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    ADAM10 ADAM metallopeptidase domain 10 [ Homo sapiens (human) ]

    Gene ID: 102, updated on 11-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Direct interaction of platelet with tumor cell aggravates hepatocellular carcinoma metastasis by activating TLR4/ADAM10/CX3CL1 axis.

    Direct interaction of platelet with tumor cell aggravates hepatocellular carcinoma metastasis by activating TLR4/ADAM10/CX3CL1 axis.
    Gao JH, He AD, Liu LM, Zhou YJ, Guo YW, Lu M, Zeng XB, Gong X, Lu YJ, Liang HF, Zhang BX, Ma R, Zhang RY, Ming ZY.

    03/5/2024
    Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis.

    Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis.
    Drexhage LZ, Zhang S, Dupont M, Ragaller F, Sjule E, Cabezas-Caballero J, Deimel LP, Robertson H, Russell RA, Dushek O, Sezgin E, Karaji N, Sattentau QJ., Free PMC Article

    02/16/2024
    ADAM10 as a biomarker for Alzheimer's disease: A systematic review.

    ADAM10 as a biomarker for Alzheimer's disease: A systematic review.
    Oliveira Monteiro E Pereira de Almeida MP, Valle Pedroso R, Mantellatto Grigoli M, Vicente Silva T, Manzine PR, Cominetti MR.

    02/12/2024
    Proteolytic cleavage of amyloid precursor protein by ADAM10 promotes proliferation and migration via activating MAPKs pathway in tongue squamous cell carcinoma in vitro.

    Proteolytic cleavage of amyloid precursor protein by ADAM10 promotes proliferation and migration via activating MAPKs pathway in tongue squamous cell carcinoma in vitro.
    Hong Y, Wei Z, Wang Y.

    01/4/2024
    NCK1-AS1 promotes the proliferation, migration, invasion, and EMT of non-small cell lung cancer by regulating the miR-361-5p/ADAM10 axis.

    NCK1-AS1 promotes the proliferation, migration, invasion, and EMT of non-small cell lung cancer by regulating the miR-361-5p/ADAM10 axis.
    Wu B, Wang Z, Xu H, Chu X, Jiang Q.

    12/20/2023
    Tissue inhibitors of metalloproteinases (TIMPs) modulate platelet ADAM10 activity.

    Tissue inhibitors of metalloproteinases (TIMPs) modulate platelet ADAM10 activity.
    Lee CSM, Kaur A, Montague SJ, Hicks SM, Andrews RK, Gardiner EE.

    12/6/2023
    Characterizing the transmembrane domains of ADAM10 and BACE1 and the impact of membrane composition.

    Characterizing the transmembrane domains of ADAM10 and BACE1 and the impact of membrane composition.
    Abraham CB, Xu L, Pantelopulos GA, Straub JE.,

    11/22/2023
    AMPK boosts ADAM10 shedding activity in human aortic endothelial cells by promoting Rab14-dependent ADAM10 cell surface translocation.

    AMPK boosts ADAM10 shedding activity in human aortic endothelial cells by promoting Rab14-dependent ADAM10 cell surface translocation.
    Baek CH, Kim H, Moon SY, Yang WS.

    08/25/2023
    Structural basis for membrane-proximal proteolysis of substrates by ADAM10.

    Structural basis for membrane-proximal proteolysis of substrates by ADAM10.
    Lipper CH, Egan ED, Gabriel KH, Blacklow SC.,

    08/25/2023
    Combined proteomics and CRISPR-Cas9 screens in PDX identify ADAM10 as essential for leukemia in vivo.

    Combined proteomics and CRISPR‒Cas9 screens in PDX identify ADAM10 as essential for leukemia in vivo.
    Bahrami E, Schmid JP, Jurinovic V, Becker M, Wirth AK, Ludwig R, Kreissig S, Duque Angel TV, Amend D, Hunt K, Öllinger R, Rad R, Frenz JM, Solovey M, Ziemann F, Mann M, Vick B, Wichmann C, Herold T, Jayavelu AK, Jeremias I., Free PMC Article

    07/12/2023
    Elevated Expression of ADAM10 Induced by HPV E6 Influences the Prognosis of Cervical Cancer.

    Elevated Expression of ADAM10 Induced by HPV E6 Influences the Prognosis of Cervical Cancer.
    Guo X, Dou Y, Liu S, Du Y, Guo R, Yue Y, Xu Y, Liu X, Xu Y.

    06/3/2023
    ADAM10 and ADAM17, Major Regulators of Chronic Kidney Disease Induced Atherosclerosis?

    ADAM10 and ADAM17, Major Regulators of Chronic Kidney Disease Induced Atherosclerosis?
    Maas SL, Donners MMPC, van der Vorst EPC., Free PMC Article

    05/3/2023
    Potential impact of ADAM-10 genetic variants with the clinical features of oral squamous cell carcinoma.

    Potential impact of ADAM-10 genetic variants with the clinical features of oral squamous cell carcinoma.
    Chen YT, Lin CW, Chou YE, Su SC, Chang LC, Lee CY, Hsieh MJ, Yang SF., Free PMC Article

    04/19/2023
    ADAM10 Gene Variants in AD Patients and Their Relationship to CSF Protein Levels.

