| Intratumoral Restoration of miR-137 Plus Cholesterol Favors Homeostasis of the miR-137/Coactivator p160/AR Axis and Negatively Modulates Tumor Progression in Advanced Prostate Cancer. | Intratumoral Restoration of miR-137 Plus Cholesterol Favors Homeostasis of the miR-137/Coactivator p160/AR Axis and Negatively Modulates Tumor Progression in Advanced Prostate Cancer.
Pimenta R, Mioshi CM, Gonçalves GL, Candido P, Camargo JA, Guimarães VR, Chiovatto C, Ghazarian V, Romão P, da Silva KS, Dos Santos GA, Silva IA, Srougi M, Nahas WC, Leite KR, Viana NI, Reis ST., Free PMC Article | 06/15/2023 |
| Characterization of the impact of the MYBBP1A gene and rs3809849 on asparaginase sensitivity and cellular functions. | Characterization of the impact of the MYBBP1A gene and rs3809849 on asparaginase sensitivity and cellular functions.
Abaji R, Roux V, Yssaad IR, Kalegari P, Gagné V, Gioia R, Ferbeyre G, Beauséjour C, Krajinovic M. | 05/28/2022 |
| This study shows the capability of MYBBP1A to regulate glucose metabolism through c-MYB and PGC1alpha in human tumors. | c-MYB- and PGC1a-dependent metabolic switch induced by MYBBP1A loss in renal cancer.
Felipe-Abrio B, Verdugo-Sivianes EM, Carnero A., Free PMC Article | 05/16/2020 |
| The results indicated that both the heterozygous genotype GC and homozygous genotype CC in rs3809849 in MYBBP1A had significant effects on the risk of pulmonary tuberculosis, and heterozygous genotype CT in rs9061 in SP110 also had similar effects. | The effects of SP110's associated genes on fresh cavitary pulmonary tuberculosis in Han Chinese population.
Jiang SY, Li LL, Yue J, Chen WZ, Yang C, Wan CL, He L, Cai L, Deng SL. | 02/4/2017 |
| We propose that the nucleolus functions as a stress sensor to modulate p53 protein levels and its acetylation status, determining cell fate between cell cycle arrest and apoptosis by regulating MYBBP1A translocation. | Gradual reduction in rRNA transcription triggers p53 acetylation and apoptosis via MYBBP1A.
Kumazawa T, Nishimura K, Katagiri N, Hashimoto S, Hayashi Y, Kimura K., Free PMC Article | 03/26/2016 |
| MYBBP1A(low)AKT(Ser473)(high) staining pattern serves not only as a marker for the pre-senescent stage but also as an indicator of OPSCC patients at high risk for treatment failure. | Regulation and function of Myb-binding protein 1A (MYBBP1A) in cellular senescence and pathogenesis of head and neck cancer.
George B, Horn D, Bayo P, Zaoui K, Flechtenmacher C, Grabe N, Plinkert P, Krizhanovsky V, Hess J. | 04/18/2015 |
| TPPII, MYBBP1A and CDK2 form a protein-protein interaction network. | TPPII, MYBBP1A and CDK2 form a protein-protein interaction network.
Nahálková J, Tomkinson B. | 02/14/2015 |
| MYBBP1A functions to enhance p53 tetramerization that is necessary for p53 activation. | The nucleolar protein Myb-binding protein 1A (MYBBP1A) enhances p53 tetramerization and acetylation in response to nucleolar disruption.
Ono W, Hayashi Y, Yokoyama W, Kuroda T, Kishimoto H, Ito I, Kimura K, Akaogi K, Waku T, Yanagisawa J., Free PMC Article | 04/26/2014 |
| Mybbp1a is a novel negative regulator of Sirt7. | Inhibition of H3K18 deacetylation of Sirt7 by Myb-binding protein 1a (Mybbp1a).
Karim MF, Yoshizawa T, Sato Y, Sawa T, Tomizawa K, Akaike T, Yamagata K. | 01/18/2014 |
| Regulators, including BCL11A, MYB, and KLF1, hold great promise to develop targeted and more effective approaches for HbF induction. | The switch from fetal to adult hemoglobin.
Sankaran VG, Orkin SH., Free PMC Article | 07/27/2013 |
| MYBBP1A-p53 binding property can account for efficient p53-activation by MYBBP1A under nucleolar stress. Our results support the idea that MYBBP1A plays catalytic roles in p53 acetylation and activation | Nucleolar protein, Myb-binding protein 1A, specifically binds to nonacetylated p53 and efficiently promotes transcriptional activation.
Ono W, Akaogi K, Waku T, Kuroda T, Yokoyama W, Hayashi Y, Kimura K, Kishimoto H, Yanagisawa J. | 07/27/2013 |
| Suggest that MYBBP1A is required for p53 activation during anoikis; therefore, it is involved in suppressing colony formation and the tumorigenesis of breast cancer cells. | MYBBP1A suppresses breast cancer tumorigenesis by enhancing the p53 dependent anoikis.
