| ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism. | ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism.
Kawatani K, Holm ML, Starling SC, Martens YA, Zhao J, Lu W, Ren Y, Li Z, Jiang P, Jiang Y, Baker SK, Wang N, Roy B, Parsons TM, Perkerson RB 3rd, Bao H, Han X, Bu G, Kanekiyo T., Free PMC Article | 06/13/2024 |
| CSF biomarker analysis of ABCA7 mutation carriers suggests altered APP processing and reduced inflammatory response. | CSF biomarker analysis of ABCA7 mutation carriers suggests altered APP processing and reduced inflammatory response.
Duchateau L, Küҫükali F, De Roeck A, Wittens MMJ, Temmerman J, Weets I, Timmers M, Engelborghs S, Bjerke M, Sleegers K., Free PMC Article | 11/15/2023 |
| Down-Regulation of ABCA7 in Human Microglia, Astrocyte and THP-1 Cell Lines by Cholesterol Depletion, IL-1beta and TNFalpha, or PMA. | Down-Regulation of ABCA7 in Human Microglia, Astrocyte and THP-1 Cell Lines by Cholesterol Depletion, IL-1β and TNFα, or PMA.
Wiener JP, Desire S, Garliyev V, Lyssenko Iii N, Praticò D, Lyssenko NN., Free PMC Article | 09/22/2023 |
| ABCA7-Associated Clinical Features and Molecular Mechanisms in Alzheimer's Disease. | ABCA7-Associated Clinical Features and Molecular Mechanisms in Alzheimer's Disease.
Qian XH, Chen SY, Liu XL, Tang HD. | 09/6/2023 |
| High-Quality Sleep Mitigates ABCA7-Related Generalization Deficits in Healthy Older African Americans. | High-Quality Sleep Mitigates ABCA7-Related Generalization Deficits in Healthy Older African Americans.
Sinha N, Fausto BA, Mander B, Gluck MA., Free PMC Article | 07/12/2023 |
| Aberrant DNA Methylation, Expression, and Occurrence of Transcript Variants of the ABC Transporter ABCA7 in Breast Cancer. | Aberrant DNA Methylation, Expression, and Occurrence of Transcript Variants of the ABC Transporter ABCA7 in Breast Cancer.
Zappe K, Kopic A, Scheichel A, Schier AK, Schmidt LE, Borutzki Y, Miedl H, Schreiber M, Mendrina T, Pirker C, Pfeiler G, Hacker S, Haslik W, Pils D, Bileck A, Gerner C, Meier-Menches S, Heffeter P, Cichna-Markl M., Free PMC Article | 06/14/2023 |
| Cryo-EM structures of human ABCA7 provide insights into its phospholipid translocation mechanisms. | Cryo-EM structures of human ABCA7 provide insights into its phospholipid translocation mechanisms.
Le LTM, Thompson JR, Dehghani-Ghahnaviyeh S, Pant S, Dang PX, French JB, Kanikeyo T, Tajkhorshid E, Alam A., Free PMC Article | 02/11/2023 |
| SNP-by-CpG Site Interactions in ABCA7 Are Associated with Cognition in Older African Americans. | SNP-by-CpG Site Interactions in ABCA7 Are Associated with Cognition in Older African Americans.
Chaar DL, Nguyen K, Wang YZ, Ratliff SM, Mosley TH, Kardia SLR, Smith JA, Zhao W., Free PMC Article | 12/3/2022 |
| ATP-binding cassette protein ABCA7 deficiency impairs sphingomyelin synthesis, cognitive discrimination, and synaptic plasticity in the entorhinal cortex. | ATP-binding cassette protein ABCA7 deficiency impairs sphingomyelin synthesis, cognitive discrimination, and synaptic plasticity in the entorhinal cortex.
Iqbal J, Suarez MD, Yadav PK, Walsh MT, Li Y, Wu Y, Huang Z, James AW, Escobar V, Mokbe A, Brickman AM, Luchsinger JA, Dai K, Moreno H, Hussain MM., Free PMC Article | 11/12/2022 |
| Association between ABCA7 gene polymorphisms and Parkinson's disease susceptibility in a northern Chinese Han population. | Association between ABCA7 gene polymorphisms and Parkinson's disease susceptibility in a northern Chinese Han population.
Yang Z, Xue L, Li C, Li M, Xie A. | 07/16/2022 |
| ABCA7, a Genetic Risk Factor Associated with Alzheimer's Disease Risk in African Americans. | ABCA7, a Genetic Risk Factor Associated with Alzheimer's Disease Risk in African Americans.
Stepler KE, Gillyard TR, Reed CB, Avery TM, Davis JS, Robinson RAS., Free PMC Article | 04/16/2022 |
| Rare missense mutations in ABCA7 might increase Alzheimer's disease risk by plasma membrane exclusion. | Rare missense mutations in ABCA7 might increase Alzheimer's disease risk by plasma membrane exclusion.
Bossaerts L, Hendrickx Van de Craen E, Cacace R, Asselbergh B, Van Broeckhoven C., Free PMC Article | 04/9/2022 |
| Association Between Common Variants of APOE, ABCA7, A2M, BACE1, and Cerebrospinal Fluid Biomarkers in Alzheimer's Disease: Data from the PUMCH Dementia Cohort. | Association Between Common Variants of APOE, ABCA7, A2M, BACE1, and Cerebrospinal Fluid Biomarkers in Alzheimer's Disease: Data from the PUMCH Dementia Cohort.
