| ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms. | ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms.
Tian J, Ashique AM, Weeks S, Lan T, Yang H, Chen HH, Song C, Koyano K, Mondal K, Tsai D, Cheung I, Moshrefi M, Kekatpure A, Fan B, Li B, Qurashi S, Rocha L, Aguayo J, Rodgers C, Meza M, Heeke D, Medfisch SM, Chu C, Starck S, Basak NP, Sankaran S, Malhotra M, Crawley S, Tran TT, Duey DY, Ho C, Mikaelian I, Liu W, Rivera LB, Huang J, Paavola KJ, O'Hollaren K, Blum LK, Lin VY, Chen P, Iyer A, He S, Roda JM, Wang Y, Sissons J, Kutach AK, Kaplan DD, Stone GW. | 05/28/2024 |
| ILT4 reprograms glucose metabolism to promote tumor progression in triple-negative breast cancer. | ILT4 reprograms glucose metabolism to promote tumor progression in triple-negative breast cancer.
Zhang H, Gao A, Liu Q, Zhang F, Wang S, Chen X, Shi W, Zhang Y, Liu Q, Zheng Y, Sun Y. | 09/20/2023 |
| LILRB2/PirB mediates macrophage recruitment in fibrogenesis of nonalcoholic steatohepatitis. | LILRB2/PirB mediates macrophage recruitment in fibrogenesis of nonalcoholic steatohepatitis.
Li DP, Huang L, Kan RR, Meng XY, Wang SY, Zou HJ, Guo YM, Luo PQ, Pan LM, Xiang YX, Mao BB, Xie YY, Wang ZH, Yang M, He R, Yang Y, Liu ZL, Xie JH, Ma DL, Zhang BP, Shao SY, Chen X, Xu SM, He WT, Li WJ, Chen Y, Yu XF., Free PMC Article | 07/27/2023 |
| Genetic diversity of the LILRB1 and LILRB2 coding regions in an admixed Brazilian population sample. | Genetic diversity of the LILRB1 and LILRB2 coding regions in an admixed Brazilian population sample.
Oliveira MLG, Castelli EC, Veiga-Castelli LC, Pereira ALE, Marcorin L, Carratto TMT, Souza AS, Andrade HS, Simões AL, Donadi EA, Courtin D, Sabbagh A, Giuliatti S, Mendes-Junior CT. | 10/1/2022 |
| Placental Malaria is Associated with Higher LILRB2 Expression in Monocyte Subsets and Lower Anti-Malarial IgG Antibodies During Infancy. | Placental Malaria is Associated with Higher LILRB2 Expression in Monocyte Subsets and Lower Anti-Malarial IgG Antibodies During Infancy.
Dechavanne C, Nouatin O, Adamou R, Edslev S, Hansen A, Meurisse F, Sadissou I, Gbaguidi E, Milet J, Cottrell G, Gineau L, Sabbagh A, Massougbodji A, Moutairou K, Donadi EA, Carosella ED, Moreau P, Remarque E, Theisen M, Rouas-Freiss N, Garcia A, Favier B, Courtin D., Free PMC Article | 08/13/2022 |
| Antibody-Mediated LILRB2-Receptor Antagonism Induces Human Myeloid-Derived Suppressor Cells to Kill Mycobacterium tuberculosis. | Antibody-Mediated LILRB2-Receptor Antagonism Induces Human Myeloid-Derived Suppressor Cells to Kill Mycobacterium tuberculosis.
Singh VK, Khan A, Xu Y, Mai S, Zhang L, Mishra A, Restrepo BI, Pan PY, Chen SH, Jagannath C., Free PMC Article | 07/9/2022 |
| LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions. | LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions.
Zhao P, Xu Y, Jiang LL, Fan X, Ku Z, Li L, Liu X, Deng M, Arase H, Zhu JJ, Huang TY, Zhao Y, Zhang C, Xu H, Tong Q, Zhang N, An Z., Free PMC Article | 07/2/2022 |
| Prognostic significance of the immune checkpoint HLA-G/ILT-4 in the survival of patients with gastric cancer. | Prognostic significance of the immune checkpoint HLA-G/ILT-4 in the survival of patients with gastric cancer.
Chen QY, Zhou WJ, Zhang JG, Zhang X, Han QY, Lin A, Yan WH. | 06/25/2022 |
| Tumor-derived ILT4 induces T cell senescence and suppresses tumor immunity. | Tumor-derived ILT4 induces T cell senescence and suppresses tumor immunity.
Gao A, Liu X, Lin W, Wang J, Wang S, Si F, Huang L, Zhao Y, Sun Y, Peng G., Free PMC Article | 12/18/2021 |
| Prognostic Significance of Immune Checkpoints HLA-G/ILT-2/4 and PD-L1 in Colorectal Cancer. | Prognostic Significance of Immune Checkpoints HLA-G/ILT-2/4 and PD-L1 in Colorectal Cancer.
Chen QY, Chen YX, Han QY, Zhang JG, Zhou WJ, Zhang X, Ye YH, Yan WH, Lin A., Free PMC Article | 10/30/2021 |
| Plasmodium falciparum RIFIN is a novel ligand for inhibitory immune receptor LILRB2. | Plasmodium falciparum RIFIN is a novel ligand for inhibitory immune receptor LILRB2.
Sakoguchi A, Saito F, Hirayasu K, Shida K, Matsuoka S, Itagaki S, Nakai W, Kohyama M, Suenaga T, Iwanaga S, Horii T, Arase H. | 09/11/2021 |
| The expression and function of immunoglobulin-like transcript 4 in dendritic cells from patients with hepatocellular carcinoma. | The expression and function of immunoglobulin-like transcript 4 in dendritic cells from patients with hepatocellular carcinoma.
