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    PPIF peptidylprolyl isomerase F [ Homo sapiens (human) ]

    Gene ID: 10105, updated on 4-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Dissecting prostate Cancer: Single-Cell insight into Macrophage Diversity, molecular Prognosticators, and the role of Peptidylprolyl Isomerase F.

    Dissecting prostate Cancer: Single-Cell insight into Macrophage Diversity, molecular Prognosticators, and the role of Peptidylprolyl Isomerase F.
    Guan B, Huang C, Meng L, Zhang S, Liu Q, Wang X, Li X, Hao Z.

    07/30/2024
    Mitochondrial CypD Acetylation Promotes Endothelial Dysfunction and Hypertension.

    Mitochondrial CypD Acetylation Promotes Endothelial Dysfunction and Hypertension.
    Dikalova A, Fehrenbach D, Mayorov V, Panov A, Ao M, Lantier L, Amarnath V, Lopez MG, Billings FT 4th, Sack MN, Dikalov S.,

    05/31/2024
    Role of the mitochondrial protein cyclophilin D in skin wound healing and collagen secretion.

    Role of the mitochondrial protein cyclophilin D in skin wound healing and collagen secretion.
    Bansal R, Torres M, Hunt M, Wang N, Chatzopoulou M, Manchanda M, Taddeo EP, Shu C, Shirihai OS, Bachar-Wikstrom E, Wikstrom JD., Free PMC Article

    05/10/2024
    Cinnamtannin B-1 Inhibits the Progression of Osteosarcoma by Regulating the miR-1281/PPIF Axis.

    Cinnamtannin B-1 Inhibits the Progression of Osteosarcoma by Regulating the miR-1281/PPIF Axis.
    Jia J, Xia J, Liu W, Tao F, Xiao J.

    01/14/2023
    Formation of High-Conductive C Subunit Channels upon Interaction with Cyclophilin D.

    Formation of High-Conductive C Subunit Channels upon Interaction with Cyclophilin D.
    Amodeo GF, Krilyuk N, Pavlov EV., Free PMC Article

    01/1/2022
    Overexpression of TICRR and PPIF confer poor prognosis in endometrial cancer identified by gene co-expression network analysis.

    Overexpression of TICRR and PPIF confer poor prognosis in endometrial cancer identified by gene co-expression network analysis.
    Yang L, Cui Y, Sun X, Wang Y., Free PMC Article

    08/21/2021
    microRNA-1203 targets and silences cyclophilin D to protect human endometrial cells from oxygen and glucose deprivation-re-oxygenation.

    microRNA-1203 targets and silences cyclophilin D to protect human endometrial cells from oxygen and glucose deprivation-re-oxygenation.
    Xu HB, Zheng YF, Wu D, Li Y, Zhou LN, Chen YG., Free PMC Article

    01/23/2021
    RNase T1 Refolding Assay for Determining Mitochondrial Cyclophilin D Activity: A Novel In Vitro Method Applicable in Drug Research and Discovery.

    RNase T1 Refolding Assay for Determining Mitochondrial Cyclophilin D Activity: A Novel In Vitro Method Applicable in Drug Research and Discovery.
    Zemanova L, Vaskova M, Schmidt M, Roubalova J, Haleckova A, Benek O, Musilek K.

    01/9/2021
    Targeting cyclophilin-D by miR-1281 protects human macrophages from Mycobacterium tuberculosis-induced programmed necrosis and apoptosis.

    Targeting cyclophilin-D by miR-1281 protects human macrophages from Mycobacterium tuberculosis-induced programmed necrosis and apoptosis.
    Sun Q, Shen X, Wang P, Ma J, Sha W., Free PMC Article

    11/21/2020
    the important yet enigmatic nature of CyPD (PPIF) somehow makes it a master regulator, yet a troublemaker, for mitochondrial function.

    Cyclophilin D, Somehow a Master Regulator of Mitochondrial Function.
    Porter GA Jr, Beutner G., Free PMC Article

    06/8/2019
    Data show that show that the molecular chaperone heat shock protein 60 (Hsp60) directly associates with cyclophilin D (CypD).

    Heat shock protein 60 regulation of the mitochondrial permeability transition pore in tumor cells.
    Ghosh JC, Siegelin MD, Dohi T, Altieri DC., Free PMC Article

    04/9/2019
    adult viable human brain and liver mitochondria possess an active CypD-sensitive mitochondrial permeability transition

    Cyclophilin D-sensitive mitochondrial permeability transition in adult human brain and liver mitochondria.
    Hansson MJ, Morota S, Chen L, Matsuyama N, Suzuki Y, Nakajima S, Tanoue T, Omi A, Shibasaki F, Shimazu M, Ikeda Y, Uchino H, Elmér E., Free PMC Article

    04/9/2019
    Human coronavirus-induced neuronal programmed cell death required cyclophilin d but not caspase 3 caspase 9 activities.

