| Five siblings expand the spectrum of GPC6-related skeletal dysplasia. | Five siblings expand the spectrum of GPC6-related skeletal dysplasia.
Crenshaw MM, Meyers ML, Brown K, Slegesky V, Duis J, Elias ER, Saenz M, Shi W, Filmus J, Meeks NJL. | 09/23/2023 |
| Prognostic value of GPC5 polymorphism rs2352028 and clinical characteristics in Chinese lung cancer patients. | Prognostic value of GPC5 polymorphism rs2352028 and clinical characteristics in Chinese lung cancer patients.
Wang F, Li Y, Li Z, Zou Z, Lu Y, Xu C, Zhao Z, Wang H, Wang Y, Guo S, Jin L, Wang J, Li Q, Jiang G, Xia F, Shen B, Wu J. | 10/22/2022 |
| TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6. | TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6.
Lehmkuhl EM, Loganathan S, Alsop E, Blythe AD, Kovalik T, Mortimore NP, Barrameda D, Kueth C, Eck RJ, Siddegowda BB, Joardar A, Ball H, Macias ME, Bowser R, Van Keuren-Jensen K, Zarnescu DC., Free PMC Article | 11/13/2021 |
| Can Glypican-6 Level Predict Ejection Fraction Decline After Myocardial Infarction? | Can Glypican-6 Level Predict Ejection Fraction Decline After Myocardial Infarction?
Ozturk F, Atici A, Barman HA. | 06/26/2021 |
| Hedgehog signaling activation required for glypican-6-mediated regulation of invasion, migration, and epithelial-mesenchymal transition of gastric cancer cells. | Hedgehog signaling activation required for glypican-6-mediated regulation of invasion, migration, and epithelial-mesenchymal transition of gastric cancer cells.
Zeng C, Yan R, Yang G, Xiang S, Zhao F., Free PMC Article | 03/27/2021 |
| GPC6 rs4773724 was associated with a decreased risk of LDH in allele model (OR = 0.82, 95% CI: 0.68-0.98, p = 0.026), whereas rs1008993 increased the LDH risk (OR = 1.34, 95% CI: 1.05-1.71, p = 0.020). rs4773724 and rs9523981 were associated with susceptibility of LDH among individuals whose age are less than 45. And rs1008993 was associated with increased LDH risk in males. | Association of glypican-6 polymorphisms with lumbar disk herniation risk in the Han Chinese population.
Hu B, Xing W, Li F, Huang Z, Zheng W, Ji D, Niu F, Zhu Y, Yang X., Free PMC Article | 07/18/2020 |
| findings identified GPC6 as an early biomarker for melanoma metastatic progression, one that can be regulated by miR-509-3p. | Glypican 6 is a putative biomarker for metastatic progression of cutaneous melanoma.
Li Y, Li M, Shats I, Krahn JM, Flake GP, Umbach DM, Li X, Li L., Free PMC Article | 02/15/2020 |
| Thus, GPC6 and TMEM132D may serve as predictors of CD8+ T-lymphocyte infiltration and as favorable prognostic markers in early stage ovarian cancer with important consequences for diagnosis. | Overexpression of GPC6 and TMEM132D in Early Stage Ovarian Cancer Correlates with CD8+ T-Lymphocyte Infiltration and Increased Patient Survival.
Karapetsas A, Giannakakis A, Dangaj D, Lanitis E, Kynigopoulos S, Lambropoulou M, Tanyi JL, Galanis A, Kakolyris S, Trypsianis G, Coukos G, Sandaltzopoulos R., Free PMC Article | 07/30/2016 |
| Extracellular matrix proteins expression profiling in chemoresistant variants of the A2780 ovarian cancer cell line. | Extracellular matrix proteins expression profiling in chemoresistant variants of the A2780 ovarian cancer cell line.
Januchowski R, Zawierucha P, Ruciński M, Nowicki M, Zabel M., Free PMC Article | 02/14/2015 |
| GPC6 promotes invasive migration by inhibition of canonical beta-catenin and Wnt signalling, and up-regulation of non-canonical Wnt5A signalling leading to the activation of JNK and p38 MAPK. | NFAT promotes carcinoma invasive migration through glypican-6.
Yiu GK, Kaunisto A, Chin YR, Toker A., Free PMC Article | 12/24/2011 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | A genome-wide association study of neuroticism in a population-based sample.
Calboli FC, Tozzi F, Galwey NW, Antoniades A, Mooser V, Preisig M, Vollenweider P, Waterworth D, Waeber G, Johnson MR, Muglia P, Balding DJ., Free PMC Article | 09/15/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| a reduction in GPC6 mRNA in retinoblastoma is associated with the non-random allelic loss at 13q31 that could contribute to RB development. | Allelic imbalance at 13q31 is associated with reduced GPC6 in Chinese with sporadic retinoblastoma.
Lau CS, Yu CB, Wong HK, Fan DS, Mak HT, Wong KW, Lam DS, Pang CP, Choy KW. | 05/31/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesAssociation to the Glypican-5 gene in multiple sclerosis.
Lorentzen AR, Melum E, Ellinghaus E, Smestad C, Mero IL, Aarseth JH, Myhr KM, Celius EG, Lie BA, Karlsen TH, Franke A, Harbo HF. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.
Wheeler HE, Metter EJ, Tanaka T, Absher D, Higgins J, Zahn JM, Wilhelmy J, Davis RW, Singleton A, Myers RM, Ferrucci L, Kim SK. | 12/2/2009 |
| Mutations in the heparan-sulfate proteoglycan glypican 6 impair endochondral ossification and cause recessive omodysplasia | Mutations in the heparan-sulfate proteoglycan glypican 6 (GPC6) impair endochondral ossification and cause recessive omodysplasia.
Campos-Xavier AB, Martinet D, Bateman J, Belluoccio D, Rowley L, Tan TY, Baxová A, Gustavson KH, Borochowitz ZU, Innes AM, Unger S, Beckmann JS, Mittaz L, Ballhausen D, Superti-Furga A, Savarirayan R, Bonafé L., Free PMC Article | 01/21/2010 |