| EPAC1 enhances brown fat growth and beige adipogenesis. | EPAC1 enhances brown fat growth and beige adipogenesis.
Reverte-Salisa L, Siddig S, Hildebrand S, Yao X, Zurkovic J, Jaeckstein MY, Heeren J, Lezoualc'h F, Krahmer N, Pfeifer A., Free PMC Article | 01/29/2024 |
| Cyclic AMP induces reversible EPAC1 condensates that regulate histone transcription. | Cyclic AMP induces reversible EPAC1 condensates that regulate histone transcription.
Iannucci LF, D'Erchia AM, Picardi E, Bettio D, Conca F, Surdo NC, Di Benedetto G, Musso D, Arrigoni C, Lolicato M, Vismara M, Grisan F, Salviati L, Milanesi L, Pesole G, Lefkimmiatis K., Free PMC Article | 09/11/2023 |
| EPAC Regulates Melanoma Growth by Stimulating mTORC1 Signaling and Loss of EPAC Signaling Dependence Correlates with Melanoma Progression. | EPAC Regulates Melanoma Growth by Stimulating mTORC1 Signaling and Loss of EPAC Signaling Dependence Correlates with Melanoma Progression.
Krishnan A, Bhasker AI, Singh MK, Rodriguez CI, Pérez EC, Altameemi S, Lares M, Khan H, Ndiaye M, Ahmad N, Schieke SM, Setaluri V., Free PMC Article | 10/15/2022 |
| Absence of EPAC1 Signaling to Stabilize CFTR in Intestinal Organoids. | Absence of EPAC1 Signaling to Stabilize CFTR in Intestinal Organoids.
Ferreira JF, Silva IAL, Botelho HM, Amaral MD, Farinha CM., Free PMC Article | 08/6/2022 |
| Origin and Isoform Specific Functions of Exchange Proteins Directly Activated by cAMP: A Phylogenetic Analysis. | Origin and Isoform Specific Functions of Exchange Proteins Directly Activated by cAMP: A Phylogenetic Analysis.
Ni Z, Cheng X., Free PMC Article | 12/4/2021 |
| Identification and Characterization of an Affimer Affinity Reagent for the Detection of the cAMP Sensor, EPAC1. | Identification and Characterization of an Affimer Affinity Reagent for the Detection of the cAMP Sensor, EPAC1.
Buist HK, Luchowska-Stańska U, van Basten B, Valli J, Smith BO, Baillie GS, Rickman C, Ricketts B, Davidson A, Hannam R, Sunderland J, Yarwood SJ., Free PMC Article | 11/22/2021 |
| Epac: new emerging cAMP-binding protein. | Epac: new emerging cAMP-binding protein.
Lee K., Free PMC Article | 10/16/2021 |
| Multiple Rap1 effectors control Epac1-mediated tightening of endothelial junctions. | Multiple Rap1 effectors control Epac1-mediated tightening of endothelial junctions.
Pannekoek WJ, Vliem MJ, Bos JL., Free PMC Article | 07/17/2021 |
| GRKs and Epac1 Interaction in Cardiac Remodeling and Heart Failure. | GRKs and Epac1 Interaction in Cardiac Remodeling and Heart Failure.
Laudette M, Formoso K, Lezoualc'h F., Free PMC Article | 06/26/2021 |
| MRP4/ABCC4 expression is regulated by histamine in acute myeloid leukemia cells, determining cAMP efflux. | MRP4/ABCC4 expression is regulated by histamine in acute myeloid leukemia cells, determining cAMP efflux.
Rodríguez González A, Sahores A, Díaz-Nebreda A, Yaneff A, Di Siervi N, Gómez N, Monczor F, Fernández N, Davio C, Shayo C. | 06/19/2021 |
| LSM12-EPAC1 defines a neuroprotective pathway that sustains the nucleocytoplasmic RAN gradient. | LSM12-EPAC1 defines a neuroprotective pathway that sustains the nucleocytoplasmic RAN gradient.
Lee J, Park J, Kim JH, Lee G, Park TE, Yoon KJ, Kim YK, Lim C., Free PMC Article | 02/6/2021 |
| Downregulation of Epac Reduces Fibrosis and Induces Apoptosis Through Akt Signaling in Human Keloid Fibroblasts. | Downregulation of Epac Reduces Fibrosis and Induces Apoptosis Through Akt Signaling in Human Keloid Fibroblasts.
Lv W, Liu S, Zhang Q, Yi Z, Bao X, Feng Y, Ren Y. | 01/9/2021 |
| Dysfunctional EAT thickness may promote maladaptive heart remodeling in CVD patients through the ST2-IL33 system, directly related to EPAC protein expression. | Dysfunctional EAT thickness may promote maladaptive heart remodeling in CVD patients through the ST2-IL33 system, directly related to EPAC protein expression.
Vianello E, Dozio E, Bandera F, Schmitz G, Nebuloni M, Longhi E, Tacchini L, Guazzi M, Corsi Romanelli MM., Free PMC Article | 10/24/2020 |
| Conformational States of Exchange Protein Directly Activated by cAMP (EPAC1) Revealed by Ensemble Modeling and Integrative Structural Biology. | Conformational States of Exchange Protein Directly Activated by cAMP (EPAC1) Revealed by Ensemble Modeling and Integrative Structural Biology.
