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    TUBB3 tubulin beta 3 class III [ Homo sapiens (human) ]

    Gene ID: 10381, updated on 28-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    NOTCH3 promotes docetaxel resistance of prostate cancer cells through regulating TUBB3 and MAPK signaling pathway.

    NOTCH3 promotes docetaxel resistance of prostate cancer cells through regulating TUBB3 and MAPK signaling pathway.
    Sun X, Zhang Y, Xin S, Jin L, Cao Q, Wang H, Wang K, Liu X, Tang C, Li W, Li Z, Wen X, Yang G, Guo C, Liu Z, Ye L., Free PMC Article

    02/16/2024
    OSGIN1 is a novel TUBB3 regulator that promotes tumor progression and gefitinib resistance in non-small cell lung cancer.

    OSGIN1 is a novel TUBB3 regulator that promotes tumor progression and gefitinib resistance in non-small cell lung cancer.
    Xie X, Laster KV, Li J, Nie W, Yi YW, Liu K, Seong YS, Dong Z, Kim DJ., Free PMC Article

    09/6/2023
    Tubb3 expression levels are sensitive to neuronal activity changes and determine microtubule growth and kinesin-mediated transport.

    Tubb3 expression levels are sensitive to neuronal activity changes and determine microtubule growth and kinesin-mediated transport.
    Radwitz J, Hausrat TJ, Heisler FF, Janiesch PC, Pechmann Y, Rübhausen M, Kneussel M., Free PMC Article

    11/5/2022
    Infantile esotropia in a family with TUBB3 mutation associated congenital fibrosis of extraocular muscles.

    Infantile esotropia in a family with TUBB3 mutation associated congenital fibrosis of extraocular muscles.
    Jang Y, Kwak E, An JY, Jung JH.

    10/29/2022
    Exosomal TUBB3 mRNA expression of metastatic castration-resistant prostate cancer patients: Association with patient outcome under abiraterone.

    Exosomal TUBB3 mRNA expression of metastatic castration-resistant prostate cancer patients: Association with patient outcome under abiraterone.
    Zhu S, Ni Y, Sun G, Wang Z, Chen J, Zhang X, Zhao J, Zhu X, Dai J, Liu Z, Liang J, Zhang H, Zhang Y, Shen P, Zeng H., Free PMC Article

    02/26/2022
    Airway basal stem cells generate distinct subpopulations of PNECs.

    Airway basal stem cells generate distinct subpopulations of PNECs.
    Mou H, Yang Y, Riehs MA, Barrios J, Shivaraju M, Haber AL, Montoro DT, Gilmore K, Haas EA, Paunovic B, Rajagopal J, Vargas SO, Haynes RL, Fine A, Cardoso WV, Ai X., Free PMC Article

    02/19/2022
    TUBB3 Arg262His causes a recognizable syndrome including CFEOM3, facial palsy, joint contractures, and early-onset peripheral neuropathy.

    TUBB3 Arg262His causes a recognizable syndrome including CFEOM3, facial palsy, joint contractures, and early-onset peripheral neuropathy.
    Whitman MC, Barry BJ, Robson CD, Facio FM, Van Ryzin C, Chan WM, Lehky TJ, Thurm A, Zalewski C, King KA, Brewer C, Almpani K, Lee JS, Delaney A, FitzGibbon EJ, Lee PR, Toro C, Paul SM, Abdul-Rahman OA, Webb BD, Jabs EW, Moller HU, Larsen DA, Antony JH, Troedson C, Ma A, Ragnhild G, Wirgenes KV, Tham E, Kvarnung M, Maarup TJ, MacKinnon S, Hunter DG, Collins FS, Manoli I, Engle EC., Free PMC Article

    11/13/2021
    TUBB3 M323V Syndrome Presents with Infantile Nystagmus.

