| A conserved but structurally divergent loop in acyl protein thioesterase 1 regulates its catalytic activity, ligand binding, and folded stability. | A conserved but structurally divergent loop in acyl protein thioesterase 1 regulates its catalytic activity, ligand binding, and folded stability.
Harris WT 3rd, Altieri I, Gieck I, Johnson RJ. | 05/22/2024 |
| Depalmitoylation and cell physiology: APT1 as a mediator of metabolic signals. | Depalmitoylation and cell physiology: APT1 as a mediator of metabolic signals.
Speck SL, Wei X, Semenkovich CF., | 03/13/2024 |
| LncRNA LOXL1-AS1 Facilitates the Oncogenic Character in Cervical Cancer by the miR-526b-5p /LYPLA1 Axis. | LncRNA LOXL1-AS1 Facilitates the Oncogenic Character in Cervical Cancer by the miR-526b-5p /LYPLA1 Axis.
Zhang Y, Zheng M, Zhang L, Yuan P, Zhou J, Wang Y, Wang H. | 07/16/2022 |
| LYPLA1 and LYPLA2 are each able to account for the loss of the other to maintain lipid homeostasis in cells | Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling.
Wepy JA, Galligan JJ, Kingsley PJ, Xu S, Goodman MC, Tallman KA, Rouzer CA, Marnett LJ., Free PMC Article | 02/15/2020 |
| The depalmitoylating enzyme acyl-protein thioesterase 1 (APT1) directs the asymmetric localization of Numb and beta-catenin in MDA-MB-231 triple receptor-negative breast cancer cells. | The depalmitoylase APT1 directs the asymmetric partitioning of Notch and Wnt signaling during cell division.
Stypulkowski E, Asangani IA, Witze ES., Free PMC Article | 05/11/2019 |
| Study results suggest that the LYPLA1 gene plays a tumorpromotor role in nonsmall cell lung cancer cells in vitro. | Inhibition of cell proliferation and migration in non‑small cell lung cancer cells through the suppression of LYPLA1.
Mohammed A, Zhang C, Zhang S, Shen Q, Li J, Tang Z, Liu H. | 02/9/2019 |
| Data show taht active S-depalmitoylation in mitochondria, in part mediated by acyl-protein thioesterase 1 (APT1) | Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes.
Kathayat RS, Cao Y, Elvira PD, Sandoz PA, Zaballa ME, Springer MZ, Drake LE, Macleod KF, van der Goot FG, Dickinson BC., Free PMC Article | 03/10/2018 |
| Here, we describe the conserved functions of APT1 and APT2 across organisms and discuss the possibility that these enzymes are members of a larger family of depalmitoylation enzymes. | Enzymatic protein depalmitoylation by acyl protein thioesterases.
Lin DT, Conibear E. | 01/2/2016 |
| High expression of APT1 is associated with chronic lymphocytic leukemia. | miRs-138 and -424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in CLL.
Berg V, Rusch M, Vartak N, Jüngst C, Schauss A, Waldmann H, Hedberg C, Pallasch CP, Bastiaens PI, Hallek M, Wendtner CM, Frenzel LP., Free PMC Article | 07/25/2015 |
| identifcation APT1 as one of the thioesterases in the acylation cycle and demonstration that this protein is a cellular target of the inhibitor. | Small-molecule inhibition of APT1 affects Ras localization and signaling.
Dekker FJ, Rocks O, Vartak N, Menninger S, Hedberg C, Balamurugan R, Wetzel S, Renner S, Gerauer M, Schölermann B, Rusch M, Kramer JW, Rauh D, Coates GW, Brunsveld L, Bastiaens PI, Waldmann H. | 07/18/2013 |
| Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product and growth-associated protein-43 | Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product and growth-associated protein-43.
Kong E, Peng S, Chandra G, Sarkar C, Zhang Z, Bagh MB, Mukherjee AB., Free PMC Article | 06/1/2013 |
| Serum activity of APT1 may play an important role in determination of the concentration of des-acyl ghrelin in circulation, especially under septic inflammation. | Identification and characterization of acyl-protein thioesterase 1/lysophospholipase I as a ghrelin deacylation/lysophospholipid hydrolyzing enzyme in fetal bovine serum and conditioned medium.
Satou M, Nishi Y, Yoh J, Hattori Y, Sugimoto H. | 11/6/2010 |
| Endogenous and overexpressed hAPT1 were mainly localized in the cytosol, while some signals were detected in the plasma membrane, the nuclear membrane and endoplasmic reticulum in HEK293 cells. | Thioesterase activity and subcellular localization of acylprotein thioesterase 1/lysophospholipase 1.
Hirano T, Kishi M, Sugimoto H, Taguchi R, Obinata H, Ohshima N, Tatei K, Izumi T. | 01/21/2010 |
| Results suggest that APT1-regulated depalmitoylation of Galpha(13) might be an important downstream event of miR-138 function. | A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis.
Siegel G, Obernosterer G, Fiore R, Oehmen M, Bicker S, Christensen M, Khudayberdiev S, Leuschner PF, Busch CJ, Kane C, Hübel K, Dekker F, Hedberg C, Rengarajan B, Drepper C, Waldmann H, Kauppinen S, Greenberg ME, Draguhn A, Rehmsmeier M, Martinez J, Schratt GM., Free PMC Article | 01/21/2010 |