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    FST follistatin [ Homo sapiens (human) ]

    Gene ID: 10468, updated on 17-Jun-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Potential Utility of Urinary Follistatin as a Non-Invasive Indicator of Acute Tubular Damage in Patients with Acute Kidney Injury.

    Potential Utility of Urinary Follistatin as a Non-Invasive Indicator of Acute Tubular Damage in Patients with Acute Kidney Injury.
    Nagayama I, Takayanagi K, Nagata D, Hasegawa H, Maeshima A., Free PMC Article

    03/29/2024
    Elevated circulating follistatin associates with increased risk of mortality and cardiometabolic disorders.

    Elevated circulating follistatin associates with increased risk of mortality and cardiometabolic disorders.
    Pan J, Nilsson J, Engström G, De Marinis Y.

    03/13/2024
    Low follistatin level is a causal risk factor for spontaneous abortion: a two-sample mendelian randomization study.

    Low follistatin level is a causal risk factor for spontaneous abortion: a two-sample mendelian randomization study.
    Gong C, Yang W, Liu X, Li X, Wang Y, Tian C., Free PMC Article

    01/30/2024
    Follistatin and follistatin-like 3 in metabolic disorders.

    Follistatin and follistatin-like 3 in metabolic disorders.
    Bielka W, Przezak A, Pawlik A.

    11/14/2023
    Follistatin-controlled activin-HNF4alpha-coagulation factor axis in liver progenitor cells determines outcome of acute liver failure.

    Follistatin-controlled activin-HNF4α-coagulation factor axis in liver progenitor cells determines outcome of acute liver failure.
    Lin T, Wang S, Munker S, Jung K, Macías-Rodríguez RU, Ruiz-Margáin A, Schierwagen R, Liu H, Shao C, Fan C, Feng R, Yuan X, Wang S, Wandrer F, Meyer C, Wimmer R, Liebe R, Kroll J, Zhang L, Schiergens T, Ten Dijke P, Teufel A, Marx A, Mertens PR, Wang H, Ebert MPA, Bantel H, N De Toni E, Trebicka J, Dooley S, Shin D, Ding H, Weng HL.

    03/5/2022
    Effects of Roux-en-Y gastric bypass on circulating follistatin, activin A, and peripheral ActRIIB signaling in humans with obesity and type 2 diabetes.

    Effects of Roux-en-Y gastric bypass on circulating follistatin, activin A, and peripheral ActRIIB signaling in humans with obesity and type 2 diabetes.
    Pham TCP, Bojsen-Møller KN, Madsbad S, Wojtaszewski JFP, Richter EA, Sylow L.

    01/8/2022
    Identification of frailty and sarcopenia in hospitalised older people.

    Identification of frailty and sarcopenia in hospitalised older people.
    Echeverria I, Besga A, Sanz B, Amasene M, Hervás G, Barroso J, Rodriguez-Larrad A, Irazusta J.

    12/4/2021
    Clinical relevance of circulating activin A and follistatin in small cell lung cancer.

    Clinical relevance of circulating activin A and follistatin in small cell lung cancer.
    Barany N, Rozsas A, Megyesfalvi Z, Grusch M, Hegedus B, Lang C, Boettiger K, Schwendenwein A, Tisza A, Renyi-Vamos F, Schelch K, Hoetzenecker K, Hoda MA, Paku S, Laszlo V, Dome B.

    10/30/2021
    Serum Follistatin Is Increased in Thyroid Cancer and Is Associated With Adverse Tumor Characteristics in Humans.

    Serum Follistatin Is Increased in Thyroid Cancer and Is Associated With Adverse Tumor Characteristics in Humans.
    Panagiotou G, Ghaly W, Upadhyay J, Pazaitou-Panayiotou K, Mantzoros CS.

    10/2/2021
    Circulating resistin and follistatin levels in obese and non-obese women with polycystic ovary syndrome: A systematic review and meta-analysis.

    Circulating resistin and follistatin levels in obese and non-obese women with polycystic ovary syndrome: A systematic review and meta-analysis.
    Raeisi T, Rezaie H, Darand M, Taheri A, Garousi N, Razi B, Roever L, Mohseni R, Hussien Mohammed S, Alizadeh S., Free PMC Article

    08/28/2021
    The effects of concurrent training order on body composition and serum concentrations of follistatin, myostatin and GDF11 in sarcopenic elderly men.

    The effects of concurrent training order on body composition and serum concentrations of follistatin, myostatin and GDF11 in sarcopenic elderly men.
    Bagheri R, Moghadam BH, Church DD, Tinsley GM, Eskandari M, Moghadam BH, Motevalli MS, Baker JS, Robergs RA, Wong A.

    05/8/2021
    Regulatory aspects of myogenic factors GDF-8 and Follistatin on the intake of combined oral contraceptives.

    Regulatory aspects of myogenic factors GDF-8 and Follistatin on the intake of combined oral contraceptives.
    Wallner C, Rausch A, Drysch M, Dadras M, Wagner JM, Becerikli M, Lehnhardt M, Behr B.

    02/13/2021
    Follistatin impacts Tumor Angiogenesis and Outcome in Thymic Epithelial Tumors.

    Follistatin impacts Tumor Angiogenesis and Outcome in Thymic Epithelial Tumors.
    Janik S, Bekos C, Hacker P, Raunegger T, Schiefer AI, Müllauer L, Veraar C, Dome B, Klepetko W, Ankersmit HJ, Moser B., Free PMC Article

    11/28/2020
    Study presents evidence that Fst is a potent regulator of insulin action in muscle. Circulating Fst more than doubled post-Roux-en-Y gastric bypass surgery in obese patients, a treatment that markedly improved insulin sensitivity, suggesting a role for Fst in regulating glycaemic control.

    Mechanisms involved in follistatin-induced hypertrophy and increased insulin action in skeletal muscle.
    Han X, Møller LLV, De Groote E, Bojsen-Møller KN, Davey J, Henríquez-Olguin C, Li Z, Knudsen JR, Jensen TE, Madsbad S, Gregorevic P, Richter EA, Sylow L., Free PMC Article

    08/1/2020
    performances of serum activins and follistatin in the diagnosis of ectopic pregnancy: A prospective case-control study

    The performances of serum activins and follistatin in the diagnosis of ectopic pregnancy: A prospective case-control study.
    Refaat B, Bahathiq AO.

    06/6/2020
    Activin A even inhibits production and release of follistatin in RASF and therefore prevents itself from being blocked by its inhibitory binding protein follistatin in the local inflammatory joint environment.

    The activin-follistatin anti-inflammatory cycle is deregulated in synovial fibroblasts.
    Diller M, Frommer K, Dankbar B, Tarner I, Hülser ML, Tsiklauri L, Hasseli R, Sauerbier M, Pap T, Rehart S, Müller-Ladner U, Neumann E., Free PMC Article

    05/30/2020
    The aim of this study was to investigate the effect of FST gene on the inhibition of fibrosis in fibroblastic cells from scar tissue around repaired zone II flexor tendons.

    Follistatin Mitigates Myofibroblast Differentiation and Collagen Synthesis of Fibroblasts from Scar Tissue around Injured Flexor Tendons.
    Kang YM, Lee SK, Chun YM, Choi YR, Moon SH, Lee HM, Kang HJ., Free PMC Article

    03/21/2020
    Activin A (follicle-stimulating hormone-releasing protein inhibin beta A subunit inhibin beta A) signaling is restrained in normal mammary epithelia by concomitant inhibin alpha-subunit expression, and relatively higher levels of follistatin (FST) expression, however, these expression patterns are reversed in breast cancer [Review].

    The Activin Social Network: Activin, Inhibin, and Follistatin in Breast Development and Cancer.
    Seachrist DD, Keri RA., Free PMC Article

    12/21/2019
    Fst is a pathological hepatokine that might be targeted for diabetes therapy during hepatic insulin resistance.

    Inactivating hepatic follistatin alleviates hyperglycemia.
    Tao R, Wang C, Stöhr O, Qiu W, Hu Y, Miao J, Dong XC, Leng S, Stefater M, Stylopoulos N, Lin L, Copps KD, White MF., Free PMC Article

    05/11/2019
    Circulating plasma follistatin and myostatin are negatively associated with muscle function in older women.

    Relationship of muscle function to circulating myostatin, follistatin and GDF11 in older women and men.
    Fife E, Kostka J, Kroc Ł, Guligowska A, Pigłowska M, Sołtysik B, Kaufman-Szymczyk A, Fabianowska-Majewska K, Kostka T., Free PMC Article

    04/27/2019
    these studies suggest that follistatin expression in invasive breast cancer is unrelated to the disease severity and the risk of recurrence, but is more intense in estrogen receptor -negative tumors

    Follistatin Expression in Human Invasive Breast Tumors: Pathologic and Clinical Associations.
    Couto HL, Dela Cruz C, Buzelin MA, Toppa NH, Wainstein AJ, Reis FM.

    08/25/2018
    Surface plasmon resonance analysis showed no significant association between FS288 and AMHC , suggesting that FS288 indirectly regulates AMH signaling. Activin A, a direct target of FS288, did not itself induce reporter activity in P19 cells, but did prevent the FS288-induced increase in AMH signaling. Hence, local concentrations of FS288 and Activin A may influence the response of some cell types to AMH.

    Anti-Müllerian hormone signaling is influenced by Follistatin 288, but not 14 other transforming growth factor beta superfamily regulators.
    Kawagishi Y, Pankhurst MW, Nakatani Y, McLennan IS.

    04/14/2018
    results suggest a role for FST as a suppressor of invasion and metastasis in breast cancer

    Increased Expression of Follistatin in Breast Cancer Reduces Invasiveness and Clinically Correlates with Better Survival.
    Zabkiewicz C, Resaul J, Hargest R, Jiang WG, Ye L., Free PMC Article

    04/7/2018
    These data indicate that FST is a bona fide metastasis suppressor in this mouse model and support future efforts to develop an FST mimetic to suppress metastatic progression.

    Follistatin is a metastasis suppressor in a mouse model of HER2-positive breast cancer.
    Seachrist DD, Sizemore ST, Johnson E, Abdul-Karim FW, Weber Bonk KL, Keri RA., Free PMC Article

    03/31/2018
    These findings indicate that muscle-specific Fst overexpression in pigs enhances skeletal muscle growth, at least partly due to myofiber hypertrophy and providing a promising approach to increase muscle mass in pigs and other livestock.

    The transgenic expression of human follistatin-344 increases skeletal muscle mass in pigs.
    Chang F, Fang R, Wang M, Zhao X, Chang W, Zhang Z, Li N, Meng Q.

    01/6/2018
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