White MA, Tsalkova T, Mei FC, Cheng X., Free PMC Article | 09/19/2020 |
| Coxiella burnetii is a Gram negative bacterium that survives and grows in a large Coxiella replicative vacuole (CRV), which displays lysosomal and autophagic features. This report presents evidence that both, EPAC and its downstream effector Rap2b, were recruited to the CRV. | The cAMP effectors, Rap2b and EPAC, are involved in the regulation of the development of the Coxiella burnetii containing vacuole by altering the fusogenic capacity of the vacuole.
Mansilla Pareja ME, Gaurón MC, Robledo E, Aguilera MO, Colombo MI., Free PMC Article | 11/23/2019 |
| The enhancing effect of mt-cAMP on Ca(2+) uptake was independent from both the mitochondrial membrane potential and Ca(2+) efflux, but was reduced by Epac1 blockade both in intact and in permeabilized cells. | Mitochondrial cAMP exerts positive feedback on mitochondrial Ca(2+) uptake via the recruitment of Epac1.
Szanda G, Wisniewski É, Rajki A, Spät A. | 11/2/2019 |
| PDE4 and Epac1 expression levels are increased in rectal carcinoma tissues, suggesting that the two proteins may be involved in the development of this malignancy. Meanwhile, correlations between PDE4 and Epac1, PDE4 and Cx43, PDE4 and cyclin E1, and Epac1 and Cx43 suggested synergistic effects of these proteins in promoting rectal carcinoma. | PDE4 and Epac1 Synergistically Promote Rectal Carcinoma via the cAMP Pathway.
Kong X, Ai G, Wang D, Chen R, Guo D, Yao Y, Wang K, Liang G, Qi F, Liu W, Zhang Y., Free PMC Article | 08/31/2019 |
| EPAC1 supports triple negative breast cancer-induced angiogenesis, tumor cell migration and invasiveness as well as pro-metastatic phenotypes in endothelial cells induced through the tumor secretome | cAMP regulated EPAC1 supports microvascular density, angiogenic and metastatic properties in a model of triple negative breast cancer.
Kumar N, Prasad P, Jash E, Jayasundar S, Singh I, Alam N, Murmu N, Somashekhar SP, Goldman A, Sehrawat S., Free PMC Article | 04/27/2019 |
| Through isoform-specific gene knockdown, the authors found that EPAC2, but not EPAC1, plays a dominant role in controlling RSV replication and virus-induced host responses. | Exchange Proteins Directly Activated by cAMP and Their Roles in Respiratory Syncytial Virus Infection.
Choi EJ, Ren Y, Chen Y, Liu S, Wu W, Ren J, Wang P, Garofalo RP, Zhou J, Bao X., Free PMC Article | 03/30/2019 |
| Epac1 can restore normal insulin signaling in the retinal vasculature through reductions in inflammatory cytokines | Epac1 Restores Normal Insulin Signaling through a Reduction in Inflammatory Cytokines.
Curtiss E, Jiang Y, Liu L, Hawthorne C, Zhang J, Steinle JJ., Free PMC Article | 12/22/2018 |
| EPAC1inhibits AnxA2 surface translocation and plasminogen activation via PLCepsilon-PKC pathway. | EPAC1 regulates endothelial annexin A2 cell surface translocation and plasminogen activation.
Yang W, Mei FC, Cheng X., Free PMC Article | 12/22/2018 |
| Cyclic AMP (cAMP), a secondary messenger responsible for various physiological processes regulates cell metabolism by activating Protein kinase A (PKA) and by targeting exchange protein directly activated by cAMP (EPAC). EPAC is present in two isoforms EPAC1 and EPAC2, which exhibit different tissue distribution and is involved in GDP/GTP exchange along with activating Rap1- and Rap2-mediated signaling pathways. | Insights into exchange factor directly activated by cAMP (EPAC) as potential target for cancer treatment.
Kumar N, Prasad P, Jash E, Saini M, Husain A, Goldman A, Sehrawat S. | 11/3/2018 |
| These data reveal a MAPK pathway-independent switch in response to cAMP signaling during melanoma progression.Implications: The prosurvival mechanism involving the cAMP-EPAC-RAP1 signaling pathway suggest the potential for new targeted therapies in melanoma. | EPAC-RAP1 Axis-Mediated Switch in the Response of Primary and Metastatic Melanoma to Cyclic AMP.
Rodríguez CI, Castro-Pérez E, Prabhakar K, Block L, Longley BJ, Wisinski JA, Kimple ME, Setaluri V., Free PMC Article | 07/14/2018 |
| Authors show that blockade of cAMP signaling using MDL12330A led to an increase in PUMA transcript levels, but not p21 in melanoma cells. Results suggest that transcriptional repression is one of the functions of the cAMP-Epac signaling pathway. | Cyclic AMP-Epac signaling pathway contributes to repression of PUMA transcription in melanoma cells.
Lakhter AJ, Naidu SR. | 05/26/2018 |
| Results show that Epac1 binds to importin beta1 which prevents its accumulation in plasma membrane and, uncover a cAMP-independent function of Epac1 at the plasma membrane in the regulation of neurite outgrowth. | Epac1 interacts with importin β1 and controls neurite outgrowth independently of cAMP and Rap1.
Baameur F, Singhmar P, Zhou Y, Hancock JF, Cheng X, Heijnen CJ, Kavelaars A., Free PMC Article | 05/19/2018 |