    ADAM10 Gene Variants in AD Patients and Their Relationship to CSF Protein Levels.
    Agüero-Rabes P, Pérez-Pérez J, Cremades-Jimeno L, García-Ayllón MS, Gea-González A, Sainz MJ, Mahillo-Fernández I, Téllez R, Cárdaba B, Sáez-Valero J, Gómez-Tortosa E., Free PMC Article

    04/15/2023
    Circular RNA circ_0114876 regulates osteoarthritis through upregulating ADAM10 via targeting miR-1227-3p.

    Circular RNA circ_0114876 regulates osteoarthritis through upregulating ADAM10 via targeting miR-1227-3p.
    Ou L, Huang W, Zhang T, Xu D, Kong D, Meng Y.

    03/16/2023
    Decreased expression of ADAM10 on monocytes is associated with chronic allograft dysfunction in kidney transplant recipients.

    Decreased expression of ADAM10 on monocytes is associated with chronic allograft dysfunction in kidney transplant recipients.
    Li Y, Bai Y, Zhang H, Li Y, Yan L, Wang X, Fan J, An Y, Wan Z, Hu S, Wang L, Shi Y.

    02/28/2023
    Elevated Expression of ADAM10 in Skeletal Muscle of Patients with Idiopathic Inflammatory Myopathies Could Be Responsible for FNDC5/Irisin Unbalance.

    Elevated Expression of ADAM10 in Skeletal Muscle of Patients with Idiopathic Inflammatory Myopathies Could Be Responsible for FNDC5/Irisin Unbalance.
    Zerlotin R, Fornaro M, Errede M, Pignataro P, Suriano C, Ruggieri M, Colucci S, Iannone F, Grano M, Colaianni G., Free PMC Article

    02/16/2023
    ADAM10 Gene Polymorphism and Its Relationship to Hepatocellular Carcinoma in Egyptian HCV Patients Receiving Direct-Acting Antiviral Therapies (DAAs).

    ADAM10 Gene Polymorphism and Its Relationship to Hepatocellular Carcinoma in Egyptian HCV Patients Receiving Direct-Acting Antiviral Therapies (DAAs).
    Ghanem S, El Gedawy G, Yehia S, Bedair H, Awad S, Abdel-Razek W, Elhelbawy M, El-Sabaawy D, Elfert AY., Free PMC Article

    02/4/2023
    MT1-MMP and ADAM10/17 exhibit a remarkable overlap of shedding properties.

    MT1-MMP and ADAM10/17 exhibit a remarkable overlap of shedding properties.
    Werny L, Grogro A, Bickenbach K, Bülck C, Armbrust F, Koudelka T, Pathak K, Scharfenberg F, Sammel M, Sheikhouny F, Tholey A, Linder S, Becker-Pauly C.

    01/14/2023
    ADAM10 mediates shedding of carbonic anhydrase IX ectodomain nonredundantly to ADAM17.

    ADAM10 mediates shedding of carbonic anhydrase IX ectodomain non‑redundantly to ADAM17.
    Zatovicova M, Kajanova I, Takacova M, Jelenska L, Sedlakova O, Labudova M, Pastorekova S., Free PMC Article

    12/31/2022
    ADAM10 and ADAM17-Novel Players in Retinoblastoma Carcinogenesis.

    ADAM10 and ADAM17-Novel Players in Retinoblastoma Carcinogenesis.
    Van Meenen D, Doege A, Alefeld E, Haase A, Beier M, Kiefer T, Biewald E, Metz K, Dräger O, Busch MA, Dünker N., Free PMC Article

    11/5/2022
    The importance of a disintegrin and metalloproteinase (ADAM)10 and ADAM17 in the pathogenesis of psoriasis.

    The importance of a disintegrin and metalloproteinase (ADAM)10 and ADAM17 in the pathogenesis of psoriasis.
    Gül C, Kilic S, Şehitoğlu MH.

    08/27/2022
    Role of ADAM10 and ADAM17 in the Regulation of Keratinocyte Adhesion in Pemphigus Vulgaris.

    Role of ADAM10 and ADAM17 in the Regulation of Keratinocyte Adhesion in Pemphigus Vulgaris.
    Kugelmann D, Anders M, Sigmund AM, Egu DT, Eichkorn RA, Yazdi AS, Sárdy M, Hertl M, Didona D, Hashimoto T, Waschke J., Free PMC Article

    07/30/2022
    The transmembrane domain of the amyloid precursor protein is required for antiamyloidogenic processing by alpha-secretase ADAM10.

    The transmembrane domain of the amyloid precursor protein is required for antiamyloidogenic processing by α-secretase ADAM10.
    Hitschler L, Lang T., Free PMC Article

    07/2/2022
    ADAM10 and ADAM17 promote SARS-CoV-2 cell entry and spike protein-mediated lung cell fusion.

    ADAM10 and ADAM17 promote SARS-CoV-2 cell entry and spike protein-mediated lung cell fusion.
    Jocher G, Grass V, Tschirner SK, Riepler L, Breimann S, Kaya T, Oelsner M, Hamad MS, Hofmann LI, Blobel CP, Schmidt-Weber CB, Gokce O, Jakwerth CA, Trimpert J, Kimpel J, Pichlmair A, Lichtenthaler SF., Free PMC Article

    06/11/2022
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