| PAK4 Is Involved in the Stabilization of PD-L1 and the Resistance to Doxorubicin in Osteosarcoma and Predicts the Survival of Diagnosed Patients. | PAK4 Is Involved in the Stabilization of PD-L1 and the Resistance to Doxorubicin in Osteosarcoma and Predicts the Survival of Diagnosed Patients.
Zhang J, Song Y, Ahn AR, Park HS, Park SH, Moon YJ, Kim KM, Jang KY., Free PMC Article | 11/5/2024 |
| Tumorigenic role of Pak4 in ovarian cancer and its correlation with immune infiltration. | Tumorigenic role of Pak4 in ovarian cancer and its correlation with immune infiltration.
Tang L, Ye H, Chen L, Dong W, Hu X, Yu L., Free PMC Article | 08/22/2024 |
| TBC1D10B promotes tumor progression in colon cancer via PAK4-mediated promotion of the PI3K/AKT/mTOR pathway. | TBC1D10B promotes tumor progression in colon cancer via PAK4‑mediated promotion of the PI3K/AKT/mTOR pathway.
Chi XJ, Song YB, Zhang H, Wei LQ, Gao Y, Miao XJ, Yang ST, Lin CY, Lan D, Zhang X. | 08/21/2024 |
| PAK4 phosphorylates and inhibits AMPKalpha to control glucose uptake. | PAK4 phosphorylates and inhibits AMPKα to control glucose uptake.
Wu D, Yu HC, Cha HN, Park S, Lee Y, Yoon SJ, Park SY, Park BH, Bae EJ., Free PMC Article | 08/14/2024 |
| The role of p21-activated kinase 4 in the progression of oral squamous cell carcinoma by targeting PI3K-AKT signaling pathway. | The role of p21-activated kinase 4 in the progression of oral squamous cell carcinoma by targeting PI3K-AKT signaling pathway.
Zhang L, Lin S, Zhang Z, Yan C, Liu F. | 02/27/2023 |
| Pan-cancer analysis identifies the immunological and prognostic role of PAK4. | Pan-cancer analysis identifies the immunological and prognostic role of PAK4.
Tang L, Gao Y, Li T. | 12/31/2022 |
| PAK4 expression is associated with the prognosis in non-small cell lung cancer. | PAK4 expression is associated with the prognosis in non-small cell lung cancer.
Li C, Ji D, Duan A, Jiang Q., Free PMC Article | 08/27/2022 |
| PAK4 in cancer development: Emerging player and therapeutic opportunities. | PAK4 in cancer development: Emerging player and therapeutic opportunities.
Yuan Y, Zhang H, Li D, Li Y, Lin F, Wang Y, Song H, Liu X, Li F, Zhang J. | 08/20/2022 |
| Targeting of p21-Activated Kinase 4 Radiosensitizes Glioblastoma Cells via Impaired DNA Repair. | Targeting of p21-Activated Kinase 4 Radiosensitizes Glioblastoma Cells via Impaired DNA Repair.
Blankenstein LJ, Cordes N, Kunz-Schughart LA, Vehlow A., Free PMC Article | 08/13/2022 |
| miR-425 regulates ovarian cancer proliferation, metastasis, and apoptosis by repressing PAK4 expression. | miR-425 regulates ovarian cancer proliferation, metastasis, and apoptosis by repressing PAK4 expression.
Wang Y, Shao F, Chen L. | 02/12/2022 |
| cAMP Response Element Binding-Protein- and Phosphorylation-Dependent Regulation of Tyrosine Hydroxylase by PAK4: Implications for Dopamine Replacement Therapy. | cAMP Response Element Binding-Protein- and Phosphorylation-Dependent Regulation of Tyrosine Hydroxylase by PAK4: Implications for Dopamine Replacement Therapy.
Won SY, You ST, Choi SW, McLean C, Shin EY, Kim EG., Free PMC Article | 12/25/2021 |
| Silencing of SETD6 inhibits the tumorigenesis of oral squamous cell carcinoma by inhibiting methylation of PAK4 and RelA. | Silencing of SETD6 inhibits the tumorigenesis of oral squamous cell carcinoma by inhibiting methylation of PAK4 and RelA.
Huang W, Liu H, Lv T. | 12/25/2021 |
| Proximity proteomics identifies PAK4 as a component of Afadin-Nectin junctions. | Proximity proteomics identifies PAK4 as a component of Afadin-Nectin junctions.
Baskaran Y, Tay FP, Ng EYW, Swa CLF, Wee S, Gunaratne J, Manser E., Free PMC Article | 10/9/2021 |
| Why is PAK4 overexpressed in cancer? | Why is PAK4 overexpressed in cancer?
