| The ARFRP1-dependent Golgi scaffolding protein GOPC is required for insulin secretion from pancreatic beta-cells. | The ARFRP1-dependent Golgi scaffolding protein GOPC is required for insulin secretion from pancreatic β-cells.
Wilhelmi I, Grunwald S, Gimber N, Popp O, Dittmar G, Arumughan A, Wanker EE, Laeger T, Schmoranzer J, Daumke O, Schürmann A., Free PMC Article | 10/30/2021 |
| LncRNA ARFRP1 knockdown inhibits LPS-induced the injury of chondrocytes by regulation of NF-kappaB pathway through modulating miR-15a-5p/TLR4 axis. | LncRNA ARFRP1 knockdown inhibits LPS-induced the injury of chondrocytes by regulation of NF-κB pathway through modulating miR-15a-5p/TLR4 axis.
Zhang G, Zhang Q, Zhu J, Tang J, Nie M. | 09/22/2021 |
| The amphipathic helices of Arfrp1 and Arl14 are sufficient to determine subcellular localizations. | The amphipathic helices of Arfrp1 and Arl14 are sufficient to determine subcellular localizations.
Yang F, Li T, Peng Z, Liu Y, Guo Y., Free PMC Article | 05/8/2021 |
| The ARFRP1 is a master regulator of retrograde-carrier tethering to the trans-Golgi network (TGN). | ARFRP1 functions upstream of ARL1 and ARL5 to coordinate recruitment of distinct tethering factors to the trans-Golgi network.
Ishida M, Bonifacino JS., Free PMC Article | 05/16/2020 |
| lack of Arfrp1 increases the abundance of lipolysis-modulating enzymes TERA/VCP, FAF2 and Plin2 at LDs, which might decrease lipolysis and reduce availability of fatty acids for triglyceride synthesis and their release via chylomicrons. | The GTPase ARFRP1 affects lipid droplet protein composition and triglyceride release from intracellular storage of intestinal Caco-2 cells.
Werno MW, Wilhelmi I, Kuropka B, Ebert F, Freund C, Schürmann A. | 05/25/2019 |
| Results provide evidence that ARFRP1 is required for HCV propagation through its interaction with NS5A protein. Also, ARFRP1 is involved in the regulation of lipid droplet (LD) growth in HCV-infected cells and, recruits SNAP23 to sites in close proximity to LDs. | ADP-ribosylation Factor-related Protein 1 Interacts with NS5A and Regulates Hepatitis C Virus Propagation.
Lim YS, Ngo HT, Lee J, Son K, Park EM, Hwang SB., Free PMC Article | 05/5/2018 |
| ARFRP1 shifted from a predominantly cis-Golgi and endosome-to-trans-Golgi network localization to localizing both Golgi and non-Golgi vesicular structures in hNaa30-depleted cells. | Depletion of the human N-terminal acetyltransferase hNaa30 disrupts Golgi integrity and ARFRP1 localization.
Starheim KK, Kalvik TV, Bjørkøy G, Arnesen T., Free PMC Article | 01/20/2018 |
| One or more of 7 genes residing in a chromosome 20q13.3 CNV region appears to influence BMI. The strongest candidate is ARFRP1. | A Copy Number Variant on Chromosome 20q13.3 Implicated in Thinness and Severe Obesity.
Hasstedt SJ, Xin Y, Mao R, Lewis T, Adams TD, Hunt SC., Free PMC Article | 10/22/2016 |
| Propose that Arfrp1 exposes a binding site on AP-1 that recognizes the Vangl2 sorting motif for capture into a transport vesicle destined for the proximal surface of a polarized epithelial cell. | A novel GTP-binding protein-adaptor protein complex responsible for export of Vangl2 from the trans Golgi network.
Guo Y, Zanetti G, Schekman R., Free PMC Article | 04/16/2016 |
| The GTPase ARFRP1 controls the lipidation of chylomicrons in the Golgi of the intestinal epithelium. | The GTPase ARFRP1 controls the lipidation of chylomicrons in the Golgi of the intestinal epithelium.
Jaschke A, Chung B, Hesse D, Kluge R, Zahn C, Moser M, Petzke KJ, Brigelius-Flohé R, Puchkov D, Koepsell H, Heeren J, Joost HG, Schürmann A., Free PMC Article | 01/26/2013 |
| Results show that ARL1 and ARFRP1 regulate retrograde transport of Shiga toxin to the TGN and anterograde transport of VSVG from the TGN, respectively. | Differential effects of depletion of ARL1 and ARFRP1 on membrane trafficking between the trans-Golgi network and endosomes.
Nishimoto-Morita K, Shin HW, Mitsuhashi H, Kitamura M, Zhang Q, Johannes L, Nakayama K., Free PMC Article | 01/21/2010 |
| Data show that ADP-ribosylation factor-related protein 1 (ARFRP1) is associated mainly with the trans-Golgi compartment and the trans-Golgi network (TGN) and is an essential regulatory factor for targeting of golgin-97 and golgin-245 onto Golgi membranes. | Roles of ARFRP1 (ADP-ribosylation factor-related protein 1) in post-Golgi membrane trafficking.
Shin HW, Kobayashi H, Kitamura M, Waguri S, Suganuma T, Uchiyama Y, Nakayama K. | 01/21/2010 |
| These data suggest that lethality of Arfrp1 knockout embryos is due to a specific disruption of protein targeting, e.g., of ARL1 and Golgin-245, to the Golgi. | Knockout of Arfrp1 leads to disruption of ARF-like1 (ARL1) targeting to the trans-Golgi in mouse embryos and HeLa cells.
Zahn C, Hommel A, Lu L, Hong W, Walther DJ, Florian S, Joost HG, Schürmann A. | 01/21/2010 |