U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    MERTK MER proto-oncogene, tyrosine kinase [ Homo sapiens (human) ]

    Gene ID: 10461, updated on 11-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The Important Role of Phosphatidylserine, ADAM17, TNF-Alpha, and Soluble MER on Efferocytosis Activity in Central Obesity.

    The Important Role of Phosphatidylserine, ADAM17, TNF-Alpha, and Soluble MER on Efferocytosis Activity in Central Obesity.
    Purnama CA, Meiliana A, Barliana MI, Lestari K, Wijaya A., Free PMC Article

    04/3/2024
    Axl and MerTK regulate synovial inflammation and are modulated by IL-6 inhibition in rheumatoid arthritis.

    Axl and MerTK regulate synovial inflammation and are modulated by IL-6 inhibition in rheumatoid arthritis.
    Nerviani A, Boutet MA, Ghirardi GM, Goldmann K, Sciacca E, Rivellese F, Pontarini E, Prediletto E, Abatecola F, Caliste M, Pagani S, Mauro D, Bellan M, Cubuk C, Lau R, Church SE, Hudson BM, Humby F, Bombardieri M, Lewis MJ, Pitzalis C., Free PMC Article

    03/18/2024
    Semaphorin3B promotes an anti-inflammatory and pro-resolving phenotype in macrophages from rheumatoid arthritis patients in a MerTK-dependent manner.

    Semaphorin3B promotes an anti-inflammatory and pro-resolving phenotype in macrophages from rheumatoid arthritis patients in a MerTK-dependent manner.
    Martínez-Ramos S, Rafael-Vidal C, Malvar-Fernández B, Pérez N, Mouriño C, Pérez SG, Maceiras Pan FJ, Conde C, Pego-Reigosa JM, García S., Free PMC Article

    03/1/2024
    Big data analytics for MerTK genomics reveals its double-edged sword functions in human diseases.

    Big data analytics for MerTK genomics reveals its double-edged sword functions in human diseases.
    Liu S, Wu J, Yang D, Xu J, Shi H, Xue B, Ding Z., Free PMC Article

    02/28/2024
    Disruption of MerTK increases the efficacy of checkpoint inhibitor by enhancing ferroptosis and immune response in hepatocellular carcinoma.

    Disruption of MerTK increases the efficacy of checkpoint inhibitor by enhancing ferroptosis and immune response in hepatocellular carcinoma.
    Wang S, Zhu L, Li T, Lin X, Zheng Y, Xu D, Guo Y, Zhang Z, Fu Y, Wang H, Wang X, Zou T, Shen X, Zhang L, Lai N, Lu L, Qin L, Dong Q., Free PMC Article

    02/26/2024
    MerTK is a mediator of alpha-synuclein fibril uptake by human microglia.

    MerTK is a mediator of alpha-synuclein fibril uptake by human microglia.
    Dorion MF, Yaqubi M, Senkevich K, Kieran NW, MacDonald A, Chen CXQ, Luo W, Wallis A, Shlaifer I, Hall JA, Dudley RWR, Glass IA, Birth Defects Research Laboratory, Stratton JA, Fon EA, Bartels T, Antel JP, Gan-Or Z, Durcan TM, Healy LM., Free PMC Article

    02/7/2024
    HLA-DRB1*15:01 and the MERTK Gene Interact to Selectively Influence the Profile of MERTK-Expressing Monocytes in Both Health and MS.

    HLA-DRB1*15:01 and the MERTK Gene Interact to Selectively Influence the Profile of MERTK-Expressing Monocytes in Both Health and MS.
    Binder MD, Nwoke EC, Morwitch E, Dwyer C, Li V, Xavier A, Lea RA, Lechner-Scott J, Taylor BV, Ponsonby AL, Kilpatrick TJ, Ausimmune Investigator Group., Free PMC Article

    01/5/2024
    Regulation of brain endothelial cell physiology by the TAM receptor tyrosine kinase Mer.

    Regulation of brain endothelial cell physiology by the TAM receptor tyrosine kinase Mer.
    Happonen KE, Burrola PG, Lemke G., Free PMC Article

    09/8/2023
    Elevated expression of macrophage MERTK exhibits profibrotic effects and results in defective regulation of efferocytosis function in pulmonary fibrosis.

    Elevated expression of macrophage MERTK exhibits profibrotic effects and results in defective regulation of efferocytosis function in pulmonary fibrosis.
    She Y, Xu X, Yu Q, Yang X, He J, Tang XX., Free PMC Article

    08/25/2023
    MERTK missense variants in three patients with retinitis pigmentosa.

    MERTK missense variants in three patients with retinitis pigmentosa.
    Poli FE, Yusuf IH, Clouston P, Shanks M, Whitfield J, Charbel Issa P, MacLaren RE., Free PMC Article

    02/24/2023
    Mer-tyrosine kinase: a novel susceptibility gene for SLE related end-stage renal disease.

    Mer-tyrosine kinase: a novel susceptibility gene for SLE related end-stage renal disease.
    Yavuz S, Pucholt P, Sandling JK, Bianchi M, Leonard D, Bolin K, Imgenberg-Kreuz J, Eloranta ML, Kozyrev SV, Lanata CM, Jönsen A, Bengtsson AA, Sjöwall C, Svenungsson E, Gunnarsson I, Rantapää-Dahlqvist S, ImmunoArray Development Consortium, DISSECT Consortium, Nititham J, Criswell LA, Lindblad-Toh K, Rönnblom L., Free PMC Article

    11/12/2022
    Mer Tyrosine Kinase (MERTK) modulates liver fibrosis progression and hepatocellular carcinoma development.

