| Common single-base insertions in the VNTR of the carboxyl ester lipase (CEL) gene are benign and also likely to arise somatically in the exocrine pancreas. | Common single-base insertions in the VNTR of the carboxyl ester lipase (CEL) gene are benign and also likely to arise somatically in the exocrine pancreas.
Brekke RS, Gravdal A, El Jellas K, Curry GE, Lin J, Wilhelm SJ, Steine SJ, Mas E, Johansson S, Lowe ME, Johansson BB, Xiao X, Fjeld K, Molven A., Free PMC Article | 05/24/2024 |
| Effects of bile salt-stimulated lipase on blood cells and associations with disease activity in human inflammatory joint disorders. | Effects of bile salt-stimulated lipase on blood cells and associations with disease activity in human inflammatory joint disorders.
Lindquist S, Wang Y, Andersson EL, Tsuji Grebe S, Alenius GM, Rantapää-Dahlqvist S, Lundberg L, Hernell O., Free PMC Article | 08/14/2023 |
| Triacylglycerols containing branched palmitic acid ester of hydroxystearic acid (PAHSA) are present in the breast milk and hydrolyzed by carboxyl ester lipase. | Triacylglycerols containing branched palmitic acid ester of hydroxystearic acid (PAHSA) are present in the breast milk and hydrolyzed by carboxyl ester lipase.
Brejchova K, Paluchova V, Brezinova M, Cajka T, Balas L, Durand T, Krizova M, Stranak Z, Kuda O. | 06/11/2022 |
| Two New Mutations in the CEL Gene Causing Diabetes and Hereditary Pancreatitis: How to Correctly Identify MODY8 Cases. | Two New Mutations in the CEL Gene Causing Diabetes and Hereditary Pancreatitis: How to Correctly Identify MODY8 Cases.
El Jellas K, Dušátková P, Haldorsen IS, Molnes J, Tjora E, Johansson BB, Fjeld K, Johansson S, Průhová Š, Groop L, Löhr JM, Njølstad PR, Molven A., Free PMC Article | 04/23/2022 |
| Single nucleotide polymorphisms in CEL-HYB1 increase risk for chronic pancreatitis through proteotoxic misfolding. | Single nucleotide polymorphisms in CEL-HYB1 increase risk for chronic pancreatitis through proteotoxic misfolding.
Cassidy BM, Zino S, Fjeld K, Molven A, Lowe ME, Xiao X., Free PMC Article | 11/13/2021 |
| Generation of beta Cells from iPSC of a MODY8 Patient with a Novel Mutation in the Carboxyl Ester Lipase (CEL) Gene. | Generation of β Cells from iPSC of a MODY8 Patient with a Novel Mutation in the Carboxyl Ester Lipase (CEL) Gene.
Pellegrini S, Pipitone GB, Cospito A, Manenti F, Poggi G, Lombardo MT, Nano R, Martino G, Ferrari M, Carrera P, Sordi V, Piemonti L. | 10/2/2021 |
| Protein misfolding in combination with other risk factors in CEL-HYB1-mediated chronic pancreatitis. | Protein misfolding in combination with other risk factors in CEL-HYB1-mediated chronic pancreatitis.
Tjora E, Gravdal A, Engjom T, Cnop M, Johansson BB, Dimcevski GG, Molven A, Fjeld K. | 09/18/2021 |
| Pathogenic Carboxyl Ester Lipase (CEL) Variants Interact with the Normal CEL Protein in Pancreatic Cells. | Pathogenic Carboxyl Ester Lipase (CEL) Variants Interact with the Normal CEL Protein in Pancreatic Cells.
Dalva M, Lavik IK, El Jellas K, Gravdal A, Lugea A, Pandol SJ, Njølstad PR, Waldron RT, Fjeld K, Johansson BB, Molven A., Free PMC Article | 04/3/2021 |
| Characterization of CEL-DUP2: Complete duplication of the carboxyl ester lipase gene is unlikely to influence risk of chronic pancreatitis. | Characterization of CEL-DUP2: Complete duplication of the carboxyl ester lipase gene is unlikely to influence risk of chronic pancreatitis.
Fjeld K, Masson E, Lin JH, Michl P, Stokowy T, Gravdal A, El Jellas K, Steine SJ, Hoem D, Johansson BB, Dalva M, Ruffert C, Zou WB, Li ZS, Njølstad PR, Chen JM, Liao Z, Johansson S, Rosendahl J, Férec C, Molven A. | 02/27/2021 |
| No statistical significant difference in the copy number of exon 11 repeats, or combinations of, in the Bile-salt stimulate lipase (BSSL) gene is observed when comparing homosexual male cohort composed of Hepatitis C (HCV) multiple exposed uninfected and multiple exposed HCV infected individuals. The exon 11 repeat copy number in the BSSL gene does not affect HCV susceptibility. | Bile-salt stimulated lipase polymorphisms do not associate with HCV susceptibility.
