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    PATJ PATJ crumbs cell polarity complex component [ Homo sapiens (human) ]

    Gene ID: 10207, updated on 3-Nov-2024

    GeneRIFs: Gene References Into Functions

    Submit: New GeneRIFCorrection

    GeneRIFPubMed TitleDate
    MUC1 and Polarity Markers INADL and SCRIB Identify Salivary Ductal Cells.

    MUC1 and Polarity Markers INADL and SCRIB Identify Salivary Ductal Cells.
    Wu D, Chapela PJ, Barrows CML, Harrington DA, Carson DD, Witt RL, Mohyuddin NG, Pradhan-Bhatt S, Farach-Carson MC., Free PMC Article

    		07/9/2022
    Meta-analysis: Novel variants in PATJ (Pals1-associated tight junction) gene were associated with worse functional outcome at 3-month after stroke. The top variant was rs76221407 .

    PATJ Low Frequency Variants Are Associated With Worse Ischemic Stroke Functional Outcome.
    Mola-Caminal M, Carrera C, Soriano-Tárraga C, Giralt-Steinhauer E, Díaz-Navarro RM, Tur S, Jiménez C, Medina-Dols A, Cullell N, Torres-Aguila NP, Muiño E, Rodríguez-Campello A, Ois A, Cuadrado-Godia E, Vivanco-Hidalgo RM, Hernandez-Guillamon M, Solé M, Delgado P, Bustamante A, García-Berrocoso T, Mendióroz M, Castellanos M, Serena J, Martí-Fàbregas J, Segura T, Serrano-Heras G, Obach V, Ribó M, Molina CA, Alvarez-Sabín J, Palomeras E, Freijo M, Font MA, Rosand J, Rost NS, Gallego-Fabrega C, Lee JM, Heitsch L, Ibanez L, Cruchaga C, Phuah CL, Lemmens R, Thijs V, Lindgren A, Maguire J, Rannikmae K, Sudlow CL, Jern C, Stanne TM, Lorentzen E, Muñoz-Narbona L, Dávalos A, López-Cancio E, Worrall BB, Woo D, Kittner SJ, Mitchell BD, Montaner J, Roquer J, Krupinski J, Estivill X, Rabionet R, Vives-Bauzá C, Fernández-Cadenas I, Jiménez-Conde J., Free PMC Article

    		10/26/2019
    Results indicate a role for Yes associated protein (YAP), which is inhibited by the Hippo pathway, in the cytokinesis machinery during mitosis through interaction with the polarity protein PATJ.

    Cytokinesis involves a nontranscriptional function of the Hippo pathway effector YAP.
    Bui DA, Lee W, White AE, Harper JW, Schackmann RC, Overholtzer M, Selfors LM, Brugge JS., Free PMC Article

    		12/17/2016
    Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

    Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article

    		06/30/2010
    Signalling molecules and effectors can be integrated into a functional network by the scaffold organizer protein PATJ via its multiple PDZ domains.

    Pals-associated tight junction protein functionally links dopamine and angiotensin II to the regulation of sodium transport in renal epithelial cells.
    Chen Z, Leibiger I, Katz AI, Bertorello AM., Free PMC Article

    		01/21/2010
    Results suggest that signaling mediated by Pals1, which has a higher affinity for Patj than for MUPP1 and is involved in the activation of the Par6-aPKC complex, is of principal importance for the function of Patj in epithelial cells.

    Similar and distinct properties of MUPP1 and Patj, two homologous PDZ domain-containing tight-junction proteins.
    Adachi M, Hamazaki Y, Kobayashi Y, Itoh M, Tsukita S, Furuse M, Tsukita S., Free PMC Article

    		01/21/2010
    Data show taht channel-interacting PDZ protein, 'CIPP', interacts with proteins involved in cytoskeletal dynamics.

    Channel-interacting PDZ protein, 'CIPP', interacts with proteins involved in cytoskeletal dynamics.
    Alpi E, Landi E, Barilari M, Serresi M, Salvadori P, Bachi A, Dente L.

    		01/21/2010
    the directional migration of capillaries in the embryo is governed by the Amot:Patj/Mupp1:Syx signaling that controls local GTPase activity

    The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells.
    Ernkvist M, Luna Persson N, Audebert S, Lecine P, Sinha I, Liu M, Schlueter M, Horowitz A, Aase K, Weide T, Borg JP, Majumdar A, Holmgren L., Free PMC Article

    		01/21/2010
    Data show that PATJ regulates the spatial concentration of several tight junction components at the border between the apical and lateral domains in Caco-2 cells.

    PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cells.
    Michel D, Arsanto JP, Massey-Harroche D, Béclin C, Wijnholds J, Le Bivic A.

    		01/21/2010
    PATJ controls directional migration by regulating the localization of aPKC and Par3 to the leading edge of epithelial cells.

    PATJ regulates directional migration of mammalian epithelial cells.
    Shin K, Wang Q, Margolis B., Free PMC Article

    		01/21/2010
    We have identified the tight junction-associated multi-PDZ protein PATJ (PALS1-associated TJ protein) as a novel binding partner and degradation target of high-risk types 16 and 18 E6.

    PATJ, a tight junction-associated PDZ protein, is a novel degradation target of high-risk human papillomavirus E6 and the alternatively spliced isoform 18 E6.
    Storrs CH, Silverstein SJ., Free PMC Article

    		01/21/2010
    interaction with crumbs and localization to tight junctions in epithelial cells

    hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells.
    Lemmers C, Médina E, Delgrossi MH, Michel D, Arsanto JP, Le Bivic A.

    		01/21/2010
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