Fan J, Han J, Li J, Gu A, Yin D, Song F, Wang L, Yi Y. | 08/28/2021 |
| ILT4 inhibition prevents TAM- and dysfunctional T cell-mediated immunosuppression and enhances the efficacy of anti-PD-L1 therapy in NSCLC with EGFR activation. | ILT4 inhibition prevents TAM- and dysfunctional T cell-mediated immunosuppression and enhances the efficacy of anti-PD-L1 therapy in NSCLC with EGFR activation.
Chen X, Gao A, Zhang F, Yang Z, Wang S, Fang Y, Li J, Wang J, Shi W, Wang L, Zheng Y, Sun Y., Free PMC Article | 07/24/2021 |
| The immune-checkpoint HLA-G/ILT4 is involved in the regulation of VEGF expression in clear cell renal cell carcinoma. | The immune-checkpoint HLA-G/ILT4 is involved in the regulation of VEGF expression in clear cell renal cell carcinoma.
García M, Palma MB, Verine J, Miriuka S, Inda AM, Errecalde AL, Desgrandchamps F, Carosella ED, Tronik-Le Roux D., Free PMC Article | 02/2/2021 |
| The Interaction of LILRB2 with HLA-B Is Associated with Psoriasis Susceptibility. | The Interaction of LILRB2 with HLA-B Is Associated with Psoriasis Susceptibility.
Yanovsky RL, Chen H, Leslie S, Carrington M, Liao W., Free PMC Article | 01/9/2021 |
| Study revealed the coexpression of ILT4 and human leukocyte antigenG (HLAG) in tissues of human primary colorectal cancer (CRC) and its association with older age, advanced stage, regional lymph node involvement and poor overall survival time. Results indicated that the interaction of ILT4 and its ligand HLAG promotes CRC progression through AKT and ERK signal activation. | Immunoglobulin‑like transcript 4 and human leukocyte antigen‑G interaction promotes the progression of human colorectal cancer.
Cai Z, Wang L, Han Y, Gao W, Wei X, Gong R, Zhu M, Sun Y, Yu S., Free PMC Article | 08/31/2019 |
| Mechanistically, LILRB2 enhances the SHP2/CaMK1/CREB signaling pathways to support the expansion and migration of the endometrial cancer cells. | Immune inhibitory receptor LILRB2 is critical for the endometrial cancer progression.
Shao H, Ma L, Jin F, Zhou Y, Tao M, Teng Y. | 05/25/2019 |
| LILRB2 is overexpressed in human HCC tissues and is associated with patients' poor survival. LILRB2 may serve as a marker for poor prognosis of HCC. | Expression of leukocyte immunoglobulin-like receptor B2 in hepatocellular carcinoma and its clinical significance.
Li X, Wei X, Xu H, Sha Z, Gao A, Sun Y, Li J, Xu L. | 02/23/2019 |
| miR-10 can promote microglia cell proliferation and inhibit the inflammatory cytokine secretion via targeting the NgR gene to down-regulate its expression. | MiR-10 targets NgR to modulate the proliferation of microglial cells and the secretion of inflammatory cytokines.
Wang W, Zhan R, Zhou J, Wang J, Chen S. | 01/5/2019 |
| Results show that LILRB2 rs383369:AG predisposed to the endometriosis and its progression. | The impact of HLA-G, LILRB1 and LILRB2 gene polymorphisms on susceptibility to and severity of endometriosis.
Bylińska A, Wilczyńska K, Malejczyk J, Milewski Ł, Wagner M, Jasek M, Niepiekło-Miniewska W, Wiśniewski A, Płoski R, Barcz E, Roszkowski P, Kamiński P, Malinowski A, Wilczyński JR, Radwan P, Radwan M, Kuśnierczyk P, Nowak I., Free PMC Article | 05/26/2018 |
| ILT-4 is a receptor for hSEMA4A)on activated CD4(+) T cells. hSEMA4A is highly expressed in human asthmatic lung tissue. | Human Semaphorin-4A drives Th2 responses by binding to receptor ILT-4.
Lu N, Li Y, Zhang Z, Xing J, Sun Y, Yao S, Chen L., Free PMC Article | 03/24/2018 |
| LILRB2 protein and mRNA expressions are deregulated on monocytes after septic shock | Modulation of LILRB2 protein and mRNA expressions in septic shock patients and after ex vivo lipopolysaccharide stimulation.
Venet F, Schilling J, Cazalis MA, Demaret J, Poujol F, Girardot T, Rouget C, Pachot A, Lepape A, Friggeri A, Rimmelé T, Monneret G, Textoris J. | 02/17/2018 |
| this study shows that sHLA-G causes a functional and quantitative induction of myeloid-derived suppressor cells through engagement of ILT4 and activation of STAT3 | HLA-G promotes myeloid-derived suppressor cell accumulation and suppressive activity during human pregnancy through engagement of the receptor ILT4.
Köstlin N, Ostermeir AL, Spring B, Schwarz J, Marmé A, Walter CB, Poets CF, Gille C. | 07/8/2017 |
| LILRB2 expression is significantly upregulated in human masticatory mucosa during wound healing | Human gingiva transcriptome during wound healing.
Wang Y, Tatakis DN. | 03/22/2017 |
| our results indicate that the ILT4-HLA-G interaction might play an important role in Non-small cell lung cancer progression | Co-expression of ILT4/HLA-G in human non-small cell lung cancer correlates with poor prognosis and ILT4-HLA-G interaction activates ERK signaling.
Zhang Y, Zhao J, Qiu L, Zhang P, Li J, Yang D, Wei X, Han Y, Nie S, Sun Y. | 02/18/2017 |