| Role of HDAC5 Epigenetics in Chronic Craniofacial Neuropathic Pain. | Role of HDAC5 Epigenetics in Chronic Craniofacial Neuropathic Pain.
Hui SE, Westlund KN., Free PMC Article | 07/18/2024 |
| Histone Trimethylations and HDAC5 Regulate Spheroid Subpopulation and Differentiation Signaling of Human Adipose-Derived Stem Cells. | Histone Trimethylations and HDAC5 Regulate Spheroid Subpopulation and Differentiation Signaling of Human Adipose-Derived Stem Cells.
Chang MM, Hong YK, Hsu CK, Harn HI, Huang BM, Liu YH, Lu FI, Hsueh YY, Lin SP, Wu CC., Free PMC Article | 03/18/2024 |
| NFYB increases chemosensitivity in glioblastoma by promoting HDAC5-mediated transcriptional inhibition of SHMT2. | NFYB increases chemosensitivity in glioblastoma by promoting HDAC5-mediated transcriptional inhibition of SHMT2.
Zhang Y, Huang H, Liu P, Xie Y. | 10/25/2023 |
| HDAC5 Loss Enhances Phospholipid-Derived Arachidonic Acid Generation and Confers Sensitivity to cPLA2 Inhibition in Pancreatic Cancer. | HDAC5 Loss Enhances Phospholipid-Derived Arachidonic Acid Generation and Confers Sensitivity to cPLA2 Inhibition in Pancreatic Cancer.
Pan P, Qin G, Wang B, Yu H, Chen J, Liu J, Bing K, Shen J, Ren D, Zhao Y, Xia W, Li H, Wu H, Zhou Y., Free PMC Article | 12/24/2022 |
| METTL3-mediated N6-methyladenosine modification and HDAC5/YY1 promote IFFO1 downregulation in tumor development and chemo-resistance. | METTL3-mediated N6-methyladenosine modification and HDAC5/YY1 promote IFFO1 downregulation in tumor development and chemo-resistance.
Zhang Y, Qiu JG, Jia XY, Ke Y, Zhang MK, Stieg D, Liu WJ, Liu LZ, Wang L, Jiang BH. | 12/3/2022 |
| HDAC5 inactivates CYR61-regulated CD31/mTOR axis to prevent the occurrence of preeclampsia. | HDAC5 inactivates CYR61-regulated CD31/mTOR axis to prevent the occurrence of preeclampsia.
Jiang P, Ying X, Li Z, Jiang R, Zhou J, Zhang M, Yang X, Zhu X. | 11/12/2022 |
| HDAC5-mediated Smad7 silencing through MEF2A is critical for fibroblast activation and hypertrophic scar formation. | HDAC5-mediated Smad7 silencing through MEF2A is critical for fibroblast activation and hypertrophic scar formation.
Gao Y, Liu Y, Zheng D, Ho C, Wen D, Sun J, Huang L, Liu Y, Li Q, Zhang Y., Free PMC Article | 10/29/2022 |
| Epigenetic master regulators HDAC1 and HDAC5 control pathobiont Enterobacteria colonization in ileal mucosa of Crohn's disease patients. | Epigenetic master regulators HDAC1 and HDAC5 control pathobiont Enterobacteria colonization in ileal mucosa of Crohn's disease patients.
Chervy M, Sivignon A, Dambrine F, Buisson A, Sauvanet P, Godfraind C, Allez M, Le Bourhis L, The Remind Group, Barnich N, Denizot J., Free PMC Article | 10/8/2022 |
| HDAC5, negatively regulated by miR-148a-3p, promotes colon cancer cell migration. | HDAC5, negatively regulated by miR-148a-3p, promotes colon cancer cell migration.
OuYang C, Shu G, Liu J, Deng S, Lu P, Li Y, Gan Y, Xie B, Liu J, Yin G., Free PMC Article | 08/13/2022 |
| HDAC5 modulates PD-L1 expression and cancer immunity via p65 deacetylation in pancreatic cancer. | HDAC5 modulates PD-L1 expression and cancer immunity via p65 deacetylation in pancreatic cancer.
Zhou Y, Jin X, Yu H, Qin G, Pan P, Zhao J, Chen T, Liang X, Sun Y, Wang B, Ren D, Zhu S, Wu H., Free PMC Article | 04/30/2022 |
| Histone deacetylase 5 deacetylates the phosphatase PP2A for positively regulating NF-kappaB signaling. | Histone deacetylase 5 deacetylates the phosphatase PP2A for positively regulating NF-κB signaling.
Xu C, Tang J, Yang Q, Zhao H, Liu Y, Cao J, Zhou Y, Chen X, Chen J., Free PMC Article | 01/29/2022 |
| Impairment of human terminal erythroid differentiation by histone deacetylase 5 deficiency. | Impairment of human terminal erythroid differentiation by histone deacetylase 5 deficiency.
Wang Y, Li W, Schulz VP, Zhao H, Qu X, Qi Q, Cheng Y, Guo X, Zhang S, Wei X, Liu D, Yazdanbakhsh K, Hillyer CD, Mohandas N, Chen L, Gallagher PG, An X., Free PMC Article | 12/11/2021 |
| Neddylation Regulates Class IIa and III Histone Deacetylases to Mediate Myoblast Differentiation. | Neddylation Regulates Class IIa and III Histone Deacetylases to Mediate Myoblast Differentiation.
