| SLU7: A New Hub of Gene Expression Regulation-From Epigenetics to Protein Stability in Health and Disease. | SLU7: A New Hub of Gene Expression Regulation-From Epigenetics to Protein Stability in Health and Disease.
Gárate-Rascón M, Recalde M, Rojo C, Fernández-Barrena MG, Ávila MA, Arechederra M, Berasain C., Free PMC Article | 11/26/2022 |
| Splicing Factor SLU7 Prevents Oxidative Stress-Mediated Hepatocyte Nuclear Factor 4alpha Degradation, Preserving Hepatic Differentiation and Protecting From Liver Damage. | Splicing Factor SLU7 Prevents Oxidative Stress-Mediated Hepatocyte Nuclear Factor 4α Degradation, Preserving Hepatic Differentiation and Protecting From Liver Damage.
Gárate-Rascón M, Recalde M, Jimenez M, Elizalde M, Azkona M, Uriarte I, Latasa MU, Urtasun R, Bilbao I, Sangro B, Garcia-Ruiz C, Fernandez-Checa JC, Corrales FJ, Esquivel A, Pineda-Lucena A, Fernández-Barrena MG, Ávila MA, Arechederra M, Berasain C. | 01/15/2022 |
| The splicing regulator SLU7 is required to preserve DNMT1 protein stability and DNA methylation. | The splicing regulator SLU7 is required to preserve DNMT1 protein stability and DNA methylation.
Recalde M, Gárate-Rascón M, Elizalde M, Azkona M, Latasa MU, Bárcena-Varela M, Sangro B, Fernández-Barrena MG, Ávila MA, Arechederra M, Berasain C., Free PMC Article | 11/6/2021 |
| We define a molecular pathway through which SLU7 keeps in check the generation of truncated forms of the splicing factor SRSF3 (SRp20) (SRSF3-TR). Behaving as dominant negative, or by gain-of-function, SRSF3-TR impair the correct splicing and expression of the splicing regulator SRSF1 (ASF/SF2) and the crucial SCC protein sororin. | Splicing events in the control of genome integrity: role of SLU7 and truncated SRSF3 proteins.
Jiménez M, Urtasun R, Elizalde M, Azkona M, Latasa MU, Uriarte I, Arechederra M, Alignani D, Bárcena-Varela M, Álvarez-Sola G, Colyn L, Santamaría E, Sangro B, Rodriguez-Ortigosa C, Fernández-Barrena MG, Ávila MA, Berasain C., Free PMC Article | 10/12/2019 |
| High SLU7 expression is associated with alcoholic steatohepatitis. | Hepatic Knockdown of Splicing Regulator Slu7 Ameliorates Inflammation and Attenuates Liver Injury in Ethanol-Fed Mice.
Wang J, Kainrad N, Shen H, Zhou Z, Rote P, Zhang Y, Nagy LE, Wu J, You M., Free PMC Article | 07/13/2019 |
| these findings indicate that SLU7 is co-opted by hepatocellular carcinoma (HCC) cells and other tumor cell types to maintain survival, and identify this splicing regulator as a new determinant for the expression of the oncogenic miR-17-92 cluster. This novel mechanism may be exploited for the development of antitumoral strategies in cancers displaying such SLU7-miR-17-92 crosstalk | Splicing regulator SLU7 preserves survival of hepatocellular carcinoma cells and other solid tumors via oncogenic miR-17-92 cluster expression.
Urtasun R, Elizalde M, Azkona M, Latasa MU, García-Irigoyen O, Uriarte I, Fernández-Barrena MG, Vicent S, Alonso MM, Muntané J, Prieto J, Ávila MA, Berasain C. | 09/2/2017 |
| SLU7 knockdown in liver cells resulted in profound changes in pre-mRNA splicing and gene expression, leading to impaired glucose and lipid metabolism, refractoriness to key metabolic hormones, and reversion to a fetal-like gene expression pattern. | Splicing regulator SLU7 is essential for maintaining liver homeostasis.
Elizalde M, Urtasun R, Azkona M, Latasa MU, Goñi S, García-Irigoyen O, Uriarte I, Segura V, Collantes M, Di Scala M, Lujambio A, Prieto J, Ávila MA, Berasain C., Free PMC Article | 10/11/2014 |
| These observations together point to an altered recruitment and dependence on SLU7, suggesting its role in facilitating transitions that promote catalysis, and highlight the diversity in spliceosome assembly. | Splicing functions and global dependency on fission yeast slu7 reveal diversity in spliceosome assembly.
Banerjee S, Khandelia P, Melangath G, Bashir S, Nagampalli V, Vijayraghavan U., Free PMC Article | 10/26/2013 |
| RBM22 and hSlu7 differ significantly in their subcellular distributions under stress conditions, and RBM22 enhances the cytoplasmic translocation of hSlu7 under stress. | Stress induced subcellular distribution of ALG-2, RBM22 and hSlu7.
Janowicz A, Michalak M, Krebs J. | 07/23/2011 |
| Regulation of transcription of the RNA splicing factor hSlu7 by Elk-1 and Sp1 affects alternative splicing | Regulation of transcription of the RNA splicing factor hSlu7 by Elk-1 and Sp1 affects alternative splicing.
Alberstein M, Amit M, Vaknin K, O'Donnell A, Farhy C, Lerenthal Y, Shomron N, Shaham O, Sharrocks AD, Ashery-Padan R, Ast G., Free PMC Article | 01/21/2010 |
| The zinc-knuckle motif of hSlu7 determines the cellular localization of the protein through a nucleocytoplasmic-sensitive shuttling balance. | Splicing factor hSlu7 contains a unique functional domain required to retain the protein within the nucleus.
Shomron N, Reznik M, Ast G., Free PMC Article | 01/21/2010 |
| hSlu7 has a broad effect on alternative splicing | Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing.
Shomron N, Alberstein M, Reznik M, Ast G. | 01/21/2010 |