| Palmitoylation of vacuole membrane protein 1 promotes small extracellular vesicle secretion via interaction with ALIX and influences intercellular communication. | Palmitoylation of vacuole membrane protein 1 promotes small extracellular vesicle secretion via interaction with ALIX and influences intercellular communication.
Qu M, Liu X, Wang X, Li Z, Zhou L, Li H., Free PMC Article | 04/17/2024 |
| SUMOylation-triggered ALIX activation modulates extracellular vesicles circTLCD4-RWDD3 to promote lymphatic metastasis of non-small cell lung cancer. | SUMOylation-triggered ALIX activation modulates extracellular vesicles circTLCD4-RWDD3 to promote lymphatic metastasis of non-small cell lung cancer.
Diao X, Guo C, Zheng H, Zhao K, Luo Y, An M, Lin Y, Chen J, Li Y, Li Y, Gao X, Zhang J, Zhou M, Bai W, Liu L, Wang G, Zhang L, He X, Zhang R, Li Z, Chen C, Li S., Free PMC Article | 11/27/2023 |
| ALIX promotes cell migration and invasion of head and neck squamous cell carcinoma by regulating the expression of MMP9, MMP14, VEGF-C. | ALIX promotes cell migration and invasion of head and neck squamous cell carcinoma by regulating the expression of MMP9, MMP14, VEGF-C.
Xie QH, Wang WM, Yang JG, Xia HF, Xiao BL, Chen GH, Huang J, Li RF, Chen G. | 05/17/2023 |
| miR3633p attenuates the oxygenglucose deprivation/reoxygenationinduced neuronal injury in vitro by targeting PDCD6IP. | miR‑363‑3p attenuates the oxygen‑glucose deprivation/reoxygenation‑induced neuronal injury in vitro by targeting PDCD6IP.
Wang Y, Jin J, Xia Z, Chen H., Free PMC Article | 09/10/2022 |
| Roles of ESCRT Proteins ALIX and CHMP4A and Their Interplay with Interferon-Stimulated Gene 15 during Tick-Borne Flavivirus Infection. | Roles of ESCRT Proteins ALIX and CHMP4A and Their Interplay with Interferon-Stimulated Gene 15 during Tick-Borne Flavivirus Infection.
Tran PT, Chiramel AI, Johansson M, Melik W., Free PMC Article | 03/5/2022 |
| Mechanistic roles of tyrosine phosphorylation in reversible amyloids, autoinhibition, and endosomal membrane association of ALIX. | Mechanistic roles of tyrosine phosphorylation in reversible amyloids, autoinhibition, and endosomal membrane association of ALIX.
Elias RD, Ramaraju B, Deshmukh L., Free PMC Article | 12/18/2021 |
| Structural Insight into the Interaction of Sendai Virus C Protein with Alix To Stimulate Viral Budding. | Structural Insight into the Interaction of Sendai Virus C Protein with Alix To Stimulate Viral Budding.
Oda K, Matoba Y, Sugiyama M, Sakaguchi T., Free PMC Article | 10/16/2021 |
| PDCD6IP, encoding a regulator of the ESCRT complex, is mutated in microcephaly. | PDCD6IP, encoding a regulator of the ESCRT complex, is mutated in microcephaly.
Khan A, Alaamery M, Massadeh S, Obaid A, Kashgari AA, Walsh CA, Eyaid W., Free PMC Article | 07/10/2021 |
| Occludin, caveolin-1, and Alix form a multi-protein complex and regulate HIV-1 infection of brain pericytes. | Occludin, caveolin-1, and Alix form a multi-protein complex and regulate HIV-1 infection of brain pericytes.
Torices S, Roberts SA, Park M, Malhotra A, Toborek M., Free PMC Article | 04/24/2021 |
| ESCRT-III controls nuclear envelope deformation induced by progerin. | ESCRT-III controls nuclear envelope deformation induced by progerin.
Arii J, Maeda F, Maruzuru Y, Koyanagi N, Kato A, Mori Y, Kawaguchi Y., Free PMC Article | 03/6/2021 |
| Alix and Syntenin-1 direct amyloid precursor protein trafficking into extracellular vesicles. | Alix and Syntenin-1 direct amyloid precursor protein trafficking into extracellular vesicles.
Cone AS, Hurwitz SN, Lee GS, Yuan X, Zhou Y, Li Y, Meckes DG Jr., Free PMC Article | 02/6/2021 |
| Proline-rich domain of human ALIX contains multiple TSG101-UEV interaction sites and forms phosphorylation-mediated reversible amyloids. | Proline-rich domain of human ALIX contains multiple TSG101-UEV interaction sites and forms phosphorylation-mediated reversible amyloids.
Elias RD, Ma W, Ghirlando R, Schwieters CD, Reddy VS, Deshmukh L., Free PMC Article | 12/19/2020 |
| Alix-Mediated Rescue of Feline Immunodeficiency Virus Budding Differs from That Observed with Human Immunodeficiency Virus. | Alix-Mediated Rescue of Feline Immunodeficiency Virus Budding Differs from That Observed with Human Immunodeficiency Virus.
Del Vecchio C, Celestino M, Celegato M, Palù G, Parolin C, Bouamr F, Calistri A., Free PMC Article | 10/24/2020 |
| ALIX- and ESCRT-III-dependent sorting of tetraspanins to exosomes. | ALIX- and ESCRT-III-dependent sorting of tetraspanins to exosomes.
