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    CDKN1C cyclin dependent kinase inhibitor 1C [ Homo sapiens (human) ]

    Gene ID: 1028, updated on 17-Jun-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Promoter methylation and enhanced SKP2 are associated with the downregulation of CDKN1C in cervical squamous cell carcinoma.

    Promoter methylation and enhanced SKP2 are associated with the downregulation of CDKN1C in cervical squamous cell carcinoma.
    Roychowdhury A, Pal D, Basu M, Samadder S, Mondal R, Roy A, Roychoudhury S, Panda CK.

    05/17/2024
    MYOD-SKP2 axis boosts tumorigenesis in fusion negative rhabdomyosarcoma by preventing differentiation through p57[Kip2] targeting.

    MYOD-SKP2 axis boosts tumorigenesis in fusion negative rhabdomyosarcoma by preventing differentiation through p57(Kip2) targeting.
    Pomella S, Cassandri M, D'Archivio L, Porrazzo A, Cossetti C, Phelps D, Perrone C, Pezzella M, Cardinale A, Wachtel M, Aloisi S, Milewski D, Colletti M, Sreenivas P, Walters ZS, Barillari G, Di Giannatale A, Milano GM, De Stefanis C, Alaggio R, Rodriguez-Rodriguez S, Carlesso N, Vakoc CR, Velardi E, Schafer BW, Guccione E, Gatz SA, Wasti A, Yohe M, Ignatius M, Quintarelli C, Shipley J, Miele L, Khan J, Houghton PJ, Marampon F, Gryder BE, De Angelis B, Locatelli F, Rota R., Free PMC Article

    01/31/2024
    Structure-Function Analysis of p57KIP2 in the Human Pancreatic Beta Cell Reveals a Bipartite Nuclear Localization Signal.

    Structure-Function Analysis of p57KIP2 in the Human Pancreatic Beta Cell Reveals a Bipartite Nuclear Localization Signal.
    Choleva L, Wang P, Liu H, Wood O, Lambertini L, Scott DK, Karakose E, Stewart AF.

    01/11/2024
    Exploiting the fibroblast growth factor receptor-1 vulnerability to therapeutically restrict the MYC-EZH2-CDKN1C axis-driven proliferation in Mantle cell lymphoma.

    Exploiting the fibroblast growth factor receptor-1 vulnerability to therapeutically restrict the MYC-EZH2-CDKN1C axis-driven proliferation in Mantle cell lymphoma.
    Sircar A, Singh S, Xu-Monette ZY, Coyle KM, Hilton LK, Chavdoula E, Ranganathan P, Jain N, Hanel W, Tsichlis P, Alinari L, Peterson BR, Tao J, Muthusamy N, Baiocchi R, Epperla N, Young KH, Morin R, Sehgal L., Free PMC Article

    10/11/2023
    PIK3R3 is upregulated in liver cancer and activates Akt signaling to control cancer growth by regulation of CDKN1C and SMC1A.

    PIK3R3 is upregulated in liver cancer and activates Akt signaling to control cancer growth by regulation of CDKN1C and SMC1A.
    Lin W, Wang K, Mo J, Wang L, Song Z, Jiang H, Wang C, Jin C., Free PMC Article

    07/23/2023
    Identification and targeting of a HES1-YAP1-CDKN1C functional interaction in fusion-negative rhabdomyosarcoma.

    Identification and targeting of a HES1-YAP1-CDKN1C functional interaction in fusion-negative rhabdomyosarcoma.
    Kovach AR, Oristian KM, Kirsch DG, Bentley RC, Cheng C, Chen X, Chen PH, Chi JA, Linardic CM., Free PMC Article

    10/29/2022
    High Maternal Serum Estradiol in First Trimester of Multiple Pregnancy Contributes to Small for Gestational Age via DNMT1-Mediated CDKN1C Upregulation.

    High Maternal Serum Estradiol in First Trimester of Multiple Pregnancy Contributes to Small for Gestational Age via DNMT1-Mediated CDKN1C Upregulation.
    Hu XL, Shi S, Hou NN, Meng Y, Li M, Liu AX, Lu YC, Li JY, Sheng JZ, Zhu YM, Huang HF., Free PMC Article

    04/30/2022
    Loss of p57 Expression in Conceptions Other Than Complete Hydatidiform Mole: A Case Series With Emphasis on the Etiology, Genetics, and Clinical Significance.

    Loss of p57 Expression in Conceptions Other Than Complete Hydatidiform Mole: A Case Series With Emphasis on the Etiology, Genetics, and Clinical Significance.
    Xing D, Miller K, Beierl K, Ronnett BM., Free PMC Article

    02/19/2022
    CDKN1C as a prognostic biomarker correlated with immune infiltrates and therapeutic responses in breast cancer patients.

    CDKN1C as a prognostic biomarker correlated with immune infiltrates and therapeutic responses in breast cancer patients.
    Lai J, Lin X, Cao F, Mok H, Chen B, Liao N., Free PMC Article

    02/19/2022
    Complementary role of p57kip2 immunostaining in diagnosing hydatidiform mole subtypes.

    Complementary role of p57kip2 immunostaining in diagnosing hydatidiform mole subtypes.
    Zainal N, Kampan NC, Rose IM, Ghazali R, Shafiee MN, Yussoff NH, Tamil A, Jamil MA, Hussin NH.

    02/5/2022
    Expression of p57(KIP2) reduces growth and invasion, and induces syncytialization in a human placental choriocarcinoma cell line, BeWo.

    Expression of p57(KIP2) reduces growth and invasion, and induces syncytialization in a human placental choriocarcinoma cell line, BeWo.
    Takahashi K, Yoneyama Y, Koizumi N, Utoguchi N, Kanayama N, Higashi N.

