| FAM3C in Cancer-Associated Adipocytes Promotes Breast Cancer Cell Survival and Metastasis. | FAM3C in Cancer-Associated Adipocytes Promotes Breast Cancer Cell Survival and Metastasis.
Kim S, Oh J, Park C, Kim M, Jo W, Kim CS, Cho SW, Park J. | 02/22/2024 |
| FAM3C in circulating tumor-derived extracellular vesicles promotes non-small cell lung cancer growth in secondary sites. | FAM3C in circulating tumor-derived extracellular vesicles promotes non-small cell lung cancer growth in secondary sites.
Thuya WL, Kong LR, Syn NL, Ding LW, Cheow ESH, Wong RTX, Wang T, Goh RMW, Song H, Jayasinghe MK, Le MT, Hu JC, Yong WP, Lee SC, Wong AL, Sethi G, Hung HT, Ho PC, Thiery JP, Sze SK, Guo T, Soo RA, Yang H, Lim YC, Wang L, Goh BC., Free PMC Article | 02/15/2023 |
| Transcriptional downregulation of FAM3C/ILEI in the Alzheimer's brain. | Transcriptional downregulation of FAM3C/ILEI in the Alzheimer's brain.
Watanabe N, Nakano M, Mitsuishi Y, Hara N, Mano T, Iwata A, Murayama S, Suzuki T, Ikeuchi T, Nishimura M. | 04/16/2022 |
| Genetic variants in the FAM3C gene are associated with lipid traits in Chinese children. | Genetic variants in the FAM3C gene are associated with lipid traits in Chinese children.
Song Q, Song J, Li C, Wang Y, Qi L, Wang H. | 01/15/2022 |
| DEAH-box polypeptide 32 promotes hepatocellular carcinoma progression via activating the beta-catenin pathway. | DEAH-box polypeptide 32 promotes hepatocellular carcinoma progression via activating the β-catenin pathway.
Hu X, Yuan G, Li Q, Huang J, Cheng X, Chen J., Free PMC Article | 12/4/2021 |
| The FAM3C locus that encodes interleukin-like EMT inducer (ILEI) is frequently co-amplified in MET-amplified cancers and contributes to invasiveness. | The FAM3C locus that encodes interleukin-like EMT inducer (ILEI) is frequently co-amplified in MET-amplified cancers and contributes to invasiveness.
Schmidt U, Heller G, Timelthaler G, Heffeter P, Somodi Z, Schweifer N, Sibilia M, Berger W, Csiszar A., Free PMC Article | 10/23/2021 |
| Extracellular Release of ILEI/FAM3C and Amyloid-beta Is Associated with the Activation of Distinct Synapse Subpopulations. | Extracellular Release of ILEI/FAM3C and Amyloid-β Is Associated with the Activation of Distinct Synapse Subpopulations.
Nakano M, Mitsuishi Y, Liu L, Watanabe N, Hibino E, Hata S, Saito T, Saido TC, Murayama S, Kasuga K, Ikeuchi T, Suzuki T, Nishimura M. | 09/18/2021 |
| miR-574-3p inhibits proliferation and invasion in esophageal cancer by targeting FAM3C and MAPK1. | miR-574-3p inhibits proliferation and invasion in esophageal cancer by targeting FAM3C and MAPK1.
Jin LL, Zhang SJ, Lu GX, Lv F, Shang R, Yang J. | 07/31/2021 |
| FAM3C-YY1-HSF1 pathway plays an important role in TGFbeta-triggered proliferation and migration of human breast cancer MDA-MB-231 cells. | FAM3C-YY1 axis is essential for TGFβ-promoted proliferation and migration of human breast cancer MDA-MB-231 cells via the activation of HSF1.
Yang W, Feng B, Meng Y, Wang J, Geng B, Cui Q, Zhang H, Yang Y, Yang J., Free PMC Article | 07/18/2020 |
| ILEI signaling plays a role in the breast cancer tumor progression.ILEI binds to the cytokine receptor LIFR. | TGFβ promotes breast cancer stem cell self-renewal through an ILEI/LIFR signaling axis.
Woosley AN, Dalton AC, Hussey GS, Howley BV, Mohanty BK, Grelet S, Dincman T, Bloos S, Olsen SK, Howe PH., Free PMC Article | 12/7/2019 |
| In conclusion, these findings suggested that overexpression of FAM3C in human oral squamous cell carcinoma may predict a poor prognosis for oral squamous cell carcinoma patients. | Overexpression of FAM3C is associated with poor prognosis in oral squamous cell carcinoma.
Wu CC, Xiao Y, Li H, Mao L, Deng WW, Yu GT, Zhang WF, Sun ZJ. | 06/15/2019 |
| ILEI contributes to melanoma cell invasiveness in vivo without affecting primary tumor growth and is transcriptionally up-regulated by USF-1. | Interleukin-like EMT inducer (ILEI) promotes melanoma invasiveness and is transcriptionally up-regulated by upstream stimulatory factor-1 (USF-1).
Noguchi K, Dincman TA, Dalton AC, Howley BV, McCall BJ, Mohanty BK, Howe PH., Free PMC Article | 02/9/2019 |
| The ILEI appears to play a crucial role in mediating TGF-beta1-induced EMT through the Akt and ERK pathways, which may provide a therapeutic target for the treatment of fibrotic kidney diseases. | ILEI is an important intermediate participating in the formation of TGF-β1-induced renal tubular EMT.
