| IRX5 suppresses osteogenic differentiation of hBMSCs by inhibiting protein synthesis. | IRX5 suppresses osteogenic differentiation of hBMSCs by inhibiting protein synthesis.
Jiang B, Zheng J, Yao H, Wang Y, Song F, Huang C. | 06/18/2024 |
| The Hematopoietic TALE-Code Shows Normal Activity of IRX1 in Myeloid Progenitors and Reveals Ectopic Expression of IRX3 and IRX5 in Acute Myeloid Leukemia. | The Hematopoietic TALE-Code Shows Normal Activity of IRX1 in Myeloid Progenitors and Reveals Ectopic Expression of IRX3 and IRX5 in Acute Myeloid Leukemia.
Nagel S, Pommerenke C, Meyer C, MacLeod RAF., Free PMC Article | 04/16/2022 |
| A duplication on chromosome 16q12 affecting the IRXB gene cluster is associated with autosomal dominant cone dystrophy with early tritanopic color vision defect. | A duplication on chromosome 16q12 affecting the IRXB gene cluster is associated with autosomal dominant cone dystrophy with early tritanopic color vision defect.
Kohl S, Llavona P, Sauer A, Reuter P, Weisschuh N, Kempf M, Dehmelt FA, Arrenberg AB, Sliesoraityte I, Zrenner E, van Schooneveld MJ, Rudolph G, Kühlewein L, Wissinger B., Free PMC Article | 04/2/2022 |
| Human model of IRX5 mutations reveals key role for this transcription factor in ventricular conduction. | Human model of IRX5 mutations reveals key role for this transcription factor in ventricular conduction.
Al Sayed ZR, Canac R, Cimarosti B, Bonnard C, Gourraud JB, Hamamy H, Kayserili H, Girardeau A, Jouni M, Jacob N, Gaignerie A, Chariau C, David L, Forest V, Marionneau C, Charpentier F, Loussouarn G, Lamirault G, Reversade B, Zibara K, Lemarchand P, Gaborit N. | 02/12/2022 |
| IRX5 prompts genomic instability in colorectal cancer cells. | IRX5 prompts genomic instability in colorectal cancer cells.
Sun X, Jiang X, Wu J, Ma R, Wu Y, Cao H, Wang Z, Liu S, Zhang J, Wu Y, Zhang Y, Feng J, Wang T. | 08/7/2021 |
| Iroquois Homeobox 5 Negatively Regulated by miRNA-147 Promotes the Proliferation, Metastasis, and Invasion by Oral Squamous Cell Carcinoma. | Iroquois Homeobox 5 Negatively Regulated by miRNA-147 Promotes the Proliferation, Metastasis, and Invasion by Oral Squamous Cell Carcinoma.
Zhu Z, Gong J, Kong J, Qian Y, Lu K, Wang H, Yu M. | 07/17/2021 |
| Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5. | Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5.
Sobreira DR, Joslin AC, Zhang Q, Williamson I, Hansen GT, Farris KM, Sakabe NJ, Sinnott-Armstrong N, Bozek G, Jensen-Cody SO, Flippo KH, Ober C, Bickmore WA, Potthoff M, Chen M, Claussnitzer M, Aneas I, Nóbrega MA., Free PMC Article | 06/19/2021 |
| Primary preadipocytes from carriers of the obesity risk allele rs1421085, in which expression of IRX3 and IRX5 is increased, displayed excessive accumulation of triglycerides, reduced mitochondrial oxidative capacity, reduced white adipocyte browning, and reduced thermogenesis relative to primary preadipocytes from nonrisk allele carriers. | FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.
Claussnitzer M, Dankel SN, Kim KH, Quon G, Meuleman W, Haugen C, Glunk V, Sousa IS, Beaudry JL, Puviindran V, Abdennur NA, Liu J, Svensson PA, Hsu YH, Drucker DJ, Mellgren G, Hui CC, Hauner H, Kellis M, Claussnitzer M, Dankel SN, Kim KH, Quon G, Meuleman W, Haugen C, Glunk V, Sousa IS, Beaudry JL, Puviindran V, Abdennur NA, Liu J, Svensson PA, Hsu YH, Drucker DJ, Mellgren G, Hui CC, Hauner H, Kellis M., Free PMC Articles: PMC4959911, PMC4959911 | 06/14/2021 |
| Genome editing in primary preadipocytes to create the obesity risk allele of rs1421085 caused increased expression of IRX3 and IRX5 during early adipocyte differentiation by disrupting a binding site for the ARID5B repressor. | FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.