Steba GS, Koekkoek SM, Prins M, Brinkman K, Kwa D, van der Meer JTM, van der Valk M, Molenkamp R, Pollakis G, Schinkel J, Paxton WA, MOSAIC (MSM observational Study of Acute infection with Hepatitis C) study group. | 07/4/2020 |
| Studied association between carboxyl ester lipase (CEL) expression in breast cancer (BC) tissues and the survival of BC patients by analyzing The Cancer Genome Atlas Breast Carcinoma level 3 database. Found high CEL expression was associated with the poor overall survival of breast cancer. | A new prognostic factor of breast cancer: High carboxyl ester lipase expression related to poor survival.
Cui Y, Jiao Y, Wang K, He M, Yang Z. | 05/2/2020 |
| This study found no statistically significant association between CEL-HYB1 and chronic pancreatitis in a cohort of Polish pediatric chronic pancreatitis patients | The hybrid allele 1 of carboxyl-ester lipase (CEL-HYB1) in Polish pediatric patients with chronic pancreatitis.
Oracz G, Kujko AA, Fjeld K, Wertheim-Tysarowska K, Adamus-Białek W, Steine SJ, Koziel D, Gluszek S, Molven A, Rygiel AM. | 01/4/2020 |
| BAL has inverted stereoselectivity for the surrogates of nerve agent compared to human cholinesterases | X-ray structures of human bile-salt activated lipase conjugated to nerve agents surrogates.
Touvrey C, Courageux C, Guillon V, Terreux R, Nachon F, Brazzolotto X. | 05/18/2019 |
| mucinous domain of pancreatic carboxyl-ester lipase (CEL) contains core 1/core 2 O-glycans that can be modified by ABO blood group determinants | The mucinous domain of pancreatic carboxyl-ester lipase (CEL) contains core 1/core 2 O-glycans that can be modified by ABO blood group determinants.
El Jellas K, Johansson BB, Fjeld K, Antonopoulos A, Immervoll H, Choi MH, Hoem D, Lowe ME, Lombardo D, Njølstad PR, Dell A, Mas E, Haslam SM, Molven A., Free PMC Article | 04/13/2019 |
| Data suggest that anti-PRAAHG antibodies were uniquely reactive with a short isoform of BSDL specifically expressed in pre-neoplastic lesions of the pancreas. The detection of truncated BSDL reactive to antibodies against the PRAAHG C-terminal sequence in pancreatic juice or in pancreatic biopsies may be a new tool in the early diagnosis of PDAC. | Expression of truncated bile salt-dependent lipase variant in pancreatic pre-neoplastic lesions.
Martinez E, Crenon I, Silvy F, Del Grande J, Mougel A, Barea D, Fina F, Bernard JP, Ouaissi M, Lombardo D, Mas E., Free PMC Article | 03/10/2018 |
| CEL deletion mutation increased endoplasmic reticulum stress, activated the unfolded protein response, and caused cell death by apoptosis in chronic pancreatitis. | A Carboxyl Ester Lipase (CEL) Mutant Causes Chronic Pancreatitis by Forming Intracellular Aggregates That Activate Apoptosis.
Xiao X, Jones G, Sevilla WA, Stolz DB, Magee KE, Haughney M, Mukherjee A, Wang Y, Lowe ME., Free PMC Article | 09/30/2017 |
| We could not demonstrate an association between CEL copy number variants and pancreatic cancer. An association is also unlikely for CEL variable number of tandem repeat lengths (VNTR), although analyses in larger materials are necessary to completely exclude an effect of rare VNTR alleles. | Copy number variants and VNTR length polymorphisms of the carboxyl-ester lipase (CEL) gene as risk factors in pancreatic cancer.
Dalva M, El Jellas K, Steine SJ, Johansson BB, Ringdal M, Torsvik J, Immervoll H, Hoem D, Laemmerhirt F, Simon P, Lerch MM, Johansson S, Njølstad PR, Weiss FU, Fjeld K, Molven A. | 08/12/2017 |
| The CEL gene harbours a variable number of tandem repeats (VNTR) region in exon 11. These results suggest that CEL VNTR lengths might associate with Alcoholic Liver Cirrhosis. | Length of Variable Numbers of Tandem Repeats in the Carboxyl Ester Lipase (CEL) Gene May Confer Susceptibility to Alcoholic Liver Cirrhosis but Not Alcoholic Chronic Pancreatitis.