    TUBB3 M323V Syndrome Presents with Infantile Nystagmus.
    Jin S, Park SE, Won D, Lee ST, Han SH, Han J., Free PMC Article

    08/14/2021
    miR-200b-3p mitigates oxaliplatin resistance via targeting TUBB3 in colorectal cancer.

    miR-200b-3p mitigates oxaliplatin resistance via targeting TUBB3 in colorectal cancer.
    Wu YZ, Lin HY, Zhang Y, Chen WF.

    07/24/2021
    The recurrent TUBB3 Gly98Ser substitution is the first described to inconsistently result in CFEOM3.

    The recurrent TUBB3 Gly98Ser substitution is the first described to inconsistently result in CFEOM3.
    Smith SC, Olney AH, Beavers A, Spaulding J, Nelson M, Nielsen S, Sanmann JN.

    06/12/2021
    TUBB3 E410K syndrome: Case report and review of the clinical spectrum of TUBB3 mutations.

    TUBB3 E410K syndrome: Case report and review of the clinical spectrum of TUBB3 mutations.
    Dentici ML, Maglione V, Agolini E, Catena G, Capolino R, Lanari V, Novelli A, Sinibaldi L, Vecchio D, Gonfiantini MV, Macchiaiolo M, Digilio MC, Dallapiccola B, Bartuli A.

    06/5/2021
    Association of high TUBB3 with resistance to adjuvant docetaxel-based chemotherapy in gastric cancer: translational study of ITACA-S.

    Association of high TUBB3 with resistance to adjuvant docetaxel-based chemotherapy in gastric cancer: translational study of ITACA-S.
    Di Bartolomeo M, Raimondi A, Cecchi F, Catenacci DVT, Schwartz S, Sellappan S, Tian Y, Miceli R, Pellegrinelli A, Giommoni E, Aitini E, Spada F, Rosati G, Marchet A, Pucci F, Zaniboni A, Tamberi S, Pressiani T, Sanna G, Cantore M, Mosconi S, Bolzoni P, Pinto C, Landi L, Soto Parra HJ, Cavanna L, Corallo S, Martinetti A, Hembrough TA, Pietrantonio F.

    04/24/2021
    TUBB3 Promotes Growth and Invasion of Gallbladder Cancer Cells by Akt/mTOR Signal Pathway.

    TUBB3 Promotes Growth and Invasion of Gallbladder Cancer Cells by Akt/mTOR Signal Pathway.
    Liu Z, Li S, Dong J, Miao Y.

    04/13/2021
    Outcomes of strabismus surgery in genetically confirmed congenital fibrosis of the extraocular muscles.

    Outcomes of strabismus surgery in genetically confirmed congenital fibrosis of the extraocular muscles.
    Heidary G, Mackinnon S, Elliott A, Barry BJ, Engle EC, Hunter DG., Free PMC Article

    04/13/2021
    Exosomal miR-200c suppresses chemoresistance of docetaxel in tongue squamous cell carcinoma by suppressing TUBB3 and PPP2R1B.

    Exosomal miR-200c suppresses chemoresistance of docetaxel in tongue squamous cell carcinoma by suppressing TUBB3 and PPP2R1B.
    Cui J, Wang H, Zhang X, Sun X, Zhang J, Ma J., Free PMC Article

    03/27/2021
    Beta3-Tubulin is Critical for Microtubule Dynamics, Cell Cycle Regulation, and Spontaneous Release of Microvesicles in Human Malignant Melanoma Cells (A375).

    Beta3-Tubulin is Critical for Microtubule Dynamics, Cell Cycle Regulation, and Spontaneous Release of Microvesicles in Human Malignant Melanoma Cells (A375).
    Altonsy MO, Ganguly A, Amrein M, Surmanowicz P, Li SS, Lauzon GJ, Mydlarski PR., Free PMC Article

    11/28/2020
    Congenital monocular elevation deficiency associated with a novel TUBB3 gene variant.

    Congenital monocular elevation deficiency associated with a novel TUBB3 gene variant.
    Thomas MG, Maconachie GDE, Constantinescu CS, Chan WM, Barry B, Hisaund M, Sheth V, Kuht HJ, Dineen RA, Harieaswar S, Engle EC, Gottlob I., Free PMC Article

    10/31/2020
    TUBB3 Is Associated with High-Grade Histology, Poor Prognosis, p53 Expression, and Cancer Stem Cell Markers in Clear Cell Renal Cell Carcinoma.