Akaogi K, Ono W, Hayashi Y, Kishimoto H, Yanagisawa J., Free PMC Article | 06/15/2013 |
| Data show that down-regulation of MYBBP1A decreases the growth rate of wild type mouse embryonic stem cells, embryo fibroblasts (MEFs) and of human HeLa cells, where it also promotes apoptosis. | Myb-binding protein 1A (MYBBP1A) is essential for early embryonic development, controls cell cycle and mitosis, and acts as a tumor suppressor.
Mori S, Bernardi R, Laurent A, Resnati M, Crippa A, Gabrieli A, Keough R, Gonda TJ, Blasi F., Free PMC Article | 04/6/2013 |
| Study suggests that a combination of SP110 and MYBBP1A gene polymorphisms may serve as a novel marker for identifying the risk of developing TB in the Chinese Han population. | Identification of genetic associations of SP110/MYBBP1A/RELA with pulmonary tuberculosis in the Chinese Han population.
Cai L, Deng SL, Liang L, Pan H, Zhou J, Wang MY, Yue J, Wan CL, He G, He L. | 03/30/2013 |
| Results from our present work reveal a previously unrecognized co-repressor role of Mybbp1a in rRNA expression. | Epigeneitc silencing of ribosomal RNA genes by Mybbp1a.
Tan BC, Yang CC, Hsieh CL, Chou YH, Zhong CZ, Yung BY, Liu H., Free PMC Article | 01/5/2013 |
| Mybbp1a may play a dual role in the rRNA metabolism, potentially linking and coordinating ribosomal DNA transcription and pre-rRNA processing to allow for the efficient synthesis of ribosomes. | Myb-binding protein 1a (Mybbp1a) regulates levels and processing of pre-ribosomal RNA.
Hochstatter J, Hölzel M, Rohrmoser M, Schermelleh L, Leonhardt H, Keough R, Gonda TJ, Imhof A, Eick D, Längst G, Németh A., Free PMC Article | 09/29/2012 |
| We provide experimental evidence that MYBBP1A is an important molecular switch in the regulation of tumor cell proliferation versus migration in head and neck squamous cell carcinoma cells. | Opposing function of MYBBP1A in proliferation and migration of head and neck squamous cell carcinoma cells.
Acuña Sanhueza GA, Faller L, George B, Koffler J, Misetic V, Flechtenmacher C, Dyckhoff G, Plinkert PP, Angel P, Simon C, Hess J., Free PMC Article | 07/21/2012 |
| When rRNA transcription was suppressed by nucleolar stress, MYBBP1A translocated to the nucleoplasm and facilitated p53-p300 interaction to enhance p53 acetylation. | RNA content in the nucleolus alters p53 acetylation via MYBBP1A.
Kuroda T, Murayama A, Katagiri N, Ohta YM, Fujita E, Masumoto H, Ema M, Takahashi S, Kimura K, Yanagisawa J., Free PMC Article | 05/21/2011 |
| identified MYBBP1A as a novel Aurora B substrate and serine 1303 as the major phosphorylation site | Identification of Myb-binding protein 1A (MYBBP1A) as a novel substrate for aurora B kinase.
Perrera C, Colombo R, Valsasina B, Carpinelli P, Troiani S, Modugno M, Gianellini L, Cappella P, Isacchi A, Moll J, Rusconi L., Free PMC Article | 05/10/2010 |
| Myb-binding protein 1a was identified in anti-SMN pulldowns as interacting with SMN proteins. | The SMN interactome includes Myb-binding protein 1a.
Fuller HR, Man NT, Lam le T, Thanh le T, Keough RA, Asperger A, Gonda TJ, Morris GE. | 04/12/2010 |
| SRC-1 is a strong independent predictor of reduced disease free survival, whereas the interactions of the p160 proteins with estrogen receptor alpha can predict the response of patients to endocrine treatment. | Coassociation of estrogen receptor and p160 proteins predicts resistance to endocrine treatment; SRC-1 is an independent predictor of breast cancer recurrence.
Redmond AM, Bane FT, Stafford AT, McIlroy M, Dillon MF, Crotty TB, Hill AD, Young LS. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
Lu Y, Dollé ME, Imholz S, van 't Slot R, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM. | 09/24/2008 |
| Expression of Ets-2, SRC-1 and c-Myc individually are all associated with reduced disease-free survival in breast cancer | Ets-2 and p160 proteins collaborate to regulate c-Myc in endocrine resistant breast cancer.
Al-azawi D, Ilroy MM, Kelly G, Redmond AM, Bane FT, Cocchiglia S, Hill AD, Young LS. | 01/21/2010 |
| These results indicate that MYBBP1a is a novel NF-kappaB co-repressor of transcription that competes with p300 and may function to regulate cell type specific genes. | MYBBP1a is a novel repressor of NF-kappaB.
Owen HR, Elser M, Cheung E, Gersbach M, Kraus WL, Hottiger MO. | 01/21/2010 |