Dong L, Mao C, Liu C, Li J, Huang X, Wang J, Lei D, Chu S, Sha L, Xu Q, Peng B, Cui L, Gao J., Free PMC Article | 03/5/2022 |
| Premature termination codon mutations in ABCA7 contribute to Alzheimer's disease risk in Belgian patients. | Premature termination codon mutations in ABCA7 contribute to Alzheimer's disease risk in Belgian patients.
Bossaerts L, Hens E, Hanseeuw B, Vandenberghe R, Cras P, De Deyn PP, Engelborghs S, Van Broeckhoven C, BELNEU Consortium. | 01/1/2022 |
| Role of ABCA7 in Human Health and in Alzheimer's Disease. | Role of ABCA7 in Human Health and in Alzheimer's Disease.
Dib S, Pahnke J, Gosselet F., Free PMC Article | 06/12/2021 |
| rs4147929 variant minor allele increases ABCA7 gene expression and ABCA7 shows increased gene expression in Alzheimer's disease patients compared with controls. | rs4147929 variant minor allele increases ABCA7 gene expression and ABCA7 shows increased gene expression in Alzheimer's disease patients compared with controls.
Liu G, Zhang H, Liu B, Wang T, Han Z, Ji X. | 06/12/2021 |
| Joint Effect of ABCA7 rs4147929 and Body Mass Index on Progression from Mild Cognitive Impairment to Alzheimer's Disease: The Shanghai Aging Study. | Joint Effect of ABCA7 rs4147929 and Body Mass Index on Progression from Mild Cognitive Impairment to Alzheimer's Disease: The Shanghai Aging Study.
Xi J, Ding D, Zhao Q, Liang X, Zheng L, Guo Q, Hong Z, Fu H, Xu J, Xiao Q. | 06/5/2021 |
| ABCA7 Genotype Moderates the Effect of Aerobic Exercise Intervention on Generalization of Prior Learning in Healthy Older African Americans. | ABCA7 Genotype Moderates the Effect of Aerobic Exercise Intervention on Generalization of Prior Learning in Healthy Older African Americans.
Sinha N, Berg CN, Shaw A, Gluck MA., Free PMC Article | 05/15/2021 |
| ABCA7 links sterol metabolism to the host defense system: Molecular background for potential management measure of Alzheimer's disease. | ABCA7 links sterol metabolism to the host defense system: Molecular background for potential management measure of Alzheimer's disease.
Abe-Dohmae S, Yokoyama S., Free PMC Article | 01/23/2021 |
| ABCA7 and EphA1 Genes Polymorphisms in Late-Onset Alzheimer's Disease. | ABCA7 and EphA1 Genes Polymorphisms in Late-Onset Alzheimer's Disease.
Talebi M, Delpak A, Khalaj-Kondori M, Sadigh-Eteghad S, Talebi M, Mehdizadeh E, Majdi A. | 11/21/2020 |
| ABCA7 polymorphisms correlate with memory impairment and default mode network in patients with APOEepsilon4-associated Alzheimer's disease. | ABCA7 polymorphisms correlate with memory impairment and default mode network in patients with APOEε4-associated Alzheimer's disease.
Chang YT, Hsu SW, Huang SH, Huang CW, Chang WN, Lien CY, Lee JJ, Lee CC, Chang CC., Free PMC Article | 08/13/2020 |
| ABCA7 is one of the most important risk genes of both early-onset and late-onset AD, harboring both common and rare risk variants with relatively large effect on AD risk. In European and African American populations, indirect ABCA7 GWAS associations are explained by expansion of an ABCA7 VNTR, and a common premature termination codon variant. A common ABCA7 missense variant may protect from disease. Review. | The role of ABCA7 in Alzheimer's disease: evidence from genomics, transcriptomics and methylomics.
De Roeck A, Van Broeckhoven C, Sleegers K., Free PMC Article | 07/25/2020 |
| In a case-control fMRI study of 36 healthy African Americans, we observed ABCA7 related impairments in behavioral generalization that was mediated by dissociation in entorhinal cortex resting state functional connectivity. | ABCA7 risk variant in healthy older African Americans is associated with a functionally isolated entorhinal cortex mediating deficient generalization of prior discrimination training.
Sinha N, Reagh ZM, Tustison NJ, Berg CN, Shaw A, Myers CE, Hill D, Yassa MA, Gluck MA., Free PMC Article | 06/6/2020 |
| Study observed strong association between VNTR length and a genome-wide associated signal for Alzheimer's disease (AD) in the ABCA7 locus. Expanded VNTR alleles were highly enriched in AD patients. VNTR length inversely correlated with amyloid beta1-42 in cerebrospinal fluid and ABCA7 expression. Also identified three novel ABCA7 alternative splicing events. | An intronic VNTR affects splicing of ABCA7 and increases risk of Alzheimer's disease.
De Roeck A, Duchateau L, Van Dongen J, Cacace R, Bjerke M, Van den Bossche T, Cras P, Vandenberghe R, De Deyn PP, Engelborghs S, Van Broeckhoven C, Sleegers K, BELNEU Consortium., Free PMC Article | 07/6/2019 |
| This study showed that ABCA7 genetic variants, especially the loss-of-function mutations, were significantly associated with the risk of Alzheimer's Disease. | Meta-Analysis of the Association between Variants in ABCA7 and Alzheimer's Disease.
Ma FC, Wang HF, Cao XP, Tan CC, Tan L, Yu JT. | 06/15/2019 |