| Single-molecule imaging reveals a direct role of CTCF's zinc fingers in SA interaction and cluster-dependent RNA recruitment. | Single-molecule imaging reveals a direct role of CTCF's zinc fingers in SA interaction and cluster-dependent RNA recruitment.
Huber J, Tanasie NL, Zernia S, Stigler J., Free PMC Article | 06/24/2024 |
| Different NIPBL requirements of cohesin-STAG1 and cohesin-STAG2. | Different NIPBL requirements of cohesin-STAG1 and cohesin-STAG2.
Alonso-Gil D, Cuadrado A, Giménez-Llorente D, Rodríguez-Corsino M, Losada A., Free PMC Article | 10/26/2023 |
| Potential role of STAG1 mutations in genetic predisposition to childhood hematological malignancies. | Potential role of STAG1 mutations in genetic predisposition to childhood hematological malignancies.
Saitta C, Rebellato S, Bettini LR, Giudici G, Panini N, Erba E, Massa V, Auer F, Friedrich U, Hauer J, Biondi A, Fazio G, Cazzaniga G., Free PMC Article | 08/27/2022 |
| PD-L1 regulates genomic stability via interaction with cohesin-SA1 in the nucleus. | PD-L1 regulates genomic stability via interaction with cohesin-SA1 in the nucleus.
Zhang W, Jin J, Wang Y, Fang L, Min L, Wang X, Ding L, Weng L, Xiao T, Zhou T, Wang P., Free PMC Article | 03/5/2022 |
| STAG2 loss-of-function affects short-range genomic contacts and modulates the basal-luminal transcriptional program of bladder cancer cells. | STAG2 loss-of-function affects short-range genomic contacts and modulates the basal-luminal transcriptional program of bladder cancer cells.
Richart L, Lapi E, Pancaldi V, Cuenca-Ardura M, Pau EC, Madrid-Mencía M, Neyret-Kahn H, Radvanyi F, Rodríguez JA, Cuartero Y, Serra F, Le Dily F, Valencia A, Marti-Renom MA, Real FX., Free PMC Article | 12/25/2021 |
| STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers. | STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers.
van der Lelij P, Newman JA, Lieb S, Jude J, Katis V, Hoffmann T, Hinterndorfer M, Bader G, Kraut N, Pearson MA, Peters JM, Zuber J, Gileadi O, Petronczki M., Free PMC Article | 07/10/2021 |
| Specialized functions of cohesins STAG1 and STAG2 in 3D genome architecture. | Specialized functions of cohesins STAG1 and STAG2 in 3D genome architecture.
Cuadrado A, Losada A. | 06/19/2021 |
| Whole Exome Sequencing Identifies Cohesin Component STAG1 Mutation in de novo Acute Myeloid Leukemia (FAB M2): A Pilot Study with Cytogenetics, Clinical and Prognostic Implications. | Whole Exome Sequencing Identifies Cohesin Component STAG1 Mutation in de novo Acute Myeloid Leukemia (FAB M2): A Pilot Study with Cytogenetics, Clinical and Prognostic Implications.
Sakthivel KM, Geetha N, Raj TVA, Chandran RK, Krishna KMNJ, Sreedharan H. | 03/6/2021 |
| Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation. | Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation.
Viny AD, Bowman RL, Liu Y, Lavallée VP, Eisman SE, Xiao W, Durham BH, Navitski A, Park J, Braunstein S, Alija B, Karzai A, Csete IS, Witkin M, Azizi E, Baslan T, Ott CJ, Pe'er D, Dekker J, Koche R, Levine RL., Free PMC Article | 09/12/2020 |
| Study provides a comprehensive review of the function of STAG1/2 in human physiology and disease and an integrative analysis of available omics data on STAG alterations in a wide array of cancers, comprising 53 691 patients and 1067 cell lines. | STAG Mutations in Cancer.
Romero-Pérez L, Surdez D, Brunet E, Delattre O, Grünewald TGP. | 08/1/2020 |
| We uncovered the cohesion subunit SA1 as a putative synthetic-essential target in cancers carrying inactivating mutations of its paralog, SA2. In SA2-deficient Ewing sarcoma and bladder cancer, further depletion of SA1 profoundly and specifically suppressed cancer cell proliferation, survival, and tumorigenic potential. | Somatic mutation of the cohesin complex subunit confers therapeutic vulnerabilities in cancer.
Liu Y, Xu H, Van der Jeught K, Li Y, Liu S, Zhang L, Fang Y, Zhang X, Radovich M, Schneider BP, He X, Huang C, Zhang C, Wan J, Ji G, Lu X., Free PMC Article | 09/21/2019 |
| The SNP but not wild-type had profound alterations in SA-1 expression with miR-29b inhibitor. | Single Nucleotide Polymorphism Facilitated Down-Regulation of the Cohesin Stromal Antigen-1: Implications for Colorectal Cancer Racial Disparities.
Datta S, Sherva RM, De La Cruz M, Long MT, Roy P, Backman V, Chowdhury S, Roy HK., Free PMC Article | 12/1/2018 |
| Here the authors demonstrate that the most frequently mutated subunit of the cohesin complex, STAG2, displays a strong synthetic lethal interaction with its paralog STAG1. Mechanistically, STAG1 loss abrogates sister chromatid cohesion in STAG2 mutated but not in wild-type cells leading to mitotic catastrophe, defective cell division and apoptosis. | Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts.
van der Lelij P, Lieb S, Jude J, Wutz G, Santos CP, Falkenberg K, Schlattl A, Ban J, Schwentner R, Hoffmann T, Kovar H, Real FX, Waldman T, Pearson MA, Kraut N, Peters JM, Zuber J, Petronczki M., Free PMC Article | 04/7/2018 |
| This first series reporting the phenotype ascribed to mutation in STAG1 highlights the importance of data sharing in the field of rare disorders. | STAG1 mutations cause a novel cohesinopathy characterised by unspecific syndromic intellectual disability.
