| LRPPRC promotes glycolysis by stabilising LDHA mRNA and its knockdown plus glutamine inhibitor induces synthetic lethality via m[6] A modification in triple-negative breast cancer. | LRPPRC promotes glycolysis by stabilising LDHA mRNA and its knockdown plus glutamine inhibitor induces synthetic lethality via m(6) A modification in triple-negative breast cancer.
Yu Y, Deng H, Wang W, Xiao S, Zheng R, Lv L, Wang H, Chen J, Zhang B., Free PMC Article | 02/29/2024 |
| LRPPRC regulates malignant behaviors, protects mitochondrial homeostasis, mitochondrial function in osteosarcoma and derived cancer stem-like cells. | LRPPRC regulates malignant behaviors, protects mitochondrial homeostasis, mitochondrial function in osteosarcoma and derived cancer stem-like cells.
Zhao Z, Sun Y, Tang J, Yang Y, Xu X., Free PMC Article | 10/5/2023 |
| GREM1, LRPPRC and SLC39A4 as potential biomarkers of intervertebral disc degeneration: a bioinformatics analysis based on multiple microarray and single-cell sequencing data. | GREM1, LRPPRC and SLC39A4 as potential biomarkers of intervertebral disc degeneration: a bioinformatics analysis based on multiple microarray and single-cell sequencing data.
Zhang Z, Huo J, Ji X, Wei L, Zhang J., Free PMC Article | 09/18/2023 |
| LRPPRC facilitates tumor progression and immune evasion through upregulation of m[6]A modification of PD-L1 mRNA in hepatocellular carcinoma. | LRPPRC facilitates tumor progression and immune evasion through upregulation of m(6)A modification of PD-L1 mRNA in hepatocellular carcinoma.
Wang H, Tang A, Cui Y, Gong H, Li H., Free PMC Article | 04/19/2023 |
| Deubiquitylase PSMD14 inhibits autophagy to promote ovarian cancer progression via stabilization of LRPPRC. | Deubiquitylase PSMD14 inhibits autophagy to promote ovarian cancer progression via stabilization of LRPPRC.
Zhao Z, Xu H, Wei Y, Sun L, Song Y. | 01/11/2023 |
| LncRNA SNHG17 interacts with LRPPRC to stabilize c-Myc protein and promote G1/S transition and cell proliferation. | LncRNA SNHG17 interacts with LRPPRC to stabilize c-Myc protein and promote G1/S transition and cell proliferation.
Liu JY, Chen YJ, Feng HH, Chen ZL, Wang YL, Yang JE, Zhuang SM., Free PMC Article | 02/5/2022 |
| LRPPRC contributes to the cisplatin resistance of lung cancer cells by regulating MDR1 expression. | LRPPRC contributes to the cisplatin resistance of lung cancer cells by regulating MDR1 expression.
Hu Y, Cui J, Jin L, Su Y, Zhang X. | 10/30/2021 |
| Messenger RNA delivery to mitoribosomes - hints from a bacterial toxin. | Messenger RNA delivery to mitoribosomes - hints from a bacterial toxin.
Bruni F, Proctor-Kent Y, Lightowlers RN, Chrzanowska-Lightowlers ZM., Free PMC Article | 06/19/2021 |
| Alzheimer's and Parkinson's brain tissues have reduced expression of genes for mtDNA OXPHOS Proteins, mitobiogenesis regulator PGC-1alpha protein and mtRNA stabilizing protein LRPPRC (LRP130). | Alzheimer's and Parkinson's brain tissues have reduced expression of genes for mtDNA OXPHOS Proteins, mitobiogenesis regulator PGC-1α protein and mtRNA stabilizing protein LRPPRC (LRP130).
Bennett JP Jr, Keeney PM. | 04/3/2021 |
| Fiber-specific and whole-muscle LRP130 expression in rested, exercised, and fasted human skeletal muscle. | Fiber-specific and whole-muscle LRP130 expression in rested, exercised, and fasted human skeletal muscle.
Islam H, Ma A, Amato A, Cuillerier A, Burelle Y, Simpson CA, Quadrilatero J, Gurd BJ. | 02/2/2021 |
| LRPPRC sustains Yap-P27-mediated cell ploidy and P62-HDAC6-mediated autophagy maturation and suppresses genome instability and hepatocellular carcinomas. | LRPPRC sustains Yap-P27-mediated cell ploidy and P62-HDAC6-mediated autophagy maturation and suppresses genome instability and hepatocellular carcinomas.
Li W, Dai Y, Shi B, Yue F, Zou J, Xu G, Jiang X, Wang F, Zhou X, Liu L. | 11/28/2020 |
| Data demonstrate the importance of mTORC1, independent of the HIF-1alpha/PDHK1 axis, in maintaining LRPPRC and COX expression dermal fibroblasts from Leigh syndrome French Canadian type patients. | mTORC1 is required for expression of LRPPRC and cytochrome-c oxidase but not HIF-1α in Leigh syndrome French Canadian type patient fibroblasts.
Mukaneza Y, Cohen A, Rivard MÈ, Tardif J, Deschênes S, Ruiz M, LSFC Consortium, Laprise C, Des Rosiers C, Coderre L., Free PMC Article | 03/28/2020 |
| Knock-down of LRPPRC promotes apoptosis of hormone resistant prostate cancer cells. | [Knock-down of leucine-rich pentatricopeptide repeat containing(LRPPRC) promotes apoptosis of hormone resistant prostate cancer cells].