Fjeld K, Beer S, Johnstone M, Zimmer C, Mössner J, Ruffert C, Krehan M, Zapf C, Njølstad PR, Johansson S, Bugert P, Miyajima F, Liloglou T, Brown LJ, Winn SA, Davies K, Latawiec D, Gunson BK, Criddle DN, Pirmohamed M, Grützmann R, Michl P, Greenhalf W, Molven A, Sutton R, Rosendahl J., Free PMC Article | 07/1/2017 |
| Data show that the c.1719C > T transition (single nucleotide polymorphism rs488087) present in bile salt-dependent lipase (BSDL) VNTR may be a useful marker for defining a population at risk of developing pancreatic cancer (PC) | Rs488087 single nucleotide polymorphism as predictive risk factor for pancreatic cancers.
Martinez E, Silvy F, Fina F, Bartoli M, Krahn M, Barlesi F, Figarella-Branger D, Iovanna J, Laugier R, Ouaissi M, Lombardo D, Mas E., Free PMC Article | 09/24/2016 |
| Expression of CEL-HYB in originating from a crossover between CEL and its neighboring pseudogene, CELP is associated with chronic pancreatitis. | A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis.
Fjeld K, Weiss FU, Lasher D, Rosendahl J, Chen JM, Johansson BB, Kirsten H, Ruffert C, Masson E, Steine SJ, Bugert P, Cnop M, Grützmann R, Mayerle J, Mössner J, Ringdal M, Schulz HU, Sendler M, Simon P, Sztromwasser P, Torsvik J, Scholz M, Tjora E, Férec C, Witt H, Lerch MM, Njølstad PR, Johansson S, Molven A., Free PMC Article | 07/25/2015 |
| secreted carboxyl ester lipase has a role in a syndrome of diabetes and pancreatic exocrine dysfunction | Endocytosis of secreted carboxyl ester lipase in a syndrome of diabetes and pancreatic exocrine dysfunction.
Torsvik J, Johansson BB, Dalva M, Marie M, Fjeld K, Johansson S, Bjørkøy G, Saraste J, Njølstad PR, Molven A., Free PMC Article | 12/27/2014 |
| CEL-MODY patients with a mutation in the variable number of tandem repeat region in exon 11 of the CEL gene displayed severely reduced acinar function and moderately reduced ductal function of the pancreas compared with control subjects. | Severe pancreatic dysfunction but compensated nutritional status in monogenic pancreatic disease caused by carboxyl-ester lipase mutations.
Tjora E, Wathle G, Engjom T, Erchinger F, Molven A, Aksnes L, Haldorsen IS, Dimcevski G, Njølstad PR, Ræder H. | 06/7/2014 |
| subjects with CEL-maturity-onset diabetes of the young develop multiple pancreatic cysts by the time they develop diabetes. upregulated MAPK signaling in the pancreas may reflect the pathophysiological development of pancreatic cysts and diabetes. | Carboxyl-ester lipase maturity-onset diabetes of the young is associated with development of pancreatic cysts and upregulated MAPK signaling in secretin-stimulated duodenal fluid.
Ræder H, McAllister FE, Tjora E, Bhatt S, Haldorsen I, Hu J, Willems SM, Vesterhus M, El Ouaamari A, Liu M, Ræder MB, Immervoll H, Hoem D, Dimcevski G, Njølstad PR, Molven A, Gygi SP, Kulkarni RN., Free PMC Article | 03/1/2014 |
| This study did not find evidence that supported an association between the common length variations of the CEL VNTR and chronic pancreatitis. | The number of tandem repeats in the carboxyl-ester lipase (CEL) gene as a risk factor in alcoholic and idiopathic chronic pancreatitis.
Ragvin A, Fjeld K, Weiss FU, Torsvik J, Aghdassi A, Mayerle J, Simon P, Njølstad PR, Lerch MM, Johansson S, Molven A. | 08/3/2013 |
| Monoclonal antibody 16D10 inhibits the proliferation of human pancreatic tumor cells expressing 16D10 plasma membrane antigen. | Targeting a novel onco-glycoprotein antigen at tumoral pancreatic cell surface by mAb16D10 induces cell death.
Crescence L, Beraud E, Sbarra V, Bernard JP, Lombardo D, Mas E. | 12/8/2012 |