Adhesion G Protein-Coupled Receptor G2 Promotes Hepatocellular Carcinoma Progression and Serves as a Neutrophil-Related Prognostic Biomarker. | Adhesion G Protein-Coupled Receptor G2 Promotes Hepatocellular Carcinoma Progression and Serves as a Neutrophil-Related Prognostic Biomarker. Wu Q, Wang P, Peng Q, Kang Z, Deng Y, Li J, Chen Y, Li J, Ge F., Free PMC Article | 12/20/2023 |
A novel ADGRG2 truncating variant associated with X-linked obstructive azoospermia in a large Chinese pedigree. | A novel ADGRG2 truncating variant associated with X-linked obstructive azoospermia in a large Chinese pedigree. Lu Y, Xie Y, Li M, Zuo N, Ning S, Luo B, Ning M, Song J, Liang Y, Qin Y., | 07/25/2023 |
Structures of the ADGRG2-Gs complex in apo and ligand-bound forms. | Structures of the ADGRG2-G(s) complex in apo and ligand-bound forms. Lin H, Xiao P, Bu RQ, Guo S, Yang Z, Yuan D, Zhu ZL, Zhang CX, He QT, Zhang C, Ping YQ, Zhao RJ, Ma CS, Liu CH, Zhang XN, Jiang D, Huang S, Xi YT, Zhang DL, Xue CY, Yang BS, Li JY, Lin HC, Zeng XH, Zhao H, Xu WM, Yi F, Liu Z, Sun JP, Yu X. | 10/29/2022 |
Conserved residues in the extracellular loop 2 regulate Stachel-mediated activation of ADGRG2. | Conserved residues in the extracellular loop 2 regulate Stachel-mediated activation of ADGRG2. Gad AA, Azimzadeh P, Balenga N., Free PMC Article | 11/27/2021 |
Novel ADGRG2 truncating variants in patients with X-linked congenital absence of vas deferens. | Novel ADGRG2 truncating variants in patients with X-linked congenital absence of vas deferens. Pagin A, Bergougnoux A, Girodon E, Reboul MP, Willoquaux C, Kesteloot M, Raynal C, Bienvenu T, Humbert M, Lalau G, Bieth E. | 05/29/2021 |
A novel hemizygous loss-of-function mutation in ADGRG2 causes male infertility with congenital bilateral absence of the vas deferens. | A novel hemizygous loss-of-function mutation in ADGRG2 causes male infertility with congenital bilateral absence of the vas deferens. Wu H, Gao Y, Ma C, Shen Q, Wang J, Lv M, Liu C, Cheng H, Zhu F, Tian S, Elshewy N, Ni X, Tan Q, Xu X, Zhou P, Wei Z, Zhang F, He X, Cao Y., Free PMC Article | 02/6/2021 |
data suggest that GPCR64 N-terminal fragment not only shields the tethered agonist to prevent G protein signaling but also confers a conformation that inhibits the interaction with beta-arrestins and the consequent endocytosis and sustained signaling from endosomes | Spatial regulation of GPR64/ADGRG2 signaling by β-arrestins and GPCR kinases. Azimzadeh P, Talamantez-Lyburn SC, Chang KT, Inoue A, Balenga N., Free PMC Article | 05/9/2020 |
G-protein coupled receptor 64 (GPR64) levels are remarkably lower in endometrial carcinoma samples compared to control. Depletion of GPR64 reveals an increase of colony formation ability, cell proliferation, cell migration, and invasion activity in Ishikawa and HEC1A cells. The expression of Connexin 43 is reduced through activation of AMP-activated protein kinase in tumor cells with GPR64-deficiency. | G-protein coupled receptor 64 (GPR64) acts as a tumor suppressor in endometrial cancer. Ahn JI, Yoo JY, Kim TH, Kim YI, Broaddus RR, Ahn JY, Lim JM, Jeong JW., Free PMC Article | 01/11/2020 |
Study identified novel nonsense variant c.2440C > T(p.Arg814*) in X-linked gene ADGRG2 as cause of obstructive azoospermia in a large Pakistani family. | X-linked ADGRG2 mutation and obstructive azoospermia in a large Pakistani family. Khan MJ, Pollock N, Jiang H, Castro C, Nazli R, Ahmed J, Basit S, Rajkovic A, Yatsenko AN., Free PMC Article | 11/30/2019 |
The expression of GPR64 was increased in human endometrial stromal cells (hESCs) during in vitro decidualization. Interestingly, siRNA-mediated knockdown of GPR64 in hESCs remarkably reduced decidualization. These results suggest that Gpr64 has a crucial role in the decidualization of endometrial stromal cells. | G-protein coupled receptor 64 is required for decidualization of endometrial stromal cells. Yoo JY, Ahn JI, Kim TH, Yu S, Ahn JY, Lim JM, Jeong JW., Free PMC Article | 01/19/2019 |
identified two missense variants in two congenital bilateral absence of the vas deferens (CBAVD) patients (c.G1709A, p.C570Y; and c.A2968G, p.K990E); study did not find any potential pathogenic CFTR variants, implying the ADGRG2 variants are the genetic cause in these patients | Pathogenic role of ADGRG2 in CBAVD patients replicated in Chinese population. Yang B, Wang J, Zhang W, Pan H, Li T, Liu B, Li H, Wang B. | 07/14/2018 |
GPR64 is expressed on the cell surface of parathyroid cells, is overexpressed in parathyroid tumors, and physically interacts with the CaSR. | Orphan Adhesion GPCR GPR64/ADGRG2 Is Overexpressed in Parathyroid Tumors and Attenuates Calcium-Sensing Receptor-Mediated Signaling. Balenga N, Azimzadeh P, Hogue JA, Staats PN, Shi Y, Koh J, Dressman H, Olson JA Jr., Free PMC Article | 01/13/2018 |
study confirms the crucial role of ADGRG2 in human male fertility and brings new insight into congenital obstructive azoospermia pathogenesis; in men with CBAVD who are CFTR-negative, ADGRG2 testing could allow for appropriate genetic counseling with regard to the X-linked transmission of the molecular defect | Truncating Mutations in the Adhesion G Protein-Coupled Receptor G2 Gene ADGRG2 Cause an X-Linked Congenital Bilateral Absence of Vas Deferens. Patat O, Pagin A, Siegfried A, Mitchell V, Chassaing N, Faguer S, Monteil L, Gaston V, Bujan L, Courtade-Saïdi M, Marcelli F, Lalau G, Rigot JM, Mieusset R, Bieth E., Free PMC Article | 05/13/2017 |
Knockdown of ADGRG2 breast cancer cell lines resulted in a strong reduction in cell adhesion and subsequent cell migration which was associated with a selective reduction in RelB. | The adhesion G protein-coupled receptor G2 (ADGRG2/GPR64) constitutively activates SRE and NFκB and is involved in cell adhesion and migration. Peeters MC, Fokkelman M, Boogaard B, Egerod KL, van de Water B, IJzerman AP, Schwartz TW. | 09/24/2016 |