| NDP52 SUMOylation contributes to low-dose X-rays-induced cardiac hypertrophy through PINK1/Parkin-mediated mitophagy via MUL1/SUMO2 signalling. | NDP52 SUMOylation contributes to low-dose X-rays-induced cardiac hypertrophy through PINK1/Parkin-mediated mitophagy via MUL1/SUMO2 signalling.
Gao A, Wang M, Tang X, Shi G, Hou K, Fang J, Zhou L, Zhou H, Jiang W, Li Y, Ouyang F. | 02/5/2024 |
| Crotonylated BEX2 interacts with NDP52 and enhances mitophagy to modulate chemotherapeutic agent-induced apoptosis in non-small-cell lung cancer cells. | Crotonylated BEX2 interacts with NDP52 and enhances mitophagy to modulate chemotherapeutic agent-induced apoptosis in non-small-cell lung cancer cells.
Mu N, Wang Y, Li X, Du Z, Wu Y, Su M, Wang Y, Sun X, Su L, Liu X., Free PMC Article | 10/10/2023 |
| NDP52 acts as a redox sensor in PINK1/Parkin-mediated mitophagy. | NDP52 acts as a redox sensor in PINK1/Parkin-mediated mitophagy.
Kataura T, Otten EG, Rabanal-Ruiz Y, Adriaenssens E, Urselli F, Scialo F, Fan L, Smith GR, Dawson WM, Chen X, Yue WW, Bronowska AK, Carroll B, Martens S, Lazarou M, Korolchuk VI., Free PMC Article | 03/6/2023 |
| Baicalein Activates Parkin-Dependent Mitophagy through NDP52 and OPTN. | Baicalein Activates Parkin-Dependent Mitophagy through NDP52 and OPTN.
Ke PY, Chang CW, Hsiao YC., Free PMC Article | 07/23/2022 |
| Characterization of a natural variant of human NDP52 and its functional consequences on mitophagy. | Characterization of a natural variant of human NDP52 and its functional consequences on mitophagy.
Di Rita A, Angelini DF, Maiorino T, Caputo V, Cascella R, Kumar M, Tiberti M, Lambrughi M, Wesch N, Löhr F, Dötsch V, Carinci M, D'Acunzo P, Chiurchiù V, Papaleo E, Rogov VV, Giardina E, Battistini L, Strappazzon F., Free PMC Article | 03/19/2022 |
| Crosstalk Between NDP52 and LUBAC in Innate Immune Responses, Cell Death, and Xenophagy. | Crosstalk Between NDP52 and LUBAC in Innate Immune Responses, Cell Death, and Xenophagy.
Miyashita H, Oikawa D, Terawaki S, Kabata D, Shintani A, Tokunaga F., Free PMC Article | 09/25/2021 |
| The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment. | The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment.
Shi X, Chang C, Yokom AL, Jensen LE, Hurley JH., Free PMC Article | 02/13/2021 |
| The CALCOCO2, but not SQSTM1, suppresses the antiviral type I interferon signaling by promoting autophagy-mediated degradation of the mitochondrial antiviral signaling (MAVS) protein. | CALCOCO2/NDP52 and SQSTM1/p62 differentially regulate coxsackievirus B3 propagation.
Mohamud Y, Qu J, Xue YC, Liu H, Deng H, Luo H., Free PMC Article | 10/3/2020 |
| The altered expression of NRBP2 and CALCOCO2 is associated with left ventricular dysfunction parameters in human dilated cardiomyopathy. | The altered expression of autophagy-related genes participates in heart failure: NRBP2 and CALCOCO2 are associated with left ventricular dysfunction parameters in human dilated cardiomyopathy.
Gil-Cayuela C, López A, Martínez-Dolz L, González-Juanatey JR, Lago F, Roselló-Lletí E, Rivera M, Portolés M., Free PMC Article | 01/18/2020 |
| The capability of NDP52 to induce mitophagy is dependent on its interaction with the FIP200/ULK1 complex, which is facilitated by TBK1. Ectopically tethering ULK1 to cargo bypasses the requirement for autophagy receptors and TBK1. | Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy.
Vargas JNS, Wang C, Bunker E, Hao L, Maric D, Schiavo G, Randow F, Youle RJ., Free PMC Article | 10/19/2019 |
| we show that, essential for anti-bacterial autophagy, the cargo receptor NDP52 forms a trimeric complex with FIP200 and SINTBAD/NAP1, which are subunits of the autophagy-initiating ULK and the TBK1 kinase complex, respectively. FIP200 and SINTBAD/NAP1 are each recruited independently to bacteria via NDP52, as revealed by selective point mutations in their respective binding sites | The Cargo Receptor NDP52 Initiates Selective Autophagy by Recruiting the ULK Complex to Cytosol-Invading Bacteria.
Ravenhill BJ, Boyle KB, von Muhlinen N, Ellison CJ, Masson GR, Otten EG, Foeglein A, Williams R, Randow F., Free PMC Article | 10/19/2019 |
| These results indicate that NDP52 and MTPAP form an autophagy receptor complex, which enhances autophagic elimination of damaged mitochondria. | NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy.