Zhou H, Su H, Chen W., Free PMC Article | 10/23/2021 |
| METTL14-regulated PI3K/Akt signaling pathway via PTEN affects HDAC5-mediated epithelial-mesenchymal transition of renal tubular cells in diabetic kidney disease. | METTL14-regulated PI3K/Akt signaling pathway via PTEN affects HDAC5-mediated epithelial-mesenchymal transition of renal tubular cells in diabetic kidney disease.
Xu Z, Jia K, Wang H, Gao F, Zhao S, Li F, Hao J., Free PMC Article | 09/18/2021 |
| HDAC5 promotes intestinal sepsis via the Ghrelin/E2F1/NF-kappaB axis. | HDAC5 promotes intestinal sepsis via the Ghrelin/E2F1/NF-κB axis.
Li B, Zhang L, Zhu L, Cao Y, Dou Z, Yu Q. | 07/24/2021 |
| HDAC5 Loss Impairs RB Repression of Pro-Oncogenic Genes and Confers CDK4/6 Inhibitor Resistance in Cancer. | HDAC5 Loss Impairs RB Repression of Pro-Oncogenic Genes and Confers CDK4/6 Inhibitor Resistance in Cancer.
Zhou Y, Jin X, Ma J, Ding D, Huang Z, Sheng H, Yan Y, Pan Y, Wei T, Wang L, Wu H, Huang H. | 06/26/2021 |
| Whole Exome Sequencing Identifies APCDD1 and HDAC5 Genes as Potentially Cancer Predisposing in Familial Colorectal Cancer. | Whole Exome Sequencing Identifies APCDD1 and HDAC5 Genes as Potentially Cancer Predisposing in Familial Colorectal Cancer.
Skopelitou D, Miao B, Srivastava A, Kumar A, Kuswick M, Dymerska D, Paramasivam N, Schlesner M, Lubinski J, Hemminki K, Försti A, Bandapalli OR., Free PMC Article | 04/17/2021 |
| HDAC4 and 5 repression of TBX5 is relieved by protein kinase D1. | HDAC4 and 5 repression of TBX5 is relieved by protein kinase D1.
Ghosh TK, Aparicio-Sánchez JJ, Buxton S, Brook JD., Free PMC Article | 11/21/2020 |
| This study reveals that HDAC5 regulated by C-MYC is essential for SOX9 deacetylation and nuclear localisation, which is critical for tamoxifen resistance. These results indicate a potential therapy strategy for ER(+) breast cancer by targeting C-MYC/HDAC5/SOX9 axis. | HDAC5-mediated deacetylation and nuclear localisation of SOX9 is critical for tamoxifen resistance in breast cancer.
Xue Y, Lian W, Zhi J, Yang W, Li Q, Guo X, Gao J, Qu H, Lin W, Li Z, Lai L, Wang Q., Free PMC Article | 06/20/2020 |
| HDAC5 overexpression in urothelial carcinoma cell lines decreases cell proliferation but can promote epithelial-to-mesenchymal transition. | HDAC5 Expression in Urothelial Carcinoma Cell Lines Inhibits Long-Term Proliferation but Can Promote Epithelial-to-Mesenchymal Transition.
Jaguva Vasudevan AA, Hoffmann MJ, Beck MLC, Poschmann G, Petzsch P, Wiek C, Stühler K, Köhrer K, Schulz WA, Niegisch G., Free PMC Article | 08/17/2019 |
| It identified BMAL1 as a cAMP-responsive coactivator of HDAC5 to regulate hepatic gluconeogenesis | BMAL1 functions as a cAMP-responsive coactivator of HDAC5 to regulate hepatic gluconeogenesis.
Li J, Lv S, Qiu X, Yu J, Jiang J, Jin Y, Guo W, Zhao R, Zhang ZN, Zhang C, Luan B., Free PMC Article | 07/20/2019 |
| in hISMC from resected Crohn's strictures, we observed a significantly reduced contractile phenotype compared with patient-matched intrinsic controls that was associated with increased patient-specific expression of DNA methyltransferase 1, HDAC2, and HDAC5. | Epigenetic modification of intestinal smooth muscle cell phenotype during proliferation.
Bonafiglia QA, Lourenssen SR, Hurlbut DJ, Blennerhassett MG. | 07/6/2019 |
| Latent autoimmune diabetes of adults (LADA) patients showed stronger binding of p-STAT3, HDAC5 and DNMT1 than controls. | STAT3-mediated epigenetic silencing of FOXP3 in LADA T cells is regulated through HDAC5 and DNMT1.
Hou C, Zhong Y, Wang Z, Ming Z, Huang G, Ouyang L, Li Y, Lu Q, Zhou Z. | 07/6/2019 |
| HDAC5 expression was positively correlated with miR-2861 in lung cancer stem cells (LCSCs), and knockdown of miR-2861 decreased the expression of HDAC5, which implied that HDAC5 may be involved in the differentiation of LCSCs mediated by miR-2861. | MiR-2861 Behaves as a Biomarker of Lung Cancer Stem Cells and Regulates the HDAC5-ERK System Genes.
Zhao M, Li L, Zhou J, Cui X, Tian Q, Jin Y, Zhu Y. | 04/20/2019 |
| These results demonstrate a previously unknown negative epigenetic regulation of hematopoietic stem cells (HSC) homing and engraftment by HDAC5, and allow for a new and simple translational strategy to enhance HSC transplantation. | Neutralizing negative epigenetic regulation by HDAC5 enhances human haematopoietic stem cell homing and engraftment.
Huang X, Guo B, Liu S, Wan J, Broxmeyer HE., Free PMC Article | 12/22/2018 |