| circRNA_141539 can serve as an oncogenic factor in esophageal squamous cell carcinoma by sponging miR-4469 and activating CDK3 gene. | circRNA_141539 can serve as an oncogenic factor in esophageal squamous cell carcinoma by sponging miR-4469 and activating CDK3 gene.
Liu ZH, Yang SZ, Li WY, Dong SY, Zhou SY, Xu S., Free PMC Article | 07/31/2021 |
| These results suggest that miR-125a-3p can function as a novel tumor suppressor in ER(+) breast cancer by targeting CDK3, which may be a potential therapeutic approach for TamR breast cancer therapy | miR-125a-3p inhibits ERα transactivation and overrides tamoxifen resistance by targeting CDK3 in estrogen receptor-positive breast cancer.
Zheng L, Meng X, Li X, Zhang Y, Li C, Xiang C, Xing Y, Xia Y, Xi T. | 10/27/2018 |
| HuR facilitated lung cancer stemness dependent on CDK3 expression. miR-873 or miR-125a-3p level was negatively correlated with HuR and CDK3 expression levels in lung cancer tissues. HuR facilitates lung cancer stemness via regulating miR-873/CDK3 and miR-125a-3p/CDK3 axis. | HuR facilitates cancer stemness of lung cancer cells via regulating miR-873/CDK3 and miR-125a-3p/CDK3 axis.
Zhang Y, Yang L, Ling C, Heng W. | 09/1/2018 |
| ectopic expression of HuR promotes breast cancer cell proliferation and survival by directly binding to and stabilizing CDK3 mRNA. | HuR promotes breast cancer cell proliferation and survival via binding to CDK3 mRNA.
Zhang Z, Huang A, Zhang A, Zhou C. | 03/24/2018 |
| These results provided evidence supporting the oncogenic potential of NFAT3 and suggested that CDK3-mediated phosphorylation of NFAT3 has an important role in skin tumorigenesis. | Phosphorylation of NFAT3 by CDK3 induces cell transformation and promotes tumor growth in skin cancer.
Xiao T, Zhu JJ, Huang S, Peng C, He S, Du J, Hong R, Chen X, Bode AM, Jiang W, Dong Z, Zheng D., Free PMC Article | 09/16/2017 |
| The analysis of tumor and matched normal lung tissues indicates that miR-150 downregulation in lung tumors correlates with higher CDK3 levels. In addition, miR-150 transfection experiments with cancer-derived cell lines reveal that miR-150-mediated CDK3 suppression directly induces growth inhibition. | CDK3 is a major target of miR-150 in cell proliferation and anti-cancer effect.
Wang L, Xi Y, Sun C, Zhang F, Jiang H, He Q, Li D. | 08/12/2017 |
| High Cdk3-promoted epithelial-mesenchymal transition through activating AP-1 is involved in colorectal cancer metastasis. | Cdk3-promoted epithelial-mesenchymal transition through activating AP-1 is involved in colorectal cancer metastasis.
Lu J, Zhang ZL, Huang D, Tang N, Li Y, Peng Z, Lu C, Dong Z, Tang F., Free PMC Article | 12/24/2016 |
| Data indicate that microRNA miR-214 has tumor-suppressive activity in hepatocellular carcinoma (HCC) through inhibition of E2F2 transcription factor (E2F2), cyclin-dependent kinases CDK3 and CDK6. | miR-214/199a/199a* cluster levels predict poor survival in hepatocellular carcinoma through interference with cell-cycle regulators.
Wang P, Chen S, Fang H, Wu X, Chen D, Peng L, Gao Z, Xie C., Free PMC Article | 11/12/2016 |
| Mir-873 inhibits ESR1 activity and cell growth via targeting CDK3. | MiR-873 regulates ERα transcriptional activity and tamoxifen resistance via targeting CDK3 in breast cancer cells.
Cui J, Yang Y, Li H, Leng Y, Qian K, Huang Q, Zhang C, Lu Z, Chen J, Sun T, Wu R, Sun Y, Song H, Wei X, Jing P, Yang X, Zhang C. | 10/10/2015 |
| CDK3 is associated with the progression of NPC, and may be a potential biomarker for prediction of the prognosis of patients with NPC. | CDK3 expression and its clinical significance in human nasopharyngeal carcinoma.
Wang L, Hu HY, Lin YL, Zhao ZX, Tan L, Yu P, Wan HJ, Jin Z, Zheng D. | 01/10/2015 |
| The Walleye dermal sarcoma virus cyclin functions as a structural ortholog of cyclin C in spite of its limited amino acid sequence identity with C cyclins or with any known cyclins and activates Cdk8 and Cdk3. | The retroviral cyclin of walleye dermal sarcoma virus binds cyclin-dependent kinases 3 and 8.
Brewster CD, Birkenheuer CH, Vogt MB, Quackenbush SL, Rovnak J., Free PMC Article | 01/22/2011 |
| Expression level of cdk3 is higher in human cancer cell lines and glioblastoma tissue compared with normal brain tissue. cdk3 phosphorylates activating transcription factor 1 (ATF1)and enhances the transactivation and transcriptional activities of ATF1. | Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation.
Zheng D, Cho YY, Lau AT, Zhang J, Ma WY, Bode AM, Dong Z., Free PMC Article | 01/21/2010 |
| A non-cdk8-associated cellular pool of cyclin C combines with cdk3 to stimulate pRb phosphorylation at S807/811 during the G0/G1 transition, and this phosphorylation is required for cells to exit G0 efficiently. | Cyclin C/cdk3 promotes Rb-dependent G0 exit.
Ren S, Rollins BJ. | 01/21/2010 |