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    ADA adenosine deaminase [ Homo sapiens (human) ]

    Gene ID: 100, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Optimized expression and purification of a human adenosine deaminase in E. coli and characterization of its Asp8Asn variant.

    Optimized expression and purification of a human adenosine deaminase in E. coli and characterization of its Asp8Asn variant.
    Jennings MR, Min S, Xu GS, Homayuni K, Suresh B, Haikal YA, Blazeck J.,

    12/15/2023
    The Activity of Adenosine Deaminase and Dipeptidyl Peptidase IV in Children With Attention Deficit Hyperactivity Disorder.

    The Activity of Adenosine Deaminase and Dipeptidyl Peptidase IV in Children With Attention Deficit Hyperactivity Disorder.
    Naralan YS, Doğan Ö, Elgün S, Öztop DB, Kılıç BG.

    11/30/2023
    Changes in Adenosine Deaminase Activity and Endothelial Dysfunction after Mild Coronavirus Disease-2019.

    Changes in Adenosine Deaminase Activity and Endothelial Dysfunction after Mild Coronavirus Disease-2019.
    Jedrzejewska A, Kawecka A, Braczko A, Romanowska-Kocejko M, Stawarska K, Deptuła M, Zawrzykraj M, Franczak M, Krol O, Harasim G, Walczak I, Pikuła M, Hellmann M, Kutryb-Zając B., Free PMC Article

    09/14/2023
    Delayed-onset adenosine deaminase deficiency with a novel synonymous mutation and a case series from China.

    Delayed-onset adenosine deaminase deficiency with a novel synonymous mutation and a case series from China.
    Zhang Y, Liu W, Shu Z, Li Y, Sun F, Li ZG, Han TX, Mao HW, Wang TY.

    08/25/2023
    Identification of ADA as a Biomarker for Atypical Epstein Barr Virus Infection in Children.

    Identification of ADA as a Biomarker for Atypical Epstein Barr Virus Infection in Children.
    Shi T, Huang L, Zhang W, Shi W, Wu J, Bian Y, Jiang Y, Tian J.

    07/12/2023
    Correlation of serum adenosine deaminase activity with disease activity in patients with primary Sjogren's syndrome.

    Correlation of serum adenosine deaminase activity with disease activity in patients with primary Sjögren's syndrome.
    Zhang H, Ye H, Xu Z, Dong K, Wang Y, Geng L, Wang S.

    06/1/2023
    Adenosine deaminase from the cerebrospinal fluid for the diagnosis of tuberculous meningitis: A meta-analysis.

    Adenosine deaminase from the cerebrospinal fluid for the diagnosis of tuberculous meningitis: A meta-analysis.
    Ye Q, Yan W.

    03/24/2023
    Serum adenosine deaminase activity and acute cerebral infarction: a retrospective case-control study based on 7913 participants.

    Serum adenosine deaminase activity and acute cerebral infarction: a retrospective case-control study based on 7913 participants.
    Ling Y, Jiang C, Xiao Z, Shang X, Li Q, Wang B, Hao M, Liu F, Zhao N, Feng J, Zhao H., Free PMC Article

    12/3/2022
    The diagnostic value of T cell spot test and adenosine deaminase in pleural effusion for tuberculous pleurisy: A systematic review and meta-analysis.

    The diagnostic value of T cell spot test and adenosine deaminase in pleural effusion for tuberculous pleurisy: A systematic review and meta-analysis.
    Zhang X, Meng Q, Miao R, Huang P.

    08/20/2022
    Does the adenosine deaminase (ADA) gene confer risk of sleepwalking?

    Does the adenosine deaminase (ADA) gene confer risk of sleepwalking?
    Fournier S, Dauvilliers Y, Warby SC, Labrecque M, Zadra A, Boucetta S, El Gewely M, Kaddioui H, Lopez R, Montplaisir JY, Bareke E, Tétreault M, Desautels A.

    08/6/2022
    Citrullination of adenosine deaminase impairs its binding to dipeptidyl peptidase IV.

    Citrullination of adenosine deaminase impairs its binding to dipeptidyl peptidase IV.
    Karapetyan L, Sharoyan S, Mardanyan S, Lupidi G, Cuccioloni M, Angeletti M, Markarian S, Shilajyan H, Antonyan A.

    06/18/2022
    Catalytically active holo Homo sapiens adenosine deaminase I adopts a closed conformation.

    Catalytically active holo Homo sapiens adenosine deaminase I adopts a closed conformation.
    Ma MT, Jennings MR, Blazeck J, Lieberman RL., Free PMC Article

    03/26/2022
    ADA gene haplotype is associated with coronary-in-stent-restenosis.

    ADA gene haplotype is associated with coronary-in-stent-restenosis.
    Gholami M, Borhan Dayani S, Mehrpooya M, Amoli MM.

    01/29/2022
    A Single Nucleotide ADA Genetic Variant Is Associated to Central Inflammation and Clinical Presentation in MS: Implications for Cladribine Treatment.