Costa TDF, Strömblad S. | 10/2/2021 |
| Recognition of physiological phosphorylation sites by p21-activated kinase 4. | Recognition of physiological phosphorylation sites by p21-activated kinase 4.
Chetty AK, Sexton JA, Ha BH, Turk BE, Boggon TJ., Free PMC Article | 08/14/2021 |
| p21-activated kinases as viable therapeutic targets for the treatment of high-risk Ewing sarcoma. | p21-activated kinases as viable therapeutic targets for the treatment of high-risk Ewing sarcoma.
Qasim SL, Sierra L, Shuck R, Kurenbekova L, Patel TD, Rajapakshe K, Wulff J, Nakahata K, Kim HR, Landesman Y, Unger TJ, Coarfa C, Yustein JT. | 07/31/2021 |
| Targeting PAK4 Inhibits Ras-Mediated Signaling and Multiple Oncogenic Pathways in High-Risk Rhabdomyosarcoma. | Targeting PAK4 Inhibits Ras-Mediated Signaling and Multiple Oncogenic Pathways in High-Risk Rhabdomyosarcoma.
Dasgupta A, Sierra L, Tsang SV, Kurenbekova L, Patel T, Rajapakse K, Shuck RL, Rainusso N, Landesman Y, Unger T, Coarfa C, Yustein JT., Free PMC Article | 05/8/2021 |
| PAK4 suppresses TNF-induced release of endothelial microparticles in HUVECs cells. | PAK4 suppresses TNF-induced release of endothelial microparticles in HUVECs cells.
Zhang S, Yin Y, Li C, Zhao Y, Wang Q, Zhang X., Free PMC Article | 03/6/2021 |
| PAK4 methylation by the methyltransferase SETD6 attenuates cell adhesion. | PAK4 methylation by the methyltransferase SETD6 attenuates cell adhesion.
Vershinin Z, Feldman M, Levy D., Free PMC Article | 02/2/2021 |
| Pancreatic stellate cells derived exosomal miR-5703 promotes pancreatic cancer by downregulating CMTM4 and activating PI3K/Akt pathway. | Pancreatic stellate cells derived exosomal miR-5703 promotes pancreatic cancer by downregulating CMTM4 and activating PI3K/Akt pathway.
Li M, Guo H, Wang Q, Chen K, Marko K, Tian X, Yang Y. | 01/23/2021 |
| PAK4 Kinase Activity Plays a Crucial Role in the Podosome Ring of Myeloid Cells. | PAK4 Kinase Activity Plays a Crucial Role in the Podosome Ring of Myeloid Cells.
Foxall E, Staszowska A, Hirvonen LM, Georgouli M, Ciccioli M, Rimmer A, Williams L, Calle Y, Sanz-Moreno V, Cox S, Jones GE, Wells CM., Free PMC Article | 09/26/2020 |
| Proteomic and Interactome Approaches Reveal PAK4, PHB-2, and 14-3-3eta as Targets of Overactivated Cdc42 in Cellular Responses to Genomic Instability. | Proteomic and Interactome Approaches Reveal PAK4, PHB-2, and 14-3-3η as Targets of Overactivated Cdc42 in Cellular Responses to Genomic Instability.
Silva LE, Souza RC, Kitano ES, Monteiro LF, Iwai LK, Forti FL. | 09/5/2020 |
| Targeting Rho GTPase effector p21 activated kinase 4 (PAK4) suppresses p-Bad-microRNA drug resistance axis leading to inhibition of pancreatic ductal adenocarcinoma proliferation. | Targeting Rho GTPase effector p21 activated kinase 4 (PAK4) suppresses p-Bad-microRNA drug resistance axis leading to inhibition of pancreatic ductal adenocarcinoma proliferation.
Mohammad RM, Li Y, Muqbil I, Aboukameel A, Senapedis W, Baloglu E, Landesman Y, Philip PA, Azmi AS., Free PMC Article | 04/11/2020 |
| Results demonstrated that PAK4 plays an important role in melanoma cell invasion by promoting maturation and/or degradation of the invadopodia through the localized inhibition of PDZ-RhoGEF. Its loss of expression leads to changes in invadopodia dynamics. | Differential role for PAK1 and PAK4 during the invadopodia lifecycle.
Nicholas NS, Pipili A, Lesjak MS, Wells CM., Free PMC Article | 04/11/2020 |
| miR-9-5p directly targeted the 3'-UTR of PAK4 mRNA and negatively regulated its expression. | PAK4, a target of miR-9-5p, promotes cell proliferation and inhibits apoptosis in colorectal cancer.
Wang M, Gao Q, Chen Y, Li Z, Yue L, Cao Y., Free PMC Article | 04/11/2020 |