| Relationship between the Number of Repeats in the Neck Regions of L-SIGN and Augmented Virus Replication and Immune Responses in Dengue Hemorrhagic Fever. | Relationship between the Number of Repeats in the Neck Regions of L-SIGN and Augmented Virus Replication and Immune Responses in Dengue Hemorrhagic Fever.
Liu KS, Chen PM, Wang L, Lee IK, Yang KD, Chen RF., Free PMC Article | 08/15/2024 |
| ACE2, TMPRSS2, and L-SIGN Expression in Placentae From HIV-Positive Pregnancies Exposed to Antiretroviral Therapy-Implications for SARS-CoV-2 Placental Infection. | ACE2, TMPRSS2, and L-SIGN Expression in Placentae From HIV-Positive Pregnancies Exposed to Antiretroviral Therapy-Implications for SARS-CoV-2 Placental Infection.
Kala S, Meteleva K, Serghides L., Free PMC Article | 12/25/2021 |
| CLEC4M overexpression inhibits progression and is associated with a favorable prognosis in hepatocellular carcinoma. | CLEC4M overexpression inhibits progression and is associated with a favorable prognosis in hepatocellular carcinoma.
Yu Q, Gao K., Free PMC Article | 04/24/2021 |
| CLEC4M is a novel clearance receptor that interacts with mannose-exposed glycans on FVIII in the presence or absence of VWF. | The endothelial lectin clearance receptor CLEC4M binds and internalizes factor VIII in a VWF-dependent and independent manner.
Swystun LL, Notley C, Georgescu I, Lai JD, Nesbitt K, James PD, Lillicrap D., Free PMC Article | 04/18/2020 |
| heterozygous VNTR genotypes 57 and 67 of CLEC4M were highly enriched and are the most likely mechanism through which CLEC4M contributes to disease in the Swedish type 1 VWD population | Genetic variation in the C-type lectin receptor CLEC4M in type 1 von Willebrand Disease patients.
Manderstedt E, Lind-Halldén C, Lethagen S, Halldén C., Free PMC Article | 03/17/2018 |
| DC-SIGNR promoted gastric cancer liver metastasis mediated with HNRNPKP2 which expression was regulated by STAT5A. And HNRNPKP2 decreased the expression of downstream target gene CXCR4. These findings indicated potential therapeutic candidates for gastric cancer liver metastasis. | DC - SIGNR by influencing the lncRNA HNRNPKP2 upregulates the expression of CXCR4 in gastric cancer liver metastasis.
Zhang Y, Zhang Q, Zhang M, Yuan M, Wang Z, Zhang J, Zhou X, Zhang Y, Lin F, Na H, Ren S, Zuo Y., Free PMC Article | 07/29/2017 |
| the neck domains of DC-SIGN and DC-SIGNR can contribute to the different functions of these receptors by presenting the sugar-binding sites in different contexts. | Oligomerization domains in the glycan-binding receptors DC-SIGN and DC-SIGNR: Sequence variation and stability differences.
Dos Santos Á, Hadjivasiliou A, Ossa F, Lim NK, Turgut A, Taylor ME, Drickamer K., Free PMC Article | 07/15/2017 |
| Together, these studies confirm a role for C-type lectin receptors DC-SIGN and L-SIGN as attachment factors and entry receptors for human metapneumovirus infection. | DC-SIGN and L-SIGN Are Attachment Factors That Promote Infection of Target Cells by Human Metapneumovirus in the Presence or Absence of Cellular Glycosaminoglycans.
Gillespie L, Gerstenberg K, Ana-Sosa-Batiz F, Parsons MS, Farrukee R, Krabbe M, Spann K, Brooks AG, Londrigan SL, Reading PC., Free PMC Article | 05/13/2017 |
| DC-SIGNR VNTR and DC-SIGN VNTR were not associated with the risk of pulmonary tuberculosis in a sample of Iranian population | Association of DC-SIGN and DC-SIGNR Repeat Regions with Susceptibility to Pulmonary Tuberculosis in Zahedan, Southeastern Iran.
Naderi M, Hashemi M, Soroush N, Amininia S, Taheri M. | 01/14/2017 |
| CD209L variation may influence susceptibility to HIV-1, response to treatment, and disease progression. | Association of CD209L tandem repeats polymorphism with susceptibility to human immunodeficiency virus-1 infection, disease progression, and treatment outcomes: a Moroccan cohort study.
Fayssel N, Bensghir R, Ouladlahsen A, Abdelghaffar H, Sodqi M, Lahlou K, Benjelloun S, Marhoum El Filali K, Ezzikouri S, Wakrim L. | 07/30/2016 |
| DC-SIGNR expression in peripheral blood mononuclear cells was higher in HIV-1-infected patients, and its positive correlation with viral load and negative with CD4+ T cells counts suggest a potential role of DC-SIGNR in HIV-1 infection. | Association of DC-SIGNR Expression in Peripheral Blood Mononuclear Cells with DC-SIGNR Genotypes in HIV-1 Infection.
Chaudhary O, Kumar S, Bala M, Singh J, Hazarika A, Luthra K. | 07/2/2016 |
| Study demonstrated that serum levels of DC-SIGNR in lung cancer patients were significantly lower than those in healthy individuals, and correlated significantly with brain metastasis and serum NK cells percentage. | Low expression of dendritic cell-specific intercellular adhesion molecule-grabbing nonintegrin-related protein in lung cancer and significant correlations with brain metastasis and natural killer cells.
