| BCAS2 regulates granulosa cell survival by participating in mRNA alternative splicing. | BCAS2 regulates granulosa cell survival by participating in mRNA alternative splicing.
Yao X, Wang C, Sun L, Yan L, Chen X, Lv Z, Xie X, Tian S, Liu W, Li L, Zhang H, Liu J., Free PMC Article | 06/2/2023 |
| BCAS2, a protein enriched in advanced prostate cancer, interacts with NBS1 to enhance DNA double-strand break repair. | BCAS2, a protein enriched in advanced prostate cancer, interacts with NBS1 to enhance DNA double-strand break repair.
Wang LP, Chen TY, Kang CK, Huang HP, Chen SL., Free PMC Article | 04/3/2021 |
| BCAS2 is an AF-1 coactivator of ERalpha whose overexpression promotes carcinogenic processes, suggesting an important role in the development of estrogen-receptor positive breast cancer. | BCAS2 Enhances Carcinogenic Effects of Estrogen Receptor Alpha in Breast Cancer Cells.
Salmerón-Hernández Á, Noriega-Reyes MY, Jordan A, Baranda-Avila N, Langley E., Free PMC Article | 06/8/2019 |
| Study showed that CDK4 and BCAS2 may be target genes of miR-486 and levels of CDK4 and BCAS2 were both significantly higher in the esophageal cancer tissues and cell lines than levels in the normal tissues and cells. | miR-486 functions as a tumor suppressor in esophageal cancer by targeting CDK4/BCAS2.
Lang B, Zhao S., Free PMC Article | 07/21/2018 |
| Chromosomal breakpoints involved the BCAS2 gene in 1q31 is associated with Diffuse Large B-Cell Lymphomas. | Novel IGH and MYC Translocation Partners in Diffuse Large B-Cell Lymphomas.
Otto C, Scholtysik R, Schmitz R, Kreuz M, Becher C, Hummel M, Rosenwald A, Trümper L, Klapper W, Siebert R, Küppers R, “Molecular Mechanisms in Malignant Lymphomas” Network Project. | 07/22/2017 |
| BCAS2 interacts with HSF4 and negatively regulates its protein stability via ubiquitination. | BCAS2 interacts with HSF4 and negatively regulates its protein stability via ubiquitination.
Liao S, Du R, Wang L, Qu Z, Cui X, Li C, Liu F, Huang M, Wang J, Chen J, Gao M, Yu S, Tang Z, Li DW, Jiang T, Liu M. | 08/13/2016 |
| These results demonstrate that Aurora B inhibits both direct interaction with the microtubule and oligomerization of the Dam1 complex to drive error correction during mitosis. | The molecular architecture of the Dam1 kinetochore complex is defined by cross-linking based structural modelling.
Zelter A, Bonomi M, Kim JO, Umbreit NT, Hoopmann MR, Johnson R, Riffle M, Jaschob D, MacCoss MJ, Moritz RL, Davis TN., Free PMC Article | 05/21/2016 |
| BCAS2 is a novel androgen receptor-interacting protein. | BCAS2 promotes prostate cancer cells proliferation by enhancing AR mRNA transcription and protein stability.
Kuo PC, Huang CW, Lee CI, Chang HW, Hsieh SW, Chung YP, Lee MS, Huang CS, Tsao LP, Tsao YP, Chen SL., Free PMC Article | 03/21/2015 |
| ERRbeta signalling leads to BCAS2-mediated blockage of the G1/S transition and inhibition of the epithelial to mesenchymal transition through FST-mediated regulation of E-cadherin | ERRβ signalling through FST and BCAS2 inhibits cellular proliferation in breast cancer cells.
Sengupta D, Bhargava DK, Dixit A, Sahoo BS, Biswas S, Biswas G, Mishra SK., Free PMC Article | 06/7/2014 |
| BCAS2 directly interacts with p53 to reduce p53 transcriptional activity by mildly but consistently decreasing p53 protein in the absence of DNA damage. In the presence of DNA damage, BCAS2 prominently reduces p53 protein. | Breast cancer amplified sequence 2, a novel negative regulator of the p53 tumor suppressor.
Kuo PC, Tsao YP, Chang HW, Chen PH, Huang CW, Lin ST, Weng YT, Tsai TC, Shieh SY, Chen SL. | 01/21/2010 |
| The BCAS2 gene was amplified in two of 60 primary breast cancer tissues, but not in other cancer cells, providing the first evidence of amplification within this region and indicating that BCAS2 gene codes for a nuclear protein. | Amplification of the BCAS2 gene at chromosome 1p13.3-21 in human primary breast cancer.
Maass N, Rösel F, Schem C, Hitomi J, Jonat W, Nagasaki K. | 01/21/2010 |
| This study suggested that BCAS2 might play an important role in breast cancer development by increasing the estrogen receptor's function. | Potentiation of estrogen receptor transcriptional activity by breast cancer amplified sequence 2.
Qi C, Zhu YT, Chang J, Yeldandi AV, Rao MS, Zhu YJ. | 01/21/2010 |