    A Single Nucleotide ADA Genetic Variant Is Associated to Central Inflammation and Clinical Presentation in MS: Implications for Cladribine Treatment.
    Stampanoni Bassi M, Buttari F, Simonelli I, Gilio L, Furlan R, Finardi A, Marfia GA, Visconti A, Paolillo A, Storto M, Gambardella S, Ferese R, Salvetti M, Uccelli A, Matarese G, Centonze D, De Vito F., Free PMC Article

    07/24/2021
    Adenosine Deaminase as a Biomarker of Tenofovir Mediated Inflammation in Naive HIV Patients.

    Adenosine Deaminase as a Biomarker of Tenofovir Mediated Inflammation in Naïve HIV Patients.
    Conesa-Buendía FM, Llamas-Granda P, Atencio P, Cabello A, Górgolas M, Largo R, Herrero-Beaumont G, Mediero A., Free PMC Article

    02/13/2021
    Clinical value of combined detection of reactive oxygen species modulator 1 and adenosine deaminase in pleural effusion in the identification of NSCLC associated malignant pleural effusion.

    Clinical value of combined detection of reactive oxygen species modulator 1 and adenosine deaminase in pleural effusion in the identification of NSCLC associated malignant pleural effusion.
    Zhang F, Wang J, Fu J, Hu L, Zheng X, Wang Y, Chen B., Free PMC Article

    12/19/2020
    A Novel Non-frameshift ADA Deletion Detected by Whole Exome Sequencing in an Iranian Family with Severe Combined Immunodeficiency.

    A Novel Non-frameshift ADA Deletion Detected by Whole Exome Sequencing in an Iranian Family with Severe Combined Immunodeficiency.
    Talebi T, Biglari A, Shahroeei M, Changi-Ashtiani M, Dinmohammadi H, Navabi SS, Parvaneh N, Bossuyt X, Shahani T, Rokni-Zadeh H.

    12/5/2020
    Exploring the binding modes of cordycepin to human adenosine deaminase 1 (ADA1) compared to adenosine and 2'-deoxyadenosine.

    Exploring the binding modes of cordycepin to human adenosine deaminase 1 (ADA1) compared to adenosine and 2'-deoxyadenosine.
    Niramitranon J, Pongprayoon P.

    10/10/2020
    A significant difference existed in pleural effusion ADA levels between malignant pleural mesothelioma (MPM) and benign disease patients. Pleural effusion ADA levels were significantly higher in MPM patients.

    Adenosine Deaminase in Pleural Effusion and Its Relationship with Clinical Parameters in Patients with Malignant Pleural Mesothelioma.
    Nakajima Y, Kuribayashi K, Ishigaki H, Tada A, Negi Y, Minami T, Takahashi R, Doi H, Kitajima K, Yokoi T, Kijima T.

    08/1/2020
    Inhibition of eADA blocked endothelial activation suggesting a crucial role of this enzyme in the control of vascular inflammation. This supports the concept of eADA targeted vascular protection therapy

    Inhibition of LPS-stimulated ecto-adenosine deaminase attenuates endothelial cell activation.
    Kutryb-Zajac B, Mierzejewska P, Sucajtys-Szulc E, Bulinska A, Zabielska MA, Jablonska P, Serocki M, Koszalka P, Milczarek R, Jasztal A, Bartoszewski R, Chlopicki S, Slominska EM, Smolenski RT.

    06/20/2020
    Increased serum ADA activity as well as its association with obesity in Polycystic Ovary Syndrome (PCOS), while there was no change in serum DPP-4 activity in women with PCOS.

    Serum activities of dipeptidyl peptidase-4 and adenosine deaminase in polycystic ovary syndrome: association with obesity.
    Kahraman S, Eroglu Altinova A, Elgun S, Yalcin MM, Aktas Yilmaz B, Ozkan C, Akturk M, Balos Toruner F.

    01/25/2020
    sequential detection of ADA screening and T-SPOT assay was found to be an accurate and rapid method for identifying TB pleurisy from pleural effusion

    The diagnostic effect of sequential detection of ADA screening and T-SPOT assay in pleural effusion patients.
    Feng M, Sun F, Wang F, Cao G.

    01/4/2020
    GLT would confer protection against renal injury by protecting against lipid accumulation and glutathione depletion, at least in part, through suppression of ADA/XO/UA pathway.

    Glutamine confers renoprotection by normalizing lipid and glutathione content in insulin-resistant pregnant rats.
    Olaniyi KS, Olatunji LA.

    09/14/2019
    ADA levels were found to be increased in polycystic ovary syndrome patients compared to controls.

    Dipeptidyl peptidase-4 and adenosine deaminase enzyme levels in polycystic ovary syndrome.
    Öztürk B, Gürbüz AS, Durak ZE, Öztürk HS.

    08/17/2019
    Alanine scanning results showed that His17, Gly184, Asp295, and Asp296 exerted the greatest effects on protein energy, suggesting that they played crucial roles in binding to inhibitors.

    Probing inhibition mechanisms of adenosine deaminase by using molecular dynamics simulations.
    Tian X, Liu Y, Zhu J, Yu Z, Han J, Wang Y, Han W., Free PMC Article

    04/27/2019
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