Furuya N, Kakuta S, Sumiyoshi K, Ando M, Nonaka R, Suzuki A, Kazuno S, Saiki S, Hattori N., Free PMC Article | 07/20/2019 |
| evaluated the currently known TBK1-mediated phosphorylation sites in the SKICH domains of NDP52 and TAX1BP1 on the basis of their interactions with NAP1 | Mechanistic insights into the interactions of NAP1 with the SKICH domains of NDP52 and TAX1BP1.
Fu T, Liu J, Wang Y, Xie X, Hu S, Pan L., Free PMC Article | 02/9/2019 |
| Studies suggest that the nature of the regulatory mechanism(s) that governs nuclear dot protein 52 (NDP52) engagement during autophagosome maturation remains to be determined [Review]. | Novel Insights into NDP52 Autophagy Receptor Functioning.
Viret C, Rozières A, Faure M. | 01/5/2019 |
| Backfolding of MVI regulates its ability to bind DNA and that a putative transcription co-activator NDP52 relieves the auto-inhibition of MVI to enable DNA binding. Additionally, we show that the MVI-NDP52 complex binds RNAPII, which is critical for transcription, and that depletion of NDP52 or MVI reduces steady-state mRNA levels. | NDP52 activates nuclear myosin VI to enhance RNA polymerase II transcription.
Fili N, Hari-Gupta Y, Dos Santos Á, Cook A, Poland S, Ameer-Beg SM, Parsons M, Toseland CP., Free PMC Article | 10/6/2018 |
| findings reveal a negative feedback loop of RLR signaling generated by Tetherin-MARCH8-MAVS-NDP52 axis and provide insights into a better understanding of the crosstalk between selective autophagy and optimal deactivation of type I IFN signaling. | Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells.
Jin S, Tian S, Luo M, Xie W, Liu T, Duan T, Wu Y, Cui J. | 10/28/2017 |
| The authors propose that Rab35-GTP is a critical regulator of autophagy through recruiting autophagy receptor NDP52. | Rab35 GTPase recruits NDP52 to autophagy targets.
Minowa-Nozawa A, Nozawa T, Okamoto-Furuta K, Kohda H, Nakagawa I., Free PMC Article | 09/30/2017 |
| The authors identify calcium-binding and coiled-coil domain 2 (CALCOCO2, also known as NDP52) as a binding partner of influenza A virus PB1-F2. | Influenza virus protein PB1-F2 interacts with CALCOCO2 (NDP52) to modulate innate immune response.
Leymarie O, Meyer L, Tafforeau L, Lotteau V, Costa BD, Delmas B, Chevalier C, Le Goffic R. | 07/22/2017 |
| Presence of the NDP52 rs2303015 minor variant increases the risk for spontaneous bacterial peritonitis in patients with alcoholic cirrhosis. | A variant in the nuclear dot protein 52kDa gene increases the risk for spontaneous bacterial peritonitis in patients with alcoholic liver cirrhosis.
Lutz P, Krämer B, Kaczmarek DJ, Hübner MP, Langhans B, Appenrodt B, Lammert F, Nattermann J, Hoerauf A, Strassburg CP, Spengler U, Nischalke HD. | 10/29/2016 |
| insight into how CALCOCO2 targets ubiquitin-decorated pathogens for autophagic degradations | Molecular basis of ubiquitin recognition by the autophagy receptor CALCOCO2.
Xie X, Li F, Wang Y, Wang Y, Lin Z, Cheng X, Liu J, Chen C, Pan L., Free PMC Article | 09/17/2016 |
| control retrotransposon insertion in the genome | Autophagy supports genomic stability by degrading retrotransposon RNA.
Guo H, Chitiprolu M, Gagnon D, Meng L, Perez-Iratxeta C, Lagace D, Gibbings D. | 01/16/2016 |
| These data show that NDP52 promotes the maturation of autophagosomes via its interaction with LC3A, LC3B, and/or GABARAPL2 through a distinct LC3-interacting region, and with MYOSIN VI. | Autophagy receptor NDP52 regulates pathogen-containing autophagosome maturation.
Verlhac P, Grégoire IP, Azocar O, Petkova DS, Baguet J, Viret C, Faure M. | 01/2/2016 |
| data support a model in which non-ND10 resident Sp100 acts as a negative regulator of polycomb repressive complex-2 (PRC2) recruitment, and suggest that KSHV may actively escape ND10 silencing mechanisms to promote establishment of latent chromatin. | Influence of ND10 components on epigenetic determinants of early KSHV latency establishment.
Günther T, Schreiner S, Dobner T, Tessmer U, Grundhoff A., Free PMC Article | 11/7/2015 |
| two receptors previously linked to xenophagy, NDP52 and optineurin, are the primary receptors for PINK1- and parkin-mediated mitophagy | The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy.
Lazarou M, Sliter DA, Kane LA, Sarraf SA, Wang C, Burman JL, Sideris DP, Fogel AI, Youle RJ., Free PMC Article | 09/26/2015 |
| the role of ORF75 in the antagonization of ND10-mediated intrinsic immunity | Kaposi's sarcoma associated herpesvirus tegument protein ORF75 is essential for viral lytic replication and plays a critical role in the antagonization of ND10-instituted intrinsic immunity.
Full F, Jungnickl D, Reuter N, Bogner E, Brulois K, Scholz B, Stürzl M, Myoung J, Jung JU, Stamminger T, Ensser A., Free PMC Article | 02/14/2015 |