins and their annotated locations for NP_997194.2

      Status: VALIDATED

      Source sequence(s)
      AC004812, AC004815, AK129960, U88834
      Consensus CDS
      CCDS41845.1
      UniProtKB/Swiss-Prot
      A8MUC8, B4DWL0, B5MDJ0, O95000, Q6ZP65
      Related
      ENSP00000380690.2, ENST00000397558.6
      Conserved Domains (2) summary
      pfam14988
      Location:120 → 296
      DUF4515; Domain of unknown function (DUF4515)
      cl19252
      Location:167 → 295
      MreC; rod shape-determining protein MreC

    RNA

    1. NR_147892.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC004812, AC004815

    2. NR_147893.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC004812, AC004815

    3. NR_147894.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC004812, AC004815

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      119989236..120094495
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006719694.4 → XP_006719757.1  BICD family-like cargo adapter 1 isoform X1

      Conserved Domains (2) summary
      pfam14988
      Location:120 → 300
      DUF4515; Domain of unknown function (DUF4515)
      cl23720
      Location:164 → 279
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    2. XM_006719696.4 → XP_006719759.1  BICD family-like cargo adapter 1 isoform X5

      Conserved Domains (2) summary
      pfam14988
      Location:120 → 300
      DUF4515; Domain of unknown function (DUF4515)
      cl23720
      Location:164 → 279
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    3. XM_006719697.4 → XP_006719760.1  BICD family-like cargo adapter 1 isoform X7

      Conserved Domains (2) summary
      pfam01665
      Location:99 → 264
      Rota_NSP3; Rotavirus non-structural protein NSP3
      pfam14988
      Location:120 → 300
      DUF4515; Domain of unknown function (DUF4515)

    4. XM_047429890.1 → XP_047285846.1  BICD family-like cargo adapter 1 isoform X8

    5. XM_047429887.1 → XP_047285843.1  BICD family-like cargo adapter 1 isoform X3

    6. XM_011538999.3 → XP_011537301.1  BICD family-like cargo adapter 1 isoform X2

      Conserved Domains (2) summary
      pfam14988
      Location:120 → 300
      DUF4515; Domain of unknown function (DUF4515)
      cl23720
      Location:164 → 279
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    7. XM_047429889.1 → XP_047285845.1  BICD family-like cargo adapter 1 isoform X6

    8. XM_047429888.1 → XP_047285844.1  BICD family-like cargo adapter 1 isoform X4

    9. XM_011539000.2 → XP_011537302.1  BICD family-like cargo adapter 1 isoform X9

      See identical proteins and their annotated locations for XP_011537302.1

      Conserved Domains (1) summary
      TIGR02168
      Location:54 → 379
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    10. XM_047429891.1 → XP_047285847.1  BICD family-like cargo adapter 1 isoform X10

    RNA

    1. XR_007063143.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      119976368..120081656
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373843.1 → XP_054229818.1  BICD family-like cargo adapter 1 isoform X1

    2. XM_054373847.1 → XP_054229822.1  BICD family-like cargo adapter 1 isoform X5

    3. XM_054373849.1 → XP_054229824.1  BICD family-like cargo adapter 1 isoform X7

    4. XM_054373850.1 → XP_054229825.1  BICD family-like cargo adapter 1 isoform X8

    5. XM_054373845.1 → XP_054229820.1  BICD family-like cargo adapter 1 isoform X3

    6. XM_054373844.1 → XP_054229819.1  BICD family-like cargo adapter 1 isoform X2

    7. XM_054373848.1 → XP_054229823.1  BICD family-like cargo adapter 1 isoform X6

    8. XM_054373846.1 → XP_054229821.1  BICD family-like cargo adapter 1 isoform X4

    9. XM_054373851.1 → XP_054229826.1  BICD family-like cargo adapter 1 isoform X9

    10. XM_054373852.1 → XP_054229827.1  BICD family-like cargo adapter 1 isoform X10

    RNA

    1. XR_008488711.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZP65.2 GenPept UniProtKB/Swiss-Prot:Q6ZP65

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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