| Arp2/3 and Mena/VASP Require Profilin 1 for Actin Network Assembly at the Leading Edge. | Arp2/3 and Mena/VASP Require Profilin 1 for Actin Network Assembly at the Leading Edge.
Skruber K, Warp PV, Shklyarov R, Thomas JD, Swanson MS, Henty-Ridilla JL, Read TA, Vitriol EA., Free PMC Article | 08/21/2021 |
| Study provides evidence that the 5'-UTR1 of ARPC2 has internal ribosome entry site activity and regulates translation during stressful cellular conditions such as high cell density. | Alternatively spliced variants of the 5'-UTR of the ARPC2 mRNA regulate translation by an internal ribosome entry site (IRES) harboring a guanine-quadruplex motif.
Al-Zeer MA, Dutkiewicz M, von Hacht A, Kreuzmann D, Röhrs V, Kurreck J., Free PMC Article | 05/2/2020 |
| Results find that ARPC2 expression is upregulated in breast cancer tissues and cell lines. ARPC2 promotes the proliferation and metastasis of human breast cancer cells. ARPC2 is regulated by RBM2 in a posttranscriptional 3'UTRbinding manner. Also, ARPC2 plays an oncogenic role and mediates the promoting role of RBM3 in the proliferation and metastasis of human breast cancer cells. | RBM3 upregulates ARPC2 by binding the 3'UTR and contributes to breast cancer progression.
Chen P, Yue X, Xiong H, Lu X, Ji Z. | 08/17/2019 |
| These results collectively indicated that ARPC2 promoted the tumorigenesis of breast carcinoma and the initiation of epithelialmesenchymal transition. Therefore, ARPC2 was revealed to be a potential therapeutic target in patients with breast cancer (BrCa) . | ARPC2 promotes breast cancer proliferation and metastasis.
Cheng Z, Wei W, Wu Z, Wang J, Ding X, Sheng Y, Han Y, Wu Q., Free PMC Article | 08/17/2019 |
| Study shows that the T-cell-specific deletion of Arpc2 results in compromised peripheral T-cell homeostasis suggesting that ARPC2 is essential for T-cell homeostasis probably by maintaining surface TCR levels via regulating TCR(+) endosome trafficking. | Arp2/3 complex controls T cell homeostasis by maintaining surface TCR levels via regulating TCR(+) endosome trafficking.
Zhang Y, Shen H, Liu H, Feng H, Liu Y, Zhu X, Liu X., Free PMC Article | 04/6/2019 |
| In the association analysis of 110 gastric cancer tissues, ARPC2 showed significant associations with large tumor size, lymph node invasion, and high tumor stage. In addition, ARPC2-positive patients exhibited lower RFS and OS rates compared with ARPC2-negative patients. We thus identify that ARPC2 plays an aneretic role in human gastric cancer and provided a new target for gastric cancer therapy. | Role of ARPC2 in Human Gastric Cancer.
Zhang J, Liu Y, Yu CJ, Dai F, Xiong J, Li HJ, Wu ZS, Ding R, Wang H., Free PMC Article | 05/5/2018 |
| Downregulation of the ARP2/3 complex signaling pathway, a common final pathway for multiple signaling cascades that regulate the actin cytoskeleton, would compromise the structural stability of spines, leading to their loss. In concert with findings from deletion of the ARP2/3 complex in mice, these findings support the idea that spine deficits in the DLPFC may contribute to subcortical hyperdopaminergia in schizophrenia. | Altered Expression of ARP2/3 Complex Signaling Pathway Genes in Prefrontal Layer 3 Pyramidal Cells in Schizophrenia.
Datta D, Arion D, Roman KM, Volk DW, Lewis DA., Free PMC Article | 05/7/2017 |
| Recent reports now demonstrate a novel aspect of the ARP2/3 complex and the nucleating-promoting factors in the maintenance of endothelial barrier function and junction remodeling of established endothelial cell junctions. | Dynamics between actin and the VE-cadherin/catenin complex: novel aspects of the ARP2/3 complex in regulation of endothelial junctions.
Abu Taha A, Schnittler HJ., Free PMC Article | 05/30/2015 |
| FOXF1 repressed cell growth and expression of collagen-1 and actin-related protein 2/3 complex, subunit 2. | Forkhead Box F1 represses cell growth and inhibits COL1 and ARPC2 expression in lung fibroblasts in vitro.
Melboucy-Belkhir S, Pradère P, Tadbiri S, Habib S, Bacrot A, Brayer S, Mari B, Besnard V, Mailleux A, Guenther A, Castier Y, Mal H, Crestani B, Plantier L. | 03/7/2015 |
| The Arp2/3 complex is recruited to invading Rickettsia parkeri and is required for efficient invasion. | Rickettsia parkeri invasion of diverse host cells involves an Arp2/3 complex, WAVE complex and Rho-family GTPase-dependent pathway.
