| Pre-rRNA facilitates the recruitment of RAD51AP1 to DNA double-strand breaks. | Pre-rRNA facilitates the recruitment of RAD51AP1 to DNA double-strand breaks.
Chen L, Gai X, Yu X., Free PMC Article | 04/5/2024 |
| The gene RAD51AP1 promotes the progression of pancreatic cancer via the PI3K/Akt/NF-kappaB signaling pathway. | The gene RAD51AP1 promotes the progression of pancreatic cancer via the PI3K/Akt/NF-κB signaling pathway.
Wang Y, Li Y, Ran C, Le W, Dong J, Wang X, Chen B, Jiang X. | 02/2/2024 |
| Identification of the E2F1-RAD51AP1 axis as a key factor in MGMT-methylated GBM TMZ resistance. | Identification of the E2F1-RAD51AP1 axis as a key factor in MGMT-methylated GBM TMZ resistance.
Zhou J, Tong F, Zhao J, Cui X, Wang Y, Wang G, Kang C, Liu X, Wang Q., Free PMC Article | 06/9/2023 |
| RAD51AP1 Loss Attenuates Colorectal Cancer Stem Cell Renewal and Sensitizes to Chemotherapy. | RAD51AP1 Loss Attenuates Colorectal Cancer Stem Cell Renewal and Sensitizes to Chemotherapy.
Bridges AE, Ramachandran S, Tamizhmani K, Parwal U, Lester A, Rajpurohit P, Morera DS, Hasanali SL, Arjunan P, Jedeja RN, Patel N, Martin PM, Korkaya H, Singh N, Manicassamy S, Prasad PD, Lokeshwar VB, Lokeshwar BL, Ganapathy V, Thangaraju M., Free PMC Article | 02/12/2022 |
| A Novel Neoplastic Fusion Transcript, RAD51AP1-DYRK4, Confers Sensitivity to the MEK Inhibitor Trametinib in Aggressive Breast Cancers. | A Novel Neoplastic Fusion Transcript, RAD51AP1-DYRK4, Confers Sensitivity to the MEK Inhibitor Trametinib in Aggressive Breast Cancers.
Liu CC, Veeraraghavan J, Tan Y, Kim JA, Wang X, Loo SK, Lee S, Hu Y, Wang XS., Free PMC Article | 01/22/2022 |
| ZEB1 induces non-small cell lung cancer development by targeting microRNA-320a to increase the expression of RAD51AP1. | ZEB1 induces non-small cell lung cancer development by targeting microRNA-320a to increase the expression of RAD51AP1.
Wang H, Dong H, Qiao L, Wu Y, Wu B, Jin X. | 10/16/2021 |
| RAD51AP1 promotes progression of ovarian cancer via TGF-beta/Smad signalling pathway. | RAD51AP1 promotes progression of ovarian cancer via TGF-β/Smad signalling pathway.
Zhao H, Gao Y, Chen Q, Li J, Ren M, Zhao X, Yue W., Free PMC Article | 09/25/2021 |
| RAD51AP1 mediates RAD51 activity through nucleosome interaction. | RAD51AP1 mediates RAD51 activity through nucleosome interaction.
Pires E, Sharma N, Selemenakis P, Wu B, Huang Y, Alimbetov DS, Zhao W, Wiese C., Free PMC Article | 08/28/2021 |
| NUCKS1 promotes RAD54 activity in homologous recombination DNA repair. | NUCKS1 promotes RAD54 activity in homologous recombination DNA repair.
Maranon DG, Sharma N, Huang Y, Selemenakis P, Wang M, Altina N, Zhao W, Wiese C., Free PMC Article | 03/28/2021 |
| High RAD51AP1 expression is associated with epithelial-mesenchymal transition and metastasis in non-small cell lung cancer. | Silencing of RAD51AP1 suppresses epithelial-mesenchymal transition and metastasis in non-small cell lung cancer.
Wu Y, Wang H, Qiao L, Jin X, Dong H, Wang Y., Free PMC Article | 08/13/2020 |
| RAD51AP1 is an essential mediator of the alternative lengthening of telomeres (ALT) mechanism and is co-opted by post-translational mechanisms to maintain telomere length and ensure proliferation of ALT+ cancer cells. | RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres.
Barroso-González J, García-Expósito L, Hoang SM, Lynskey ML, Roncaioli JL, Ghosh A, Wallace CT, de Vitis M, Modesti M, Bernstein KA, Sarkar SN, Watkins SC, O'Sullivan RJ., Free PMC Article | 02/22/2020 |
| RAD51AP1 upregulation is described in both tissue and matching blood from patients with ovarian and lung cancer compared with healthy controls. | Identification of cancer biomarkers of prognostic value using specific gene regulatory networks (GRN): a novel role of RAD51AP1 for ovarian and lung cancers.
