| [Study on the Role of RASGRP2 in Vascular Endothelial Cells]. |
| 11/7/2023 |
| RASGRP2 is a potential immune-related biomarker and regulates mitochondrial-dependent apoptosis in lung adenocarcinoma. |
| 03/1/2023 |
| Novel RASGRP2 variants in platelet function defects: Indian study. |
| 05/7/2022 |
| CalDAG-GEFI Deficiency in a Family with Symptomatic Heterozygous and Homozygous Carriers of a Likely Pathogenic Variant in RASGRP2. |
| 02/5/2022 |
| The Role of RASGRP2 in Vascular Endothelial Cells-A Mini Review. |
| 01/22/2022 |
| RasGRP2 inhibits glyceraldehyde-derived toxic advanced glycation end-products from inducing permeability in vascular endothelial cells. |
| 11/13/2021 |
| Mutations in RASGRP2 gene identified in patients misdiagnosed as Glanzmann thrombasthenia patients. |
| 10/16/2021 |
| A novel missense variant in the RASGRP2 gene in patients with moderate to severe bleeding disorder. |
| 02/13/2021 |
| RasGRP2 Structure, Function and Genetic Variants in Platelet Pathophysiology. |
| 11/21/2020 |
| RASGRP2 mutation is associated with bleeding disorders. |
| 04/25/2020 |
| RASGRP2 was identified to be involved in the pathogenesis of rheumatoid arthritis by promoting adhesion, migration and IL-6 production from fibroblast-like synoviocytes |
| 08/24/2019 |
| results indicate that CD38 promotes RasGRP2/Rap1-mediated CLL cell adhesion and migration by increasing intracellular Ca2+ levels. |
| 04/13/2019 |
| we here describe a novel mutation in RASGRP2 that affects both expression and function of CalDAG-GEFI and that causes impaired platelet adhesive function and significant bleeding in humans. |
| 08/11/2018 |
| Eleven cases with unexplained bleeding or platelet disorders harbored 11 different, previously unreported RASGRP2 variants that were biallelic and likely pathogenic. |
| 09/30/2017 |
| These patients are the first cases of a CalDAG-GEFI deficiency due to homozygous RASGRP2 mutations that are linked to defects in both leukocyte and platelet integrin activation. |
| 08/5/2017 |
| These studies identify RasGRP2 as a novel substrate of ERK1/2 and define a negative-feedback loop that regulates the BRaf-MEK-ERK signaling cascade. This negative-feedback loop determines the amplitude and duration of active ERK1/2. |
| 05/13/2017 |
| RasGRP2 is exceptional in that its C1 domain has very weak binding affinity (Kd = 2890 +/- 240 nm for [(3)H]phorbol 12,13-dibutyrate. We have identified four amino acid residues responsible for this lack of sensitivity. Replacing Asn(7), Ser(8), Ala(19), and Ile(21) with the corresponding residues from RasGRP1/3 (Thr(7), Tyr(8), Gly(19), and Leu(21), respectively) conferred potent binding affinity (Kd = 1.47 +/- 0.03 nm). |
| 12/17/2016 |
| Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding. |
| 09/6/2014 |
| phosphorylation of CalDAG-GEFI is a critical mechanism by which PKA controls Rap1b-dependent platelet aggregation |
| 03/22/2014 |
| RasGRP2 increases cell viability and cell-matrix adhesion through increased Ras expression and Rap1 activation, respectively, in endothelial cells. |
| 02/8/2014 |
| NIH3T3 cells were found nonpermissive to mtHSV but they became permissive following transformation with the Rasgrp2 gene. This effect was linked to the activation of the Ras-PKR signaling pathway. |
| 02/1/2014 |
| analyzed the 5'-flanking region of rasgrp2 gene by a luciferase assay, which revealed that not only a promoter but also silencer regions were present upstream of D1E, suggesting rasgrp2 expression is controlled by a combination of promotion and repression |
| 11/27/2010 |
| CalDAG-GEFI plays a role in inside-out signaling to alphaIIbbeta3 |
| 01/21/2010 |