| KHDRBS1 as a novel prognostic signaling biomarker influencing hepatocellular carcinoma cell proliferation, migration, immune microenvironment, and drug sensitivity. | KHDRBS1 as a novel prognostic signaling biomarker influencing hepatocellular carcinoma cell proliferation, migration, immune microenvironment, and drug sensitivity.
Fan R, Liu F, Gong Q, Liu D, Tang S, Shen D., Free PMC Article | 05/8/2024 |
| Sam68 is a druggable vulnerability point in cancer stem cells. | Sam68 is a druggable vulnerability point in cancer stem cells.
da Silva AM, Yevdokimova V, Benoit YD., Free PMC Article | 04/17/2024 |
| Cdk1-mediated threonine phosphorylation of Sam68 modulates its RNA binding, alternative splicing activity and cellular functions. | Cdk1-mediated threonine phosphorylation of Sam68 modulates its RNA binding, alternative splicing activity and cellular functions.
Malki I, Liepina I, Kogelnik N, Watmuff H, Robinson S, Lightfoot A, Gonchar O, Bottrill A, Fry AM, Dominguez C., Free PMC Article | 01/21/2023 |
| The transcriptional terminator XRN2 and the RNA-binding protein Sam68 link alternative polyadenylation to cell cycle progression in prostate cancer. | The transcriptional terminator XRN2 and the RNA-binding protein Sam68 link alternative polyadenylation to cell cycle progression in prostate cancer.
Pieraccioli M, Caggiano C, Mignini L, Zhong C, Babini G, Lattanzio R, Di Stasi S, Tian B, Sette C, Bielli P., Free PMC Article | 11/19/2022 |
| Decreased Expression of Sam68 Is Associated with Insulin Resistance in Granulosa Cells from PCOS Patients. | Decreased Expression of Sam68 Is Associated with Insulin Resistance in Granulosa Cells from PCOS Patients.
Vilariño-García T, Guadix P, Dorado-Silva M, Sánchez-Martín P, Pérez-Pérez A, Sánchez-Margalet V., Free PMC Article | 10/8/2022 |
| High expression of Sam68 contributes to metastasis by regulating vimentin expression and a motile phenotype in oral squamous cell carcinoma. | High expression of Sam68 contributes to metastasis by regulating vimentin expression and a motile phenotype in oral squamous cell carcinoma.
Komiyama T, Kuroshima T, Sugasawa T, Fujita SI, Ikami Y, Hirai H, Tsushima F, Michi Y, Kayamori K, Higashino F, Harada H., Free PMC Article | 09/24/2022 |
| Effective targeting of breast cancer stem cells by combined inhibition of Sam68 and Rad51. | Effective targeting of breast cancer stem cells by combined inhibition of Sam68 and Rad51.
Turdo A, Gaggianesi M, Di Franco S, Veschi V, D'Accardo C, Porcelli G, Lo Iacono M, Pillitteri I, Verona F, Militello G, Zippo A, Poli V, Fagnocchi L, Beyes S, Stella S, Lattanzio R, Faldetta N, Lentini VL, Porcasi R, Pistone G, Bongiorno MR, Stassi G, De Maria R, Todaro M., Free PMC Article | 04/16/2022 |
| Distinct RNA polymerase transcripts direct the assembly of phase-separated DBC1 nuclear bodies in different cell lines. | Distinct RNA polymerase transcripts direct the assembly of phase-separated DBC1 nuclear bodies in different cell lines.
Mannen T, Goto M, Yoshizawa T, Yamashita A, Hirose T, Hayano T., Free PMC Article | 03/26/2022 |
| Sam68 contributes to intestinal inflammation in experimental and human colitis. | Sam68 contributes to intestinal inflammation in experimental and human colitis.
Goodman WA, Basavarajappa SC, Liu AR, Rodriguez FDS, Mathes T, Ramakrishnan P., Free PMC Article | 12/11/2021 |
| Differential regulation of a placental SAM68 and sFLT1 gene pathway and the relevance to maternal vitamin D sufficiency. | Differential regulation of a placental SAM68 and sFLT1 gene pathway and the relevance to maternal vitamin D sufficiency.