Larios J, Mercier V, Roux A, Gruenberg J., Free PMC Article | 10/24/2020 |
| Direct interactions between ALIX, syntenin and syndecan-4 are essential for proper enrichment of the ESCRT-III machinery at the cytokinetic abscission site. | The Flemmingsome reveals an ESCRT-to-membrane coupling via ALIX/syntenin/syndecan-4 required for completion of cytokinesis.
Addi C, Presle A, Frémont S, Cuvelier F, Rocancourt M, Milin F, Schmutz S, Chamot-Rooke J, Douché T, Duchateau M, Giai Gianetto Q, Salles A, Ménager H, Matondo M, Zimmermann P, Gupta-Rossi N, Echard A., Free PMC Article | 08/1/2020 |
| analysis of how flotillin-mediated endocytosis and ALIX-syntenin-1-mediated exocytosis protect the cell membrane from damage caused by necroptosis | Flotillin-mediated endocytosis and ALIX-syntenin-1-mediated exocytosis protect the cell membrane from damage caused by necroptosis.
Fan W, Guo J, Gao B, Zhang W, Ling L, Xu T, Pan C, Li L, Chen S, Wang H, Zhang J, Wang X. | 07/11/2020 |
| ALIX knockout and overexpression regulate protein profile in induced pluripotent stem cells-derived exosome. | ALIX increases protein content and protective function of iPSC-derived exosomes.
Sun R, Liu Y, Lu M, Ding Q, Wang P, Zhang H, Tian X, Lu P, Meng D, Sun N, Xiang M, Chen S. | 06/20/2020 |
| These results, for the first time, indicate that CCL2 mediates ALIX mobilization from F-actin and enhances Gag-p6 mediated HIV-1 release and fitness. | CCL2 mobilizes ALIX to facilitate Gag-p6 mediated HIV-1 virion release.
Ajasin DO, Rao VR, Wu X, Ramasamy S, Pujato M, Ruiz AP, Fiser A, Bresnick AR, Kalpana GV, Prasad VR., Free PMC Article | 02/22/2020 |
| data suggest that PYxE insertion in Gag restores the ability of Gag to bind ALIX and correlates with enhanced viral fitness in the absence or presence of LPV and TAF. The high prevalence and increased replication fitness of the HIV-1C virus with PYxE insertion indicates the clinical importance of these viral variants. | HIV-1 Subtype C with PYxE Insertion Has Enhanced Binding of Gag-p6 to Host Cell Protein ALIX and Increased Replication Fitness.
van Domselaar R, Njenda DT, Rao R, Sönnerborg A, Singh K, Neogi U., Free PMC Article | 02/1/2020 |
| ALIX is a regulator of both EGFR activity and PD-L1 surface presentation in basal-like breast cancer (BLBC) cells. | ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation.
Monypenny J, Milewicz H, Flores-Borja F, Weitsman G, Cheung A, Chowdhury R, Burgoyne T, Arulappu A, Lawler K, Barber PR, Vicencio JM, Keppler M, Wulaningsih W, Davidson SM, Fraternali F, Woodman N, Turmaine M, Gillett C, Franz D, Quezada SA, Futter CE, Von Kriegsheim A, Kolch W, Vojnovic B, Carlton JG, Ng T., Free PMC Article | 12/7/2019 |
| Alix serves as a co-factor for the interaction between the E3-ubiquitin ligase NEDD4-1 and the ABC transporter targets, ABCG1 and ABCG4. | The Adaptor Protein Alix is Involved in the Interaction Between the Ubiquitin Ligase NEDD4-1 and its Targets, ABCG1 and ABCG4.
Alrosan A, Aleidi SM, Yang A, Brown AJ, Gelissen IC., Free PMC Article | 11/23/2019 |
| In summary, these data reveal the functional role of PYRE motif insertion towards the cooperative mechanism of ALIX/Nedd4-1 in HIV-1 release in the absence of PTAP/Tsg101 pathway. | PYRE insertion within HIV-1 subtype C p6-Gag functions as an ALIX-dependent late domain.
Chaturbhuj D, Patil A, Gangakhedkar R., Free PMC Article | 10/12/2019 |
| The results showed that ALIX both interacted and co-localized with Dengue virus NS3 protein and that upregulation of ALIX resulted in a significantly increased viral titer, while either siRNA or CRISPR-Cas9 mediated down regulation of ALIX significantly reduced viral production. | Dengue virus requires apoptosis linked gene-2-interacting protein X (ALIX) for viral propagation.
Thepparit C, Khongwichit S, Ketsuwan K, Libsittikul S, Auewarakul P, Smith DR. | 03/2/2019 |
| our results identify the CD63-syntenin-1-ALIX complex as a key regulatory component in post-endocytic HPV trafficking. | The CD63-Syntenin-1 Complex Controls Post-Endocytic Trafficking of Oncogenic Human Papillomaviruses.
Gräßel L, Fast LA, Scheffer KD, Boukhallouk F, Spoden GA, Tenzer S, Boller K, Bago R, Rajesh S, Overduin M, Berditchevski F, Florin L., Free PMC Article | 05/26/2018 |
| Alix acts in concert with endophilin A to promote clathrin-independent endocytosis of cholera toxin and to regulate cell migration. | ALG-2 interacting protein-X (Alix) is essential for clathrin-independent endocytosis and signaling.
Mercier V, Laporte MH, Destaing O, Blot B, Blouin CM, Pernet-Gallay K, Chatellard C, Saoudi Y, Albiges-Rizo C, Lamaze C, Fraboulet S, Petiot A, Sadoul R., Free PMC Article | 04/7/2018 |