    12/25/2021
    Prenatal molecular testing and diagnosis of Beckwith-Wiedemann syndrome.

    Prenatal molecular testing and diagnosis of Beckwith-Wiedemann syndrome.
    Baker SW, Ryan E, Kalish JM, Ganguly A.

    12/18/2021
    Protein and genetic expression of CDKN1C and IGF2 and clinical features related to human umbilical cord length.

    Protein and genetic expression of CDKN1C and IGF2 and clinical features related to human umbilical cord length.
    Olaya-C M, Ayala-Ramirez P, Sanchez-Barbero AI, Guzmán-P SL, Gil F, Silva JL, Seedbed in Perinatal Medicine, Bernal JE.

    10/30/2021
    Novel mutation points to a hot spot in CDKN1C causing Silver-Russell syndrome.

    Novel mutation points to a hot spot in CDKN1C causing Silver-Russell syndrome.
    Binder G, Ziegler J, Schweizer R, Habhab W, Haack TB, Heinrich T, Eggermann T., Free PMC Article

    10/23/2021
    Dephosphorylation of the Proneural Transcription Factor ASCL1 Re-Engages a Latent Post-Mitotic Differentiation Program in Neuroblastoma.

    Dephosphorylation of the Proneural Transcription Factor ASCL1 Re-Engages a Latent Post-Mitotic Differentiation Program in Neuroblastoma.
    Ali FR, Marcos D, Chernukhin I, Woods LM, Parkinson LM, Wylie LA, Papkovskaia TD, Davies JD, Carroll JS, Philpott A., Free PMC Article

    10/2/2021
    A Beckwith-Wiedemann-Associated CDKN1C Mutation Allows the Identification of a Novel Nuclear Localization Signal in Human p57(Kip2).

    A Beckwith-Wiedemann-Associated CDKN1C Mutation Allows the Identification of a Novel Nuclear Localization Signal in Human p57(Kip2).
    Stampone E, Bencivenga D, Barone C, Di Finizio M, Della Ragione F, Borriello A., Free PMC Article

    09/25/2021
    Variable Expressivity of the Beckwith-Wiedemann Syndrome in Four Pedigrees Segregating Loss-of-Function Variants of CDKN1C.

    Variable Expressivity of the Beckwith-Wiedemann Syndrome in Four Pedigrees Segregating Loss-of-Function Variants of CDKN1C.
    Sparago A, Cerrato F, Pignata L, Cammarata-Scalisi F, Garavelli L, Piscopo C, Vancini A, Riccio A., Free PMC Article

    09/4/2021
    Investigation of (epi)genotype causes and follow-up manifestations in the patients with classical and atypical phenotype of Beckwith-Wiedemann spectrum.

    Investigation of (epi)genotype causes and follow-up manifestations in the patients with classical and atypical phenotype of Beckwith-Wiedemann spectrum.
    Tüysüz B, Güneş N, Geyik F, Yeşil G, Celkan T, Vural M.

    09/4/2021
    Improved molecular detection of mosaicism in Beckwith-Wiedemann Syndrome.

    Improved molecular detection of mosaicism in Beckwith-Wiedemann Syndrome.
    Baker SW, Duffy KA, Richards-Yutz J, Deardorff MA, Kalish JM, Ganguly A., Free PMC Article

    09/4/2021
    Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer.

    Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer.
    Prekovic S, Schuurman K, Mayayo-Peralta I, Manjón AG, Buijs M, Yavuz S, Wellenstein MD, Barrera A, Monkhorst K, Huber A, Morris B, Lieftink C, Chalkiadakis T, Alkan F, Silva J, Győrffy B, Hoekman L, van den Broek B, Teunissen H, Debets DO, Severson T, Jonkers J, Reddy T, de Visser KE, Faller W, Beijersbergen R, Altelaar M, de Wit E, Medema R, Zwart W., Free PMC Article

    08/7/2021
    USP7 promotes proliferation of papillary thyroid carcinoma cells through TBX3-mediated p57(KIP2) repression.

    USP7 promotes proliferation of papillary thyroid carcinoma cells through TBX3-mediated p57(KIP2) repression.
    Xie P, Wang H, Xie J, Huang Z, Chen S, Cheng X, Zhang X, Liu F, Li Y, Huang D.

    07/3/2021
    Regulation of p27(Kip1) and p57(Kip2) Functions by Natural Polyphenols.

    Regulation of p27(Kip1) and p57(Kip2) Functions by Natural Polyphenols.
    Russo GL, Stampone E, Cervellera C, Borriello A., Free PMC Article

    06/26/2021
    CDKN1C-mediated growth inhibition by an EZH1/2 dual inhibitor overcomes resistance of mantle cell lymphoma to ibrutinib.

    CDKN1C-mediated growth inhibition by an EZH1/2 dual inhibitor overcomes resistance of mantle cell lymphoma to ibrutinib.
    Kagiyama Y, Fujita S, Shima Y, Yamagata K, Katsumoto T, Nakagawa M, Honma D, Adachi N, Araki K, Kato A, Inaki K, Ono Y, Fukuhara S, Kobayashi Y, Tobinai K, Kitabayashi I., Free PMC Article

    06/19/2021
    The CDK inhibitor p57(Kip2) enhances the activity of the transcriptional coactivator FHL2.

    The CDK inhibitor p57(Kip2) enhances the activity of the transcriptional coactivator FHL2.
    Kullmann MK, Podmirseg SR, Roilo M, Hengst L., Free PMC Article

    01/9/2021
    Androgenetic Complete Hydatidiform Moles With p57KIP2-Positive Immunostaining.

    Androgenetic Complete Hydatidiform Moles With p57KIP2-Positive Immunostaining.
    Usui H, Sato A, Ota M, Ikeda JI, Shozu M.

    01/2/2021
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