    Human coronavirus-induced neuronal programmed cell death is cyclophilin d dependent and potentially caspase dispensable.
    Favreau DJ, Meessen-Pinard M, Desforges M, Talbot PJ., Free PMC Article

    04/9/2019
    CypD directs mitochondria-to-nuclei inflammatory gene expression in normal and tumor cells

    Cyclophilin D extramitochondrial signaling controls cell cycle progression and chemokine-directed cell motility.
    Tavecchio M, Lisanti S, Lam A, Ghosh JC, Martin NM, O'Connell M, Weeraratna AT, Kossenkov AV, Showe LC, Altieri DC., Free PMC Article

    04/9/2019
    These results suggest Cyp-D's critical role in UVB/oxidative stress-induced skin cell death.

    Ultra-violet B (UVB)-induced skin cell death occurs through a cyclophilin D intrinsic signaling pathway.
    Ji C, Yang B, Yang Z, Tu Y, Yang YL, He L, Bi ZG.

    04/9/2019
    cisplatin-induced non-apoptotic death requires mitochondria Cyp-D-p53 signaling in pancreatic cancer cells

    Cisplatin-induced non-apoptotic death of pancreatic cancer cells requires mitochondrial cyclophilin-D-p53 signaling.
    Chen B, Xu M, Zhang H, Wang JX, Zheng P, Gong L, Wu GJ, Dai T.

    04/9/2019
    The p53/Cyp-D mitochondrial complexation was prevented by CsA or Cyp-D silencing.

    The mitochondrial cyclophilin D/p53 complexation mediates doxorubicin-induced non-apoptotic death of A549 lung cancer cells.
    Lu JH, Shi ZF, Xu H.

    04/9/2019
    In summary, the results of the present study provide mechanistic evidence that both apoptosis and programmed necrosis attribute to berberine's cytotoxicity in prostate cancer cells.

    Mitochondrial protein cyclophilin-D-mediated programmed necrosis attributes to berberine-induced cytotoxicity in cultured prostate cancer cells.
    Zhang LY, Wu YL, Gao XH, Guo F.

    04/9/2019
    molecular determinants necessary for Cyclophilin D activity regulation and binding to proposed pore constituents thereby regulating the mitochondrial permeability transition pore.

    Structural mechanisms of cyclophilin D-dependent control of the mitochondrial permeability transition pore.
    Gutiérrez-Aguilar M, Baines CP., Free PMC Article

    04/9/2019
    Cyp-D silencing down-regulated mitochondrial transcripts initiated from the heavy strand promoter 2 [i.e., NADH dehydrogenase 1 (ND1) by 11-fold; cytochrome oxidase 1 (COX1) by 4-fold; and ATP synthase subunit 6 (ATP6) by 6.5-fold.

    Cyclophilin-D: a resident regulator of mitochondrial gene expression.
    Radhakrishnan J, Bazarek S, Chandran B, Gazmuri RJ.

    04/9/2019
    Results show that CypD interacts with SPG7 and VDAC to form the mitochondrial permeability transition pore complex (PTP)and its CsA-binding region is necessary for PTP formation.

    SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore.
    Shanmughapriya S, Rajan S, Hoffman NE, Higgins AM, Tomar D, Nemani N, Hines KJ, Smith DJ, Eguchi A, Vallem S, Shaikh F, Cheung M, Leonard NJ, Stolakis RS, Wolfers MP, Ibetti J, Chuprun JK, Jog NR, Houser SR, Koch WJ, Elrod JW, Madesh M., Free PMC Article

    04/9/2019
    The influx of unfolded p53 into the mitochondrial matrix in response to oxidative stress indirectly activates the normally inhibited CypD by displacing it from Trap1 complexes. This activates CypD's isomerase activity. Liberated CypD then isomerizes multiple proteins including p53 (causing p53 aggregation) and the structural components of the mPTP pore, inducing pore opening.

    A Novel In Vitro CypD-Mediated p53 Aggregation Assay Suggests a Model for Mitochondrial Permeability Transition by Chaperone Systems.
    Lebedev I, Nemajerova A, Foda ZH, Kornaj M, Tong M, Moll UM, Seeliger MA., Free PMC Article

    04/9/2019
    cyclophilin D may modify mitochondrial features by inducing the translocation of molecules to the mitochondria through the mechanism associated with cellular energy metabolism

    Long-term inhibition of cyclophilin D results in intracellular translocation of calcein AM from mitochondria to lysosomes.
    Shinohe D, Kobayashi A, Gotoh M, Tanaka K, Ohta Y.

    04/9/2019
    CyPD regulates mitochondrial metabolism, and likely cell survival, by promoting more efficient electrons flow through the respiratory chain via increased supercomplex formation

    Cyclophilin D over-expression increases mitochondrial complex III activity and accelerates supercomplex formation.
    Etzler JC, Bollo M, Holstein D, Deng JJ, Perez V, Lin DT, Richardson A, Bai Y, Lechleiter JD., Free PMC Article

    04/9/2019
    The present study is to investigate the role of CypD in regulating the mitochondrial dynamics relevant to oxidative stress induced neuron dysfunctions.

    The cyclophilin D/Drp1 axis regulates mitochondrial fission contributing to oxidative stress-induced mitochondrial dysfunctions in SH-SY5Y cells.
    Xiao A, Gan X, Chen R, Ren Y, Yu H, You C.

    04/9/2019
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