| Identification and Functional Verification of CITED2 Gene Promoter Region in Patients with Patent Ductus Arteriosus. | Identification and Functional Verification of CITED2 Gene Promoter Region in Patients with Patent Ductus Arteriosus.
Chen Z, Chen HX, Hou HT, Yin XY, Yang Q, He GW., Free PMC Article | 11/29/2023 |
| CITED2 is a conserved regulator of the uterine-placental interface. | CITED2 is a conserved regulator of the uterine-placental interface.
Kuna M, Dhakal P, Iqbal K, Dominguez EM, Kent LN, Muto M, Moreno-Irusta A, Kozai K, Varberg KM, Okae H, Arima T, Sucov HM, Soares MJ., Free PMC Article | 01/14/2023 |
| CITED2 alleviates lipopolysaccharide-induced inflammation and pyroptosis in - human lung fibroblast by inhibition of NF-kappaB pathway. | CITED2 alleviates lipopolysaccharide-induced inflammation and pyroptosis in - human lung fibroblast by inhibition of NF-κB pathway.
Zhang X, Chen W, Liu W, Li D, Shen W. | 07/9/2022 |
| Downregulation of SUV39H1 and CITED2 Exerts Additive Effect on Promoting Adipogenic Commitment of Human Mesenchymal Stem Cells. | Downregulation of SUV39H1 and CITED2 Exerts Additive Effect on Promoting Adipogenic Commitment of Human Mesenchymal Stem Cells.
Tan L, Tran L, Ferreyra S, Moran JA, Skovgaard Z, Trujillo A, Ibili E, Zhao Y., Free PMC Article | 12/18/2021 |
| Genetic analysis of the CITED2 gene promoter in isolated and sporadic congenital ventricular septal defects. | Genetic analysis of the CITED2 gene promoter in isolated and sporadic congenital ventricular septal defects.
Zheng SQ, Chen HX, Liu XC, Yang Q, He GW., Free PMC Article | 09/25/2021 |
| A gain-of-function mutation in CITED2 is associated with congenital heart disease. | A gain-of-function mutation in CITED2 is associated with congenital heart disease.
Yadav ML, Jain D, Neelabh, Agrawal D, Kumar A, Mohapatra B. | 07/31/2021 |
| Bioinformatics assay results showed that these novel cited2 mutations alter the RNA folding, protein structure, and, therefore, probable effect on the protein function and may play a significant role in the development of congenital heart diseases | Novel Point Mutations of CITED2 Gene Are Associated with Non-familial Congenital Heart Disease (CHD) in Sporadic Pediatric Patients.
Dianatpour S, Khatami M, Heidari MM, Hadadzadeh M. | 04/4/2020 |
| GINS2 plays an important role in cell proliferation and apoptosis of thyroid cancer by regulating the expressions of CITED2 and LOXL2, which may be a potential biomarker for diagnosis or prognosis and a drug target for therapy. | GINS2 promotes cell proliferation and inhibits cell apoptosis in thyroid cancer by regulating CITED2 and LOXL2.
Ye Y, Song YN, He SF, Zhuang JH, Wang GY, Xia W. | 04/4/2020 |
| These findings illustrate that combined PU.1/CITED2 deregulation induces a transcriptional program that promotes HSPC maintenance, which might be a prerequisite for malignant transformation. | Transcriptional regulators CITED2 and PU.1 cooperate in maintaining hematopoietic stem cells.
Mattes K, Geugien M, Korthuis PM, Brouwers-Vos AZ, Fehrmann RSN, Todorova TI, Steidl U, Vellenga E, Schepers H. | 02/22/2020 |
| tested the hypothesis that CITED2 mediates cross-talk between IL-4 signaling and mechanical loading-induced pathways that result in chondroprotection, at least in part, by downregulating MMP13 | CITED2 mediates the cross-talk between mechanical loading and IL-4 to promote chondroprotection.
He Z, Leong DJ, Xu L, Hardin JA, Majeska RJ, Schaffler MB, Thi MM, Yang L, Goldring MB, Cobelli NJ, Sun HB., Free PMC Article | 02/15/2020 |
| The results showed that the core promoter area of MUC5AC was located within the 935/+48 region and that P300 reduced the expression of MUC5AC in A549 cells. | Characterization of the human mucin 5AC promoter and its regulation by the histone acetyltransferase P300.
Xu S, Hui Y, Shu J, Qian J, Li L., Free PMC Article | 05/25/2019 |
| Observations identify CITED2 as a novel negative regulator of macrophage proinflammatory activation that protects the host from inflammatory insults. | CITED2 Restrains Proinflammatory Macrophage Activation and Response.