Claussnitzer M, Dankel SN, Kim KH, Quon G, Meuleman W, Haugen C, Glunk V, Sousa IS, Beaudry JL, Puviindran V, Abdennur NA, Liu J, Svensson PA, Hsu YH, Drucker DJ, Mellgren G, Hui CC, Hauner H, Kellis M, Claussnitzer M, Dankel SN, Kim KH, Quon G, Meuleman W, Haugen C, Glunk V, Sousa IS, Beaudry JL, Puviindran V, Abdennur NA, Liu J, Svensson PA, Hsu YH, Drucker DJ, Mellgren G, Hui CC, Hauner H, Kellis M., Free PMC Articles: PMC4959911, PMC4959911 | 06/14/2021 |
| Transcription factorIRX5 promotes hepatocellular carcinoma proliferation and inhibits apoptosis by regulating the p53 signalling pathway. | Transcription factorIRX5 promotes hepatocellular carcinoma proliferation and inhibits apoptosis by regulating the p53 signalling pathway.
Zhu L, Dai L, Yang N, Liu M, Ma S, Li C, Shen J, Lin T, Wang D, Pan W, Li X., Free PMC Article | 05/22/2021 |
| our findings suggested that IRX5 promoted CRC metastasis by inhibiting the RHOA-ROCK1-LIMK1 axis, which correlates with a poor prognosis | IRX5 promotes colorectal cancer metastasis by negatively regulating the core components of the RHOA pathway.
Zhu Q, Wu Y, Yang M, Wang Z, Zhang H, Jiang X, Chen M, Jin T, Wang T. | 01/25/2020 |
| Promotion of IRX3 signalling or inhibition of IRX5 signalling could be a route towards differentiation therapy for Wilms tumour, in which WNT5A is a candidate molecule for enforced tubular maturation. | The Iroquois homeobox proteins IRX3 and IRX5 have distinct roles in Wilms tumour development and human nephrogenesis.
Holmquist Mengelbier L, Lindell-Munther S, Yasui H, Jansson C, Esfandyari J, Karlsson J, Lau K, Hui CC, Bexell D, Hopyan S, Gisselsson D., Free PMC Article | 12/21/2019 |
| Authors identify a novel association that implicates the IRX5 gene region in obesity and compare our results with previously derived interaction data for the region. | Complete re-sequencing of a 2Mb topological domain encompassing the FTO/IRXB genes identifies a novel obesity-associated region upstream of IRX5.
Hunt LE, Noyvert B, Bhaw-Rosun L, Sesay AK, Paternoster L, Nohr EA, Davey Smith G, Tommerup N, Sørensen TI, Elgar G., Free PMC Article | 10/8/2016 |
| Our findings suggest that IRX proteins integrate combinatorial transcriptional inputs to regulate key signaling molecules involved in the ontogeny of multiple organs during embryogenesis and homeostasis. | Mutations in IRX5 impair craniofacial development and germ cell migration via SDF1.
Bonnard C, Strobl AC, Shboul M, Lee H, Merriman B, Nelson SF, Ababneh OH, Uz E, Güran T, Kayserili H, Hamamy H, Reversade B. | 08/4/2012 |
| Irx5 is involved in the regulation of both the cell cycle and apoptosis in human prostate cancer cells | The iroquois homeobox gene 5 is regulated by 1,25-dihydroxyvitamin D3 in human prostate cancer and regulates apoptosis and the cell cycle in LNCaP prostate cancer cells.
Myrthue A, Rademacher BL, Pittsenbarger J, Kutyba-Brooks B, Gantner M, Qian DZ, Beer TM. | 01/21/2010 |
| involved in transcriptional regulation of heart morphogenesis | [Irx5: a transcription factor that regulates the cardiac repolarization gradient].
Bruneau BG. | 01/21/2010 |