    Mer Tyrosine Kinase (MERTK) modulates liver fibrosis progression and hepatocellular carcinoma development.
    Pipitone RM, Calvaruso V, Di Marco L, Di Salvo F, Gaggianesi M, Lupo G, Zito R, La Mantia C, Ramazzotti M, Petta S, Di Marco V, Craxì A, Grimaudo S., Free PMC Article

    09/3/2022
    Mertk: An emerging target in cancer biology and immuno-oncology.

    Mertk: An emerging target in cancer biology and immuno-oncology.
    Lahey KC, Gadiyar V, Hill A, Desind S, Wang Z, Davra V, Patel R, Zaman A, Calianese D, Birge RB., Free PMC Article

    06/18/2022
    High Glucose Impairs Expression and Activation of MerTK in ARPE-19 Cells.

    High Glucose Impairs Expression and Activation of MerTK in ARPE-19 Cells.
    Puddu A, Ravera S, Panfoli I, Bertola N, Maggi D., Free PMC Article

    03/12/2022
    Differential polarization and the expression of efferocytosis receptor MerTK on M1 and M2 macrophages isolated from coronary artery disease patients.

    Differential polarization and the expression of efferocytosis receptor MerTK on M1 and M2 macrophages isolated from coronary artery disease patients.
    Mohd Idrus FN, Ahmad NS, Hoe CH, Azlan M, Norfuad FA, Yusof Z, Wan Isa WYH, Mohamed Ali AA, Yvonne-Tee GB., Free PMC Article

    02/19/2022
    MerTK-mediated efferocytosis promotes immune tolerance and tumor progression in osteosarcoma through enhancing M2 polarization and PD-L1 expression.

    MerTK-mediated efferocytosis promotes immune tolerance and tumor progression in osteosarcoma through enhancing M2 polarization and PD-L1 expression.
    Lin J, Xu A, Jin J, Zhang M, Lou J, Qian C, Zhu J, Wang Y, Yang Z, Li X, Yu W, Liu B, Tao H., Free PMC Article

    02/5/2022
    MERTK retinopathy: biomarkers assessing vision loss.

    MERTK retinopathy: biomarkers assessing vision loss.
    Sakti DH, Cornish EE, Mustafic N, Zaheer A, Retsas S, Rajagopalan S, Chung CW, Ewans L, McCluskey P, Nash BM, Jamieson RV, Grigg JR.

    02/5/2022
    Mer tyrosine kinase as a possible link between resolution of inflammation and tissue fibrosis in IgG4-related disease.

    Mer tyrosine kinase as a possible link between resolution of inflammation and tissue fibrosis in IgG4-related disease.
    Rovati L, Kaneko N, Pedica F, Monno A, Maehara T, Perugino C, Lanzillotta M, Pecetta S, Stone JH, Doglioni C, Manfredi AA, Pillai S, Della-Torre E., Free PMC Article

    01/1/2022
    MERTK on mononuclear phagocytes regulates T cell antigen recognition at autoimmune and tumor sites.

    MERTK on mononuclear phagocytes regulates T cell antigen recognition at autoimmune and tumor sites.
    Lindsay RS, Whitesell JC, Dew KE, Rodriguez E, Sandor AM, Tracy D, Yannacone SF, Basta BN, Jacobelli J, Friedman RS., Free PMC Article

    12/4/2021
    MERTK-Mediated LC3-Associated Phagocytosis (LAP) of Apoptotic Substrates in Blood-Separated Tissues: Retina, Testis, Ovarian Follicles.

    MERTK-Mediated LC3-Associated Phagocytosis (LAP) of Apoptotic Substrates in Blood-Separated Tissues: Retina, Testis, Ovarian Follicles.
    Yefimova MG, Ravel C, Rolland AD, Bourmeyster N, Jégou B., Free PMC Article

    11/6/2021
    Role of the Gas6/TAM System as a Disease Marker and Potential Drug Target.

    Role of the Gas6/TAM System as a Disease Marker and Potential Drug Target.
    Sainaghi PP, Bellan M, Nerviani A., Free PMC Article

    10/30/2021
    Ligand-dependent kinase activity of MERTK drives efferocytosis in human iPSC-derived macrophages.

    Ligand-dependent kinase activity of MERTK drives efferocytosis in human iPSC-derived macrophages.
    Wanke F, Gutbier S, Rümmelin A, Steinberg M, Hughes LD, Koenen M, Komuczki J, Regan-Komito D, Wagage S, Hesselmann J, Thoma R, Brugger D, Christopeit T, Wang H, Point F, Hallet R, Ghosh S, Rothlin CV, Patsch C, Geering B., Free PMC Article

    09/25/2021
    Immunological role of TAM receptors in the cancer microenvironment.

    Immunological role of TAM receptors in the cancer microenvironment.
    Gadiyar V, Patel G, Davra V.

    09/4/2021
    Post-translational modifications of the ligands: Requirement for TAM receptor activation.

    Post-translational modifications of the ligands: Requirement for TAM receptor activation.
    Geng K.

    09/4/2021
    TAM receptors and their ligand-mediated activation: Role in atherosclerosis.

    TAM receptors and their ligand-mediated activation: Role in atherosclerosis.
    Cai B, Kasikara C., Free PMC Article

    09/4/2021
    firstprevious page of 7 nextlast