Zhang H, Xiao K, Zhao G, Li H, Cui J. | 09/7/2019 |
| Study demonstrated that the LRPPRC-SLIRP complex is a global RNA chaperone that stabilizes RNA structures to expose the required sites for translation, stabilization, and polyadenylation. | LRPPRC-mediated folding of the mitochondrial transcriptome.
Siira SJ, Spåhr H, Shearwood AJ, Ruzzenente B, Larsson NG, Rackham O, Filipovska A., Free PMC Article | 09/8/2018 |
| To investigate the impact of the OXPHOS defect in the liver, aothors analyzed the mitochondrial phenotype in mice harboring an hepatocyte-specific inactivation of Lrpprc. Loss of LRPPRC in the liver caused a generalized growth delay, and typical histological features of mitochondrial hepatopathy. | Loss of hepatic LRPPRC alters mitochondrial bioenergetics, regulation of permeability transition and trans-membrane ROS diffusion.
Cuillerier A, Honarmand S, Cadete VJJ, Ruiz M, Forest A, Deschênes S, Beauchamp C, LSFC Consortium, Charron G, Rioux JD, Des Rosiers C, Shoubridge EA, Burelle Y., Free PMC Article | 01/20/2018 |
| There were no significant correlations between LRP130, SIRT3, or PGC-1alpha mRNA expression in response to acute sprint-interval training. Changes in protein expression of LRP130, SIRT3, and PGC-1alpha were positively correlated at several time points with large effect sizes, which suggest that the regulation of these proteins may be coordinated in human skeletal muscle. | The effect of acute and chronic sprint-interval training on LRP130, SIRT3, and PGC-1α expression in human skeletal muscle.
Edgett BA, Bonafiglia JT, Baechler BL, Quadrilatero J, Gurd BJ., Free PMC Article | 10/28/2017 |
| LRPPRC displays a broad and strong RNA binding capacity in vitro in contrast to SLIRP that associates only weakly with RNA. | SLIRP stabilizes LRPPRC via an RRM-PPR protein interface.
Spåhr H, Rozanska A, Li X, Atanassov I, Lightowlers RN, Chrzanowska-Lightowlers ZM, Rackham O, Larsson NG., Free PMC Article | 06/10/2017 |
| High expression of ULK1 concomitant with high expression of LRPPRC may serve as useful markers for shorter biochemical progression (BCP)-free survival and overall survival in patients with metastatic prostate cancer (PCa) after androgen deprivation therapy (ADT). | Elevated levels of autophagy-related marker ULK1 and mitochondrion-associated autophagy inhibitor LRPPRC are associated with biochemical progression and overall survival after androgen deprivation therapy in patients with metastatic prostate cancer.
Zhang HY, Ma YD, Zhang Y, Cui J, Wang ZM. | 06/3/2017 |
| This is the first study to report hypermethylation of LRPPRC, RAB6C, and ZNF471 in squamous cell carcinoma of the tongue | Gene promoter-associated CpG island hypermethylation in squamous cell carcinoma of the tongue.
Bhat S, Kabekkodu SP, Jayaprakash C, Radhakrishnan R, Ray S, Satyamoorthy K. | 04/8/2017 |
| LRPPRC knock-down in mammalian cells leads to an imbalance between mitochondria-encoded and nuclear-encoded subunits of complex IV | The loss of LRPPRC function induces the mitochondrial unfolded protein response.
Köhler F, Müller-Rischart AK, Conradt B, Rolland SG., Free PMC Article | 07/16/2016 |
| study identifies LRPPRC as an important disease-causing gene in an early-onset, multisystem and neurological mitochondrial disease. | LRPPRC mutations cause early-onset multisystem mitochondrial disease outside of the French-Canadian population.
Oláhová M, Hardy SA, Hall J, Yarham JW, Haack TB, Wilson WC, Alston CL, He L, Aznauryan E, Brown RM, Brown GK, Morris AA, Mundy H, Broomfield A, Barbosa IA, Simpson MA, Deshpande C, Moeslinger D, Koch J, Stettner GM, Bonnen PE, Prokisch H, Lightowlers RN, McFarland R, Chrzanowska-Lightowlers ZM, Taylor RW., Free PMC Article | 05/7/2016 |
| LRPPRC levels were reduced in muscle cells and undetectable in liver from French Canadian Leigh Syndrome patients. | Tissue-specific responses to the LRPPRC founder mutation in French Canadian Leigh Syndrome.
Sasarman F, Nishimura T, Antonicka H, Weraarpachai W, Shoubridge EA, LSFC Consortium., Free PMC Article | 09/26/2015 |
| LRPPRC is a transcription factor related to ABCB1 expression and highlight the importance of epigenetic regulation in CML resistance. | ABCB1 regulation through LRPPRC is influenced by the methylation status of the GC -100 box in its promoter.
Corrêa S, Binato R, Du Rocher B, Ferreira G, Cappelletti P, Soares-Lima S, Pinto LF, Mencalha A, Abdelhay E., Free PMC Article | 07/25/2015 |
| Downregulation of LRPPRC expression resulted in the reduced expression of Bcl-2, upregulation of Bax, and cleaved caspase-9 and caspase-3. This induces apoptosis through the mitochondria-mediated pathway in PCa cells. | Downregulation of LRPPRC induces apoptosis in prostate cancer cells through the mitochondria-mediated pathway.
Zhou J, Zhang F, Hou X, Zhang N. | 07/25/2015 |
| LRPPRC functions as a checkpoint protein that prevents mitochondria from autophagy degradation and impact tumorigenesis. | Autophagy inhibitor LRPPRC suppresses mitophagy through interaction with mitophagy initiator Parkin.
Zou J, Yue F, Li W, Song K, Jiang X, Yi J, Liu L., Free PMC Article | 06/6/2015 |