Chudasama D, Bo V, Hall M, Anikin V, Jeyaneethi J, Gregory J, Pados G, Tucker A, Harvey A, Pink R, Karteris E., Free PMC Article | 11/3/2018 |
| The current understanding of the biochemical and biological functions of RAD51AP1 as HR factor is reviewed. It is also discussed how RAD51AP1 may help to promote cancer development and potentially be a promising new target for therapeutic intervention. [REVIEW] | Role of RAD51AP1 in homologous recombination DNA repair and carcinogenesis.
Pires E, Sung P, Wiese C., Free PMC Article | 12/2/2017 |
| USP1-UAF1 complex promotes homologous recombination repair via multiple mechanisms: through FANCD2 deubiquitination, as well as by interacting with RAD51AP1. | The USP1-UAF1 complex interacts with RAD51AP1 to promote homologous recombination repair.
Cukras S, Lee E, Palumbo E, Benavidez P, Moldovan GL, Kee Y., Free PMC Article | 06/24/2017 |
| RAD51AP1 is required for the maintenance of DNA replication fork progression. | RAD51AP1-deficiency in vertebrate cells impairs DNA replication.
Parplys AC, Kratz K, Speed MC, Leung SG, Schild D, Wiese C., Free PMC Article | 10/24/2015 |
| Data suggest that microRNA/mRNA pairs in hsa-miR-140-3p/RAD51AP1/, hsa-miR-145/E2F3, hsa-miR-139-5p/TOP2A, and hsa-miR-133a/GCLC were correlated with ovarian tumorigenesis. | Identifying microRNA/mRNA dysregulations in ovarian cancer.
Miles GD, Seiler M, Rodriguez L, Rajagopal G, Bhanot G., Free PMC Article | 03/2/2013 |
| We have finely mapped the two DNA binding domains in RAD51AP1 and using mutant variants, reveal that both domains are indispensable for RAD51AP1 function in cells. | Mechanistic insights into RAD51-associated protein 1 (RAD51AP1) action in homologous DNA repair.
Dunlop MH, Dray E, Zhao W, San Filippo J, Tsai MS, Leung SG, Schild D, Wiese C, Sung P., Free PMC Article | 06/9/2012 |
| RAD51-associated protein 1 (RAD51AP1) interacts with the meiotic recombinase DMC1 through a conserved motif. | RAD51-associated protein 1 (RAD51AP1) interacts with the meiotic recombinase DMC1 through a conserved motif.
Dunlop MH, Dray E, Zhao W, Tsai MS, Wiese C, Schild D, Sung P., Free PMC Article | 12/17/2011 |
| RAD51AP1 foci colocalize with a subset of DMC1 foci in spermatocytes. | Molecular basis for enhancement of the meiotic DMC1 recombinase by RAD51 associated protein 1 (RAD51AP1).
Dray E, Dunlop MH, Kauppi L, San Filippo J, Wiese C, Tsai MS, Begovic S, Schild D, Jasin M, Keeney S, Sung P., Free PMC Article | 05/14/2011 |
| Although PALB2 alone stimulates D-loop formation, it has a cooperative effect with RAD51AP1, an enhancer of RAD51. | Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2.
Dray E, Etchin J, Wiese C, Saro D, Williams GJ, Hammel M, Yu X, Galkin VE, Liu D, Tsai MS, Sy SM, Schild D, Egelman E, Chen J, Sung P., Free PMC Article | 11/27/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Human variation in alcohol response is influenced by variation in neuronal signaling genes.
Joslyn G, Ravindranathan A, Brush G, Schuckit M, White RL. | 04/7/2010 |
| Enhanced expression of RAD51 associating protein-1 is involved in the growth of intrahepatic cholangiocarcinoma | Enhanced expression of RAD51 associating protein-1 is involved in the growth of intrahepatic cholangiocarcinoma cells.
Obama K, Satoh S, Hamamoto R, Sakai Y, Nakamura Y, Furukawa Y. | 01/21/2010 |
| RAD51AP1 helps maintain genomic integrity via RAD51 recombinase enhancement. | Promotion of homologous recombination and genomic stability by RAD51AP1 via RAD51 recombinase enhancement.
Wiese C, Dray E, Groesser T, San Filippo J, Shi I, Collins DW, Tsai MS, Williams GJ, Rydberg B, Sung P, Schild D., Free PMC Article | 01/21/2010 |
| RAD51AP1 has a selective affinity for branched-DNA structures that are obligatory intermediates during joint molecule formation. | RAD51AP1 is a structure-specific DNA binding protein that stimulates joint molecule formation during RAD51-mediated homologous recombination.
Modesti M, Budzowska M, Baldeyron C, Demmers JA, Ghirlando R, Kanaar R. | 01/21/2010 |
| expression of three (Beclin 1, RbAp48 and Pir51) were increased and one (aldolase b) was decreased in liver tumor tissues | Genes encoding Pir51, Beclin 1, RbAp48 and aldolase b are up or down-regulated in human primary hepatocellular carcinoma.
Song H, Xia SL, Liao C, Li YL, Wang YF, Li TP, Zhao MJ., Free PMC Article | 01/21/2010 |