Kim GD, Das R, Rao X, Zhong J, Deiuliis JA, Ramirez-Bergeron DL, Rajagopalan S, Mahabeleshwar GH., Free PMC Article | 04/6/2019 |
| CITED2 acts as a molecular chaperone to guide PRMT5 and p300 to nucleolin, thereby activating nucleolin. Informatics and experimental data suggest that the CITED2-nucleolin axis is involved in prostate cancer metastasis. | Aberrant expression of CITED2 promotes prostate cancer metastasis by activating the nucleolin-AKT pathway.
Shin SH, Lee GY, Lee M, Kang J, Shin HW, Chun YS, Park JW., Free PMC Article | 01/19/2019 |
| Knockdown of CITED2 led to a decreased interaction of p53 with its inhibitor MDM2, which results in increased amounts of total p53 protein. Data indicate that CITED2 functions in pathways regulating p53 activity. | CITED2 affects leukemic cell survival by interfering with p53 activation.
Mattes K, Berger G, Geugien M, Vellenga E, Schepers H., Free PMC Article | 07/7/2018 |
| CITED2 regulates primary breast tumor growth, likely by influencing tumor vasculature via TGF-beta-dependent regulation of VEGFA. | Down-regulation of CITED2 attenuates breast tumor growth, vessel formation and TGF-β-induced expression of VEGFA.
Jayaraman S, Doucet M, Kominsky SL., Free PMC Article | 02/24/2018 |
| The results suggest that CITED2 mutations in conserved regions lead to disease-causing biological and functional changes and may contribute to the occurrence of conotruncal heart defects in Chinese children. | CITED2 Mutations in Conserved Regions Contribute to Conotruncal Heart Defects in Chinese Children.
Li B, Pu T, Liu Y, Xu Y, Xu R. | 09/23/2017 |
| CITED2 gene mutation may play a significant role in the development of pediatric congenital heart disease. | Functional Analyses of a Novel CITED2 Nonsynonymous Mutation in Chinese Tibetan Patients with Congenital Heart Disease.
Liu S, Su Z, Tan S, Ni B, Pan H, Liu B, Wang J, Xiao J, Chen Q. | 09/16/2017 |
| CITED2 supports gastric cancer cell colony formation and proliferation while inhibiting apoptosis making it a potential gene therapy target for gastric cancer. | Knockdown of Cbp/P300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2 inhibits cell division and increases apoptosis in gastric cancer.
Tang Z, He G, Xu J, Zhongfu L. | 09/2/2017 |
| Through allosteric enhancement of HIF-1alpha release, CITED2 activates a highly responsive negative feedback circuit that rapidly and efficiently attenuates the hypoxic response, even at modest CITED2 concentrations. | Hypersensitive termination of the hypoxic response by a disordered protein switch.
Berlow RB, Dyson HJ, Wright PE., Free PMC Article | 08/19/2017 |
| down-regulation of Cited2 was associated with high glucose-induced apoptosis in cardiomyocytes in vitro | Cited2 participates in cardiomyocyte apoptosis and maternal diabetes-induced congenital heart abnormality.
Su D, Song JX, Gao Q, Guan L, Li Q, Shi C, Ma X. | 06/3/2017 |
| High Cited2 level in cumulus cells was associated with low embryo quality and pregnancy outcome in in vitro fertilization patients. | Cited2 protein level in cumulus cells is a biomarker for human embryo quality and pregnancy outcome in one in vitro fertilization cycle.
Fang Y, Shang W, Wei DL, Zeng SM. | 05/27/2017 |
| the downregulation of CITED2 contributes to TGFbeta-mediated senescence. | Downregulation of CITED2 contributes to TGFβ-mediated senescence of tendon-derived stem cells.
Hu C, Zhang Y, Tang K, Luo Y, Liu Y, Chen W. | 05/20/2017 |
| CITED2 plays important roles in the progression and chemoresistance of breast carcinoma and that CITED2 status is a potent prognostic factor in breast cancer patients. | CITED2 in breast carcinoma as a potent prognostic predictor associated with proliferation, migration and chemoresistance.
Minemura H, Takagi K, Sato A, Takahashi H, Miki Y, Shibahara Y, Watanabe M, Ishida T, Sasano H, Suzuki T., Free PMC Article | 02/18/2017 |
| Intrinsic protein disorder plays a prominent role in the function and interactions of the transcriptional co-activators CBP and p300. (Review) | Role of Intrinsic Protein Disorder in the Function and Interactions of the Transcriptional Coactivators CREB-binding Protein (CBP) and p300.
Dyson HJ, Wright PE., Free PMC Article | 08/6/2016 |
| FBXL5-mediated degradation of CITED2 leads to the activation of HIF-1 alpha. | FBXL5 modulates HIF-1α transcriptional activity by degradation of CITED2.
Machado-Oliveira G, Guerreiro E, Matias AC, Facucho-Oliveira J, Pacheco-Leyva I, Bragança J. | 08/15/2015 |