Liu X, Zhang H, Su L, Yang P, Xin Z, Zou J, Ren S, Zuo Y., Free PMC Article | 06/4/2016 |
| Genetic variations in STXBP5 and CLEC4M are associated with VWF level variation in type 1, but not in type 2 von Willebrand disease. | CLEC4M and STXBP5 gene variations contribute to von Willebrand factor level variation in von Willebrand disease.
Sanders YV, van der Bom JG, Isaacs A, Cnossen MH, de Maat MP, Laros-van Gorkom BA, Fijnvandraat K, Meijer K, van Duijn CM, Mauser-Bunschoten EP, Eikenboom J, Leebeek FW, WiN Study Group. | 02/27/2016 |
| of an association between CD209 and CD209L polymorphisms and tuberculosis development in a Brazilian population | Association of CD209 and CD209L polymorphisms with tuberculosis infection in a Northeastern Brazilian population.
da Silva RC, Segat L, da Cruz HL, Schindler HC, Montenegro LM, Crovella S, Guimarães RL. | 10/31/2015 |
| DC-SIGN and DC-SIGNR are blood-based molecular markers that can potentially be used for the diagnosis of early stage patients | The clinical significance of DC-SIGN and DC-SIGNR, which are novel markers expressed in human colon cancer.
Jiang Y, Zhang C, Chen K, Chen Z, Sun Z, Zhang Z, Ding D, Ren S, Zuo Y., Free PMC Article | 10/3/2015 |
| Japanese encephalitis virus infected cells through three virus receptors: DC-SIGN, DC-SIGNR and LSECtin. | Distinct usage of three C-type lectins by Japanese encephalitis virus: DC-SIGN, DC-SIGNR, and LSECtin.
Shimojima M, Takenouchi A, Shimoda H, Kimura N, Maeda K., Free PMC Article | 03/21/2015 |
| The results indicate that neck region polymorphism of L-SIGN can influence the outcome of HCV infection and the four-tandem repeat is associated with clearance of HCV infection. | The allele 4 of neck region liver-lymph node-specific ICAM-3-grabbing integrin variant is associated with spontaneous clearance of hepatitis C virus and decrease of viral loads.
Ezzikouri S, Rebbani K, Fakhir FZ, Alaoui R, Nadir S, Diepolder H, Thursz M, Khakoo SI, Benjelloun S., Free PMC Article | 02/21/2015 |
| CLEC4M and CD81 both are still crucial for hepatitis C virus entry into hepatocytes. | CLEC4M-positive and CD81-negative Huh7 cells are not susceptible to JFH-1 HCVcc infection but mediate transinfection.
Ishibashi M, Morita N, Nomura-Kawaguchi C, Shimizu Y, Wakita T, Esumi M., Free PMC Article | 12/27/2014 |
| The CLEC4M carbohydrate recognition domain rapidly and reversibly releases glycan ligands and Ca(2+) at reduced pH. | NMR evidence for oligosaccharide release from the dendritic-cell specific intercellular adhesion molecule 3-grabbing non-integrin-related (CLEC4M) carbohydrate recognition domain at low pH.
Probert F, Mitchell DA, Dixon AM., Free PMC Article | 10/18/2014 |
| these results provide evidence that hDC- and hL-SIGN can mediate the entry of Junin virus into cells, and may play an important role in virus infection and dissemination in the host. | Utilization of human DC-SIGN and L-SIGN for entry and infection of host cells by the New World arenavirus, Junín virus.
Martinez MG, Bialecki MA, Belouzard S, Cordo SM, Candurra NA, Whittaker GR., Free PMC Article | 03/29/2014 |
| Up-regulation of Raf-MEK-ERK pathway by HCV E2 via L-SIGN provides new insights into signaling cascade of L-SIGN | Interaction of L-SIGN with hepatitis C virus envelope protein E2 up-regulates Raf-MEK-ERK pathway.
Zhao LJ, Wang W, Ren H, Qi ZT., Free PMC Article | 03/8/2014 |
| Our findings suggested that DC-SIGNR neck region VNTR polymorphism was not directly associated with hosts' predisposition for HIV-1 infection and not associated with the HIV-1 routes of infection. | The VNTR polymorphism of the CLEC4M gene and susceptibility to HIV-1 infection in Han Chinese population.
Li H, Fu WP, Hong ZH. | 01/18/2014 |
| DC-SIGNR has a role in expression of lactic acid dehydrogenase and beta2-microglobulin in non-Hodgkin lymphoma | Low expression of dendritic cell-specific intercellular adhesion molecule-grabbing nonintegrin-related protein in non-Hodgkin lymphoma and significant correlations with lactic acid dehydrogenase and β2-microglobulin.
Zhang Z, Chen K, Yan L, Yang Z, Zhu Z, Chen C, Zeng J, Wei W, Qi X, Ren S, Zuo Y. | 01/4/2014 |
| genetic polymorphism is associated with HIV-1 infection | The DC-SIGNR 7/5 genotype is associated with high dendritic cell counts and their subsets in patients infected with HIV-1.
Chaudhary O, Bala M, Singh J, Hazarika A, Kumar R, Luthra K. | 11/16/2013 |
| Variable number of tandem repeats in CLEC4M is associated with type 1 von Willebrand disease. | The C-type lectin receptor CLEC4M binds, internalizes, and clears von Willebrand factor and contributes to the variation in plasma von Willebrand factor levels.
Rydz N, Swystun LL, Notley C, Paterson AD, Riches JJ, Sponagle K, Boonyawat B, Montgomery RR, James PD, Lillicrap D., Free PMC Article | 09/21/2013 |