Lehalle D, Mosca-Boidron AL, Begtrup A, Boute-Benejean O, Charles P, Cho MT, Clarkson A, Devinsky O, Duffourd Y, Duplomb-Jego L, Gérard B, Jacquette A, Kuentz P, Masurel-Paulet A, McDougall C, Moutton S, Olivié H, Park SM, Rauch A, Revencu N, Rivière JB, Rubin K, Simonic I, Shears DJ, Smol T, Taylor Tavares AL, Terhal P, Thevenon J, Van Gassen K, Vincent-Delorme C, Willemsen MH, Wilson GN, Zackai E, Zweier C, Callier P, Thauvin-Robinet C, Faivre L. | 03/31/2018 |
| Data indicate that cohesin subunit SA-1 (STAG1) is a promising therapeutic target in cancers with inactivating alterations of cohesin subunit SA-2 (STAG2). | Synthetic lethal interaction between the tumour suppressor STAG2 and its paralog STAG1.
Benedetti L, Cereda M, Monteverde L, Desai N, Ciccarelli FD., Free PMC Article | 03/24/2018 |
| There is LOH at STAG1 and STAG2 loci in oral squamous cell carcinoma (OSCC), but OSCC and NM showed similar transcriptional levels of STAG1, STAG2, and PDS5B. | Cohesin subunits, STAG1 and STAG2, and cohesin regulatory factor, PDS5b, in oral squamous cells carcinomas.
França JA, Diniz MG, Bernardes VF, Costa-Silva RC, Souza RP, Gomez RS, Gomes CC. | 02/17/2018 |
| Data support the hypothesis that CTCF and cohesin SA-1 have multiple roles in the regulation of gene expression during erythropoiesis. | CTCF and CohesinSA-1 Mark Active Promoters and Boundaries of Repressive Chromatin Domains in Primary Human Erythroid Cells.
Steiner LA, Schulz V, Makismova Y, Lezon-Geyda K, Gallagher PG., Free PMC Article | 07/22/2017 |
| TRF1 tethers SA1 within telomeric regions that SA1 transiently interacts with. SA1 and TRF1 together form longer DNA-DNA pairing tracts than with TRF1 alone, as revealed by atomic force microscopy imaging | Functional interplay between SA1 and TRF1 in telomeric DNA binding and DNA-DNA pairing.
Lin J, Countryman P, Chen H, Pan H, Fan Y, Jiang Y, Kaur P, Miao W, Gurgel G, You C, Piehler J, Kad NM, Riehn R, Opresko PL, Smith S, Tao YJ, Wang H., Free PMC Article | 06/24/2017 |
| Nuclear import and export signals of human cohesins SA1/STAG1 and SA2/STAG2 expressed in Saccharomyces cerevisiae. | Nuclear import and export signals of human cohesins SA1/STAG1 and SA2/STAG2 expressed in Saccharomyces cerevisiae.
Tarnowski LJ, Kowalec P, Milewski M, Jurek M, Plochocka D, Fronk J, Kurlandzka A., Free PMC Article | 02/14/2015 |
| Mutations in STAG1 is associated with acute myeloid leukemia. | Mutations in the cohesin complex in acute myeloid leukemia: clinical and prognostic implications.
Thol F, Bollin R, Gehlhaar M, Walter C, Dugas M, Suchanek KJ, Kirchner A, Huang L, Chaturvedi A, Wichmann M, Wiehlmann L, Shahswar R, Damm F, Göhring G, Schlegelberger B, Schlenk R, Döhner K, Döhner H, Krauter J, Ganser A, Heuser M. | 04/5/2014 |
| cohesin-SA1 and cohesin-SA2 participate in the DNA damage response | Distinct functions of human cohesin-SA1 and cohesin-SA2 in double-strand break repair.
Kong X, Ball AR Jr, Pham HX, Zeng W, Chen HY, Schmiesing JA, Kim JS, Berns M, Yokomori K., Free PMC Article | 03/22/2014 |
| Rad21 binds to SA proteins through two SA-binding motifs on Rad21. | Characterization of the interaction between the cohesin subunits Rad21 and SA1/2.
Zhang N, Jiang Y, Mao Q, Demeler B, Tao YJ, Pati D., Free PMC Article | 02/22/2014 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.
Chasman DI, Paré G, Mora S, Hopewell JC, Peloso G, Clarke R, Cupples LA, Hamsten A, Kathiresan S, Mälarstig A, Ordovas JM, Ripatti S, Parker AN, Miletich JP, Ridker PM., Free PMC Article | 01/20/2010 |
| cohesin(SA1) and cohesin(SA2) are differentially required for telomere and centromere cohesion, respectively. | Differential regulation of telomere and centromere cohesion by the Scc3 homologues SA1 and SA2, respectively, in human cells.
Canudas S, Smith S., Free PMC Article | 01/21/2010 |
| STAG1 (Scc3/SA1) subunit of cohesin interacts with the CCTC-binding factor CTCF bound to the c-myc insulator element. | CTCF physically links cohesin to chromatin.
Rubio ED, Reiss DJ, Welcsh PL, Disteche CM, Filippova GN, Baliga NS, Aebersold R, Ranish JA, Krumm A., Free PMC Article | 01/21/2010 |