    TUBB3 Is Associated with High-Grade Histology, Poor Prognosis, p53 Expression, and Cancer Stem Cell Markers in Clear Cell Renal Cell Carcinoma.
    Sekino Y, Han X, Babasaki T, Miyamoto S, Kitano H, Kobayashi G, Goto K, Inoue S, Hayashi T, Teishima J, Sakamoto N, Sentani K, Oue N, Yasui W, Matsubara A.

    10/24/2020
    Autosomal dominant TUBB3-related syndrome: Fetal, radiologic, clinical and morphological features.

    Autosomal dominant TUBB3-related syndrome: Fetal, radiologic, clinical and morphological features.
    Blumkin L, Leibovitz Z, Krajden-Haratz K, Arad A, Yosovich K, Gindes L, Zerem A, Ben-Sira L, Lev D, Nissenkorn A, Kidron D, Dobyns WB, Malinger G, Bahi-Buisson N, Leventer RJ, Lerman-Sagie T.

    10/24/2020
    LncRNA RPPH1 promotes colorectal cancer metastasis by interacting with TUBB3 and by promoting exosomes-mediated macrophage M2 polarization.

    LncRNA RPPH1 promotes colorectal cancer metastasis by interacting with TUBB3 and by promoting exosomes-mediated macrophage M2 polarization.
    Liang ZX, Liu HS, Wang FW, Xiong L, Zhou C, Hu T, He XW, Wu XJ, Xie D, Wu XR, Lan P., Free PMC Article

    08/22/2020
    The median OS for patients with a high beta III-tubulin expression was 17.4 (95% CI 8.7-21.0) months vs. 19.8 (95% CI 16.6-23.6) months for patients with a low expression (p = 0.039). Our results show that a high beta III-tubulin expression is a negative prognostic factor in metastatic castration-resistant prostate cancer patients treated with docetaxel.

    Class III β-tubulin expression as a predictor of docetaxel-resistance in metastatic castration-resistant prostate cancer.
    Maahs L, Sanchez BE, Gupta N, Van Harn M, Barrack ER, Reddy PV, Hwang C., Free PMC Article

    03/14/2020
    Human TUBB3 mutations specifically perturb netrin-1/UNC5C-mediated repulsion.

    Disease-associated mutations in human TUBB3 disturb netrin repulsive signaling.
    Shao Q, Yang T, Huang H, Majumder T, Khot BA, Khouzani MM, Alarmanazi F, Gore YK, Liu G., Free PMC Article

    03/7/2020
    ALDH1A1 knockdown study showed that tubulin beta III (TUBB3) was one of the downregulated genes in PDCs.

    ALDH1A1 in patient-derived bladder cancer spheroids activates retinoic acid signaling leading to TUBB3 overexpression and tumor progression.
    Namekawa T, Ikeda K, Horie-Inoue K, Suzuki T, Okamoto K, Ichikawa T, Yano A, Kawakami S, Inoue S.

    02/22/2020
    The expression levels of TUBB3, ERCC1 and P-gp in ovarian cancer tissues were significantly higher than those in adjacent normal tissues (p<0.05).

    Expression levels of TUBB3, ERCC1 and P-gp in ovarian cancer tissues and adjacent normal tissues and their clinical significance.
    Jia Y, Sun S, Gao X, Cui X.

    09/28/2019
    Invasive colon cancer cells regulate endothelial-to-mesenchymal transition of endothelium via tubulin-beta3 upregulation and its phosphorylation.

    Invasive Colon Cancer Cells Induce Transdifferentiation of Endothelium to Cancer-Associated Fibroblasts through Microtubules Enriched in Tubulin-β3.
    Wawro ME, Chojnacka K, Wieczorek-Szukała K, Sobierajska K, Niewiarowska J., Free PMC Article

    07/13/2019
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