Awe O, Sinkway JM, Chow RP, Wagener Q, Schulz EV, Yu JY, Nietert PJ, Wagner CL, Lee KH., Free PMC Article | 08/14/2021 |
| Antibody-based biosensor to detect oncogenic splicing factor Sam68 for the diagnosis of lung cancer. | Antibody-based biosensor to detect oncogenic splicing factor Sam68 for the diagnosis of lung cancer.
Sumithra B, Jayanthi VSPKSA, Manne HC, Gunda R, Saxena U, Das AB. | 07/31/2021 |
| SAM68 promotes tumorigenesis in lung adenocarcinoma by regulating metabolic conversion via PKM alternative splicing. | SAM68 promotes tumorigenesis in lung adenocarcinoma by regulating metabolic conversion via PKM alternative splicing.
Zhu S, Chen W, Wang J, Qi L, Pan H, Feng Z, Tian D., Free PMC Article | 07/24/2021 |
| Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified. | Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified.
Debackere K, Marcelis L, Demeyer S, Vanden Bempt M, Mentens N, Gielen O, Jacobs K, Broux M, Verhoef G, Michaux L, Graux C, Wlodarska I, Gaulard P, de Leval L, Tousseyn T, Cools J, Dierickx D., Free PMC Article | 07/10/2021 |
| Sam68 promotes hepatic gluconeogenesis via CRTC2. | Sam68 promotes hepatic gluconeogenesis via CRTC2.
Qiao A, Zhou J, Xu S, Ma W, Boriboun C, Kim T, Yan B, Deng J, Yang L, Zhang E, Song Y, Ma YC, Richard S, Zhang C, Qiu H, Habegger KM, Zhang J, Qin G., Free PMC Article | 06/26/2021 |
| Sam68 Promotes the Progression of Human Breast Cancer through inducing Activation of EphA3. | Sam68 Promotes the Progression of Human Breast Cancer through inducing Activation of EphA3.
Chen X, Zhang L, Yuan M, Kuang Z, Zou Y, Tang T, Zhang W, Hu X, Xia T, Cao T, Jia H. | 05/15/2021 |
| ITSN1 regulates SAM68 solubility through SH3 domain interactions with SAM68 proline-rich motifs. | ITSN1 regulates SAM68 solubility through SH3 domain interactions with SAM68 proline-rich motifs.
Pankivskyi S, Pastré D, Steiner E, Joshi V, Rynditch A, Hamon L., Free PMC Article | 03/6/2021 |
| A comprehensive study on genome-wide coexpression network of KHDRBS1/Sam68 reveals its cancer and patient-specific association. | A comprehensive study on genome-wide coexpression network of KHDRBS1/Sam68 reveals its cancer and patient-specific association.
Sumithra B, Saxena U, Das AB., Free PMC Article | 10/24/2020 |
| This study discloses a new host factor that binds to the HCV 5' UTR and promotes HCV replication. Sam68 may play an important role in HCV-related diseases, and further investigation is highly encouraged to explore its specific actions in HCV pathogenesis. | Sam68 Promotes Hepatitis C Virus Replication by Interaction with Stem-Loop 2 of Viral 5' Untranslated Region.
Qin Y, Xun Z, Guo Y, Chen S, Zhu H., Free PMC Article | 05/30/2020 |
| Studies uncover a fine-tuned modulation of the proto-oncogene CCND1 in Ewing sarcoma cells via alternative complexes formed by DHX9 with either EWS-FLI1 or pncCCND1_B-Sam68. | The Promoter-Associated Noncoding RNA pncCCND1_B Assembles a Protein-RNA Complex to Regulate Cyclin D1 Transcription in Ewing Sarcoma.
Palombo R, Frisone P, Fidaleo M, Mercatelli N, Sette C, Paronetto MP. | 04/11/2020 |
| Bioinformatics analyses revealed the presence of ultra-conserved Sam68 binding sites in SMN IRAlus. Cross-link-immunoprecipitation (CLIP), mutagenesis and silencing experiments showed that Sam68 binds in proximity of intronic Alus in the SMN pre-mRNA, thus favouring circRNA biogenesis in vitro and in vivo. | Sam68 binds Alu-rich introns in SMN and promotes pre-mRNA circularization.
Pagliarini V, Jolly A, Bielