| Dysregulated CREB3 cleavage at the nuclear membrane induces karyoptosis-mediated cell death. | Dysregulated CREB3 cleavage at the nuclear membrane induces karyoptosis-mediated cell death.
Lee GE, Bang G, Byun J, Lee CJ, Chen W, Jeung D, An HJ, Kang HC, Lee JY, Lee HS, Hong YS, Kim DJ, Keniry M, Kim JY, Choi JS, Fanto M, Cho SJ, Kim KD, Cho YY., Free PMC Article | 04/12/2024 |
| CREB3 Plays an Important Role in HPSE-Facilitated HSV-1 Release in Human Corneal Epithelial Cells. | CREB3 Plays an Important Role in HPSE-Facilitated HSV-1 Release in Human Corneal Epithelial Cells.
Yadavalli T, Sharma P, Wu D, Kapoor D, Shukla D., Free PMC Article | 07/2/2022 |
| Role of small leucine zipper protein in hepatic gluconeogenesis and metabolic disorder. | Role of small leucine zipper protein in hepatic gluconeogenesis and metabolic disorder.
Kang M, Han SK, Kim S, Park S, Jo Y, Kang H, Ko J., Free PMC Article | 02/19/2022 |
| Comparative Analysis of CREB3 and CREB3L2 Protein Expression in HEK293 Cells. | Comparative Analysis of CREB3 and CREB3L2 Protein Expression in HEK293 Cells.
Oh-Hashi K, Yamamoto A, Murase R, Hirata Y., Free PMC Article | 04/24/2021 |
| Knockdown of CREB3 activates endoplasmic reticulum stress and induces apoptosis in glioblastoma. | Knockdown of CREB3 activates endoplasmic reticulum stress and induces apoptosis in glioblastoma.
Hu Y, Chu L, Liu J, Yu L, Song SB, Yang H, Han F., Free PMC Article | 10/24/2020 |
| The stability of CREB3/Luman is regulated by protein kinase CK2 phosphorylation. | The stability of CREB3/Luman is regulated by protein kinase CK2 phosphorylation.
Schmitt BM, Ampofo E, Stumpf H, Montenarh M, Götz C. | 09/12/2020 |
| Endogenous full-length CREB3 was identified as a novel substrate for ERAD in HEK293 cells. | Regulation of the ER-bound transcription factor Luman/CREB3 in HEK293 cells.
Oh-Hashi K, Takahashi K, Hirata Y. | 06/20/2020 |
| Results show that CREB3 is a direct target of miR-203a and is considered an oncogene in osteosarcoma tumors and cell lines. | Circular RNA circTADA2A promotes osteosarcoma progression and metastasis by sponging miR-203a-3p and regulating CREB3 expression.
Wu Y, Xie Z, Chen J, Chen J, Ni W, Ma Y, Huang K, Wang G, Wang J, Ma J, Shen S, Fan S., Free PMC Article | 08/24/2019 |
| CREB3 was identified as a transcriptional regulator of upregulated ER-Golgi trafficking genes ARF4, COPB1, and USO1, and silencing of these genes attenuated the metastatic phenotype in vitro and lung colonization in vivo. Modulation of ER-Golgi trafficking plays an important role in metastatic progression. | A CREB3-regulated ER-Golgi trafficking signature promotes metastatic progression in breast cancer.
Howley BV, Link LA, Grelet S, El-Sabban M, Howe PH., Free PMC Article | 03/16/2019 |
| Luman, a ubiquitous, non-canonical unfolded protein response (UPR), is identified as a novel regulator of endoplasmic reticulum stress-induced PRNP expression. | Luman contributes to brefeldin A-induced prion protein gene expression by interacting with the ERSE26 element.
Déry MA, LeBlanc AC., Free PMC Article | 11/10/2018 |
| In summary, the authors show here that hepatitis C virus infection is associated with an upregulation of ARF4, which promotes hepatitis C virus replication. Upon hepatitis C virus infection, CREB3 was redistributed to nucleus and activated ARF4 transcription. | Interplay between hepatitis C virus and ARF4.
Zhang N, Ke Y, Zhang L., Free PMC Article | 07/28/2018 |
| sLZIP is a novel co-repressor of ERalpha, and plays a negative role in ERalpha-mediated cell proliferation in breast cancer | Small leucine zipper protein functions as a negative regulator of estrogen receptor α in breast cancer.
Jeong J, Park S, An HT, Kang M, Ko J., Free PMC Article | 10/7/2017 |
| These findings indicate that LZIP is a novel modulator of APOA4 expression and hepatic lipid metabolism. | Human leucine zipper protein promotes hepatic steatosis via induction of apolipoprotein A-IV.
Kang M, Kim J, An HT, Ko J. | 09/16/2017 |
| The authors found that the CREB3/Herp pathway limited the increase in cytosolic Ca2+ concentration and apoptosis early in poliovirus infection and this may reduce the extent of poliovirus-induced damage to the central nervous system during poliomyelitis. | The CREB3-Herp signalling module limits the cytosolic calcium concentration increase and apoptosis induced by poliovirus.
Mirabelli C, Pelletier I, Téoulé F, Vidalain PO, Brisac C, Tangy F, Delpeyroux F, Blondel B. | 05/6/2017 |
| The essential parts of the Golgi stress response from the perspective of the organelle autoregulation. The pathways of the mammalian Golgi stress response have been identified, specifically the CREB3 pathway. | TFE3, HSP47, and CREB3 Pathways of the Mammalian Golgi Stress Response.
Taniguchi M, Yoshida H. | 04/15/2017 |
| These results indicate that sLZIP plays a role in expression of c-Jun, and migration and invasion of cervical cancer cells via regulation of MMP-9 transcription. | The role of sLZIP in transcriptional regulation of c-Jun and involvement in migration and invasion of cervical cancer cells.
Park E, Kang H, Kim J, Ko J. | 07/30/2016 |
| INHA gene expression is upregulated by cAMP via CRE in human trophoblasts, and TFAP2 regulates this expression by interacting with CRE. | Inhibin alpha gene expression in human trophoblasts is regulated by interactions between TFAP2 and cAMP signaling pathways.
Depoix CL, Debiève F, Hubinont C. | 07/25/2015 |
| Findings indicate that sLZIP negatively regulates AR transactivation in androgen-dependent PCa cells and functions as a positive regulator in tumor progression of androgen-independent PCa. sLZIP contributes to the malignant phenotype of PCa. | The role of sLZIP in cyclin D3-mediated negative regulation of androgen receptor transactivation and its involvement in prostate cancer.
Kim Y, Kim J, Jang SW, Ko J. | 05/2/2015 |
| human sLZIP plays a critical role in development of atherosclerosis and can be used as a therapeutic target molecule for treatment of atherosclerosis | Human sLZIP promotes atherosclerosis via MMP-9 transcription and vascular smooth muscle cell migration.
Kim J, Ko J. | 01/31/2015 |
| A CREB3-ARF4 signalling cascade may be part of a Golgi stress response set in motion by stimuli compromising Golgi capacity. | A CREB3-ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens.
Reiling JH, Olive AJ, Sanyal S, Carette JE, Brummelkamp TR, Ploegh HL, Starnbach MN, Sabatini DM., Free PMC Article | 02/8/2014 |
| propose that JAB1 is a novel binding partner of Luman, which negatively regulates the activity of Luman by promoting its degradation | JAB1/CSN5 inhibits the activity of Luman/CREB3 by promoting its degradation.
DenBoer LM, Iyer A, McCluggage AR, Li Y, Martyn AC, Lu R., Free PMC Article | 09/21/2013 |
| GSK3beta was downregulate in all samples and CREB3 did not show a significant decrease or increase in its mRNA expression, but the results were significant in mucoepidermoid carcinoma and salivary duct carcinoma. | GSK3β and CREB3 gene expression profiling in benign and malignant salivary gland tumors.
Mohammadi Ghahhari N, Mohammadi Ghahhari H, Kadivar M., Free PMC Article | 06/29/2013 |
| sLZIP plays a critical role in MMP-9 expression and is probably involved in invasion and metastasis of cervical cancer | Human leucine zipper protein sLZIP induces migration and invasion of cervical cancer cells via expression of matrix metalloproteinase-9.
Kang H, Jang SW, Ko J., Free PMC Article | 02/25/2012 |
| sLZIP-regulated ARF4 expression in response to phorbol 12-myristate 13-acetate is involved in breast cancer cell migration. | Regulation of ADP-ribosylation factor 4 expression by small leucine zipper protein and involvement in breast cancer cell migration.
Jang SY, Jang SW, Ko J. | 01/14/2012 |
| These findings suggest that HDAC3 selectively represses CREB3-mediated transcriptional activation and chemotactic signalling in human metastatic breast cancer cells. | HDAC3 selectively represses CREB3-mediated transcription and migration of metastatic breast cancer cells.
Kim HC, Choi KC, Choi HK, Kang HB, Kim MJ, Lee YH, Lee OH, Lee J, Kim YJ, Jun W, Jeong JW, Yoon HG., Free PMC Article | 10/23/2010 |