Zhao X, Luo G, Fan Y, Ma X, Zhou J, Jiang H. | 04/7/2018 |
| Covalent dimerization of ILEI is associated with breast cancer metastasis. | Covalent dimerization of interleukin-like epithelial-to-mesenchymal transition (EMT) inducer (ILEI) facilitates EMT, invasion, and late aspects of metastasis.
Kral M, Klimek C, Kutay B, Timelthaler G, Lendl T, Neuditschko B, Gerner C, Sibilia M, Csiszar A. | 10/28/2017 |
| Data suggest that ILEI does not form interleukin-like four helix-bundle structures; ILEI exists as monomers and as covalent dimers; ILEI dimer exhibits a trans-linked domain swap converting an intramolecular disulfide to an intermolecular disulfide; dimeric ILEI appears to be involved in neoplastic invasiveness. | The interleukin-like epithelial-mesenchymal transition inducer ILEI exhibits a non-interleukin-like fold and is active as a domain-swapped dimer.
Jansson AM, Csiszar A, Maier J, Nyström AC, Ax E, Johansson P, Schiavone LH., Free PMC Article | 09/30/2017 |
| Results demonstrate that phenotype switching regulates ILEI expression, and that ILEI regulates partial phenotype switching in MITF-low melanoma cell lines. | Interleukin-like EMT inducer regulates partial phenotype switching in MITF-low melanoma cell lines.
Noguchi K, Dalton AC, Howley BV, McCall BJ, Yoshida A, Diehl JA, Howe PH., Free PMC Article | 09/23/2017 |
| Ectopic overexpression of UBE4A, but not UBE3C, in cells was downregulated in vitro migration and invasion in these cells. Cumulatively, our data reveals a novel post-translational regulatory mechanism of regulating ILEI1 expression, a protein required for metastatic progression in prostate cancer cells | The ubiquitin ligase UBE4A inhibits prostate cancer progression by targeting interleukin-like EMT inducer (ILEI).
Sun Y, Jia X, Gao Q, Liu X, Hou L. | 09/2/2017 |
| Study used immunohistochemical staining and biochemical fractionation to examine the regional distribution and subcellular localization of ILEI in mouse brains and in autopsy brains of patients with Alzheimer's disease; results suggest that a decline of ILEI expression may cause accumulation of Abeta in the brain and the eventual development of Alzheimer's disease. | Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer's disease.
Liu L, Watanabe N, Akatsu H, Nishimura M. | 07/15/2017 |
| FAM3C expression was dramatically increased in esophageal squamous cell carcinoma and might serve as a valuable prognostic indicator for esophageal squamous cell carcinoma patients after surgery | Prognostic significance of FAM3C in esophageal squamous cell carcinoma.
Zhu YH, Zhang B, Li M, Huang P, Sun J, Fu J, Guan XY., Free PMC Article | 03/19/2016 |
| Altered subcellular ILEI localization strongly correlates with high tumor cell-associated uPAR protein expression. | Interleukin-like epithelial-to-mesenchymal transition inducer activity is controlled by proteolytic processing and plasminogen-urokinase plasminogen activator receptor system-regulated secretion during breast cancer progression.
Csiszar A, Kutay B, Wirth S, Schmidt U, Macho-Maschler S, Schreiber M, Alacakaptan M, Vogel GF, Aumayr K, Huber LA, Beug H., Free PMC Article | 08/1/2015 |
| Our findings indicate that cytoplasmic ILEI expression is a potential marker of EMT and tumour progression in colorectal cancer. ILEI is an independent predictive factor associated with poor prognosis in colorectal cancer. | ILEI: a novel marker for epithelial-mesenchymal transition and poor prognosis in colorectal cancer.
Gao ZH, Lu C, Wang ZN, Song YX, Zhu JL, Gao P, Sun JX, Chen XW, Wang MX, Dong YL, Xu HM. | 07/25/2015 |
| ILEI could induce, as well as maintain, CD24(low)CD44(high) subpopulation in A549 cells treated with TGF-beta, which might explain its capability to induce metastatic progression. | ILEI drives epithelial to mesenchymal transition and metastatic progression in the lung cancer cell line A549.
Song Q, Sheng W, Zhang X, Jiao S, Li F. | 05/3/2014 |
| At the FAM3C gene locus where rs7776725 was located, we identified several other SNPs (rs4727922, rs1803389, rs718766 and rs7793554) that were also associated with BMD. | A follow-up association study of two genetic variants for bone mineral density variation in Caucasians.
Zhang LS, Hu HG, Liu YJ, Li J, Yu P, Zhang F, Yang TL, Tian Q, Zheng YP, Guo Y, Deng HW., Free PMC Article | 09/15/2012 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits.
Cho YS, Go MJ, Kim YJ, Heo JY, Oh JH, Ban HJ, Yoon D, Lee MH, Kim DJ, Park M, Cha SH, Kim JW, Han BG, Min H, Ahn Y, Park MS, Han HR, Jang HY, Cho EY, Lee JE, Cho NH, Shin C, Park T, Park JW, Lee JK, Cardon L, Clarke G, McCarthy MI, Lee JY, Lee JK, Oh B, Kim HL. | 05/6/2009 |