Reed SC, Serio AW, Welch MD., Free PMC Article | 06/30/2012 |
| Filopodia initiation: focus on the Arp2/3 complex and formins | Filopodia initiation: focus on the Arp2/3 complex and formins.
Yang C, Svitkina T., Free PMC Article | 01/28/2012 |
| Endogenous Nogo-B, which may exert its effects through ARPC 2/3 and MYL-9, is necessary for the migration and contraction of airway smooth muscle cells. | Nogo-B regulates migration and contraction of airway smooth muscle cells by decreasing ARPC 2/3 and increasing MYL-9 expression.
Xu W, Hong W, Shao Y, Ning Y, Cai Z, Li Q., Free PMC Article | 05/7/2011 |
| The results identify Arp2/3 complex as a key factor in the generation of the dynamic actin cluster during mitosis. | Revolving movement of a dynamic cluster of actin filaments during mitosis.
Mitsushima M, Aoki K, Ebisuya M, Matsumura S, Yamamoto T, Matsuda M, Toyoshima F, Nishida E., Free PMC Article | 12/11/2010 |
| WASH is a bimodular protein and a component of the BLOC-1 complex in which the C terminus is involved in Arp2/3-mediated actin nucleation, whereas the N-terminal portion is required for its regulation and localization in the cells | Functional characterization of Wiskott-Aldrich syndrome protein and scar homolog (WASH), a bi-modular nucleation-promoting factor able to interact with biogenesis of lysosome-related organelle subunit 2 (BLOS2) and gamma-tubulin.
Monfregola J, Napolitano G, D'Urso M, Lappalainen P, Ursini MV., Free PMC Article | 06/28/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk.
Festen EA, Stokkers PC, van Diemen CC, van Bodegraven AA, Boezen HM, Crusius BJ, Hommes DW, van der Woude CJ, Balschun T, Verspaget HW, Schreiber S, de Jong DJ, Franke A, Dijkstra G, Wijmenga C, Weersma RK. | 12/2/2009 |
| Compared with controls, actin-related protein 2/3 level was markedly increased in brains of intractable epilepsy patients. | Overexpression of N-WASP in the brain of human epilepsy.
Xiao F, Wang XF, Li JM, Xi ZQ, Lu Y, Wang L, Zeng Y, Guan LF, Yuan J. | 01/21/2010 |
| These findings strongly suggest that defective IL10 function is central to the pathogenesis of the ulcerative colitis subtype of inflammatory bowel disease. | Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility.
Franke A, Balschun T, Karlsen TH, Sventoraityte J, Nikolaus S, Mayr G, Domingues FS, Albrecht M, Nothnagel M, Ellinghaus D, Sina C, Onnie CM, Weersma RK, Stokkers PC, Wijmenga C, Gazouli M, Strachan D, McArdle WL, Vermeire S, Rutgeerts P, Rosenstiel P, Krawczak M, Vatn MH, IBSEN study group, Mathew CG, Schreiber S, Franke A, Balschun T, Karlsen TH, Sventoraityte J, Nikolaus S, Mayr G, Domingues FS, Albrecht M, Nothnagel M, Ellinghaus D, Sina C, Onnie CM, Weersma RK, Stokkers PC, Wijmenga C, Gazouli M, Strachan D, McArdle WL, Vermeire S, Rutgeerts P, Rosenstiel P, Krawczak M, Vatn MH, IBSEN study group, Mathew CG, Schreiber S. | 01/21/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility.
Franke A, Balschun T, Karlsen TH, Sventoraityte J, Nikolaus S, Mayr G, Domingues FS, Albrecht M, Nothnagel M, Ellinghaus D, Sina C, Onnie CM, Weersma RK, Stokkers PC, Wijmenga C, Gazouli M, Strachan D, McArdle WL, Vermeire S, Rutgeerts P, Rosenstiel P, Krawczak M, Vatn MH, IBSEN study group, Mathew CG, Schreiber S, Franke A, Balschun T, Karlsen TH, Sventoraityte J, Nikolaus S, Mayr G, Domingues FS, Albrecht M, Nothnagel M, Ellinghaus D, Sina C, Onnie CM, Weersma RK, Stokkers PC, Wijmenga C, Gazouli M, Strachan D, McArdle WL, Vermeire S, Rutgeerts P, Rosenstiel P, Krawczak M, Vatn MH, IBSEN study group, Mathew CG, Schreiber S. | 10/19/2008 |
| Arp2/3 complex genes have roles in actin organization and possibly in cancer phenotypes | Decreased expression of the seven ARP2/3 complex genes in human gastric cancers.
Kaneda A, Kaminishi M, Sugimura T, Ushijima T. | 01/21/2010 |
| The actin-related protein 2 accumulated in punctate structures that formed an extensivenetwork in a region corresponding to the postition of the Golgi complex. | Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics.
Dubois T, Paléotti O, Mironov AA, Fraisier V, Stradal TE, De Matteis MA, Franco M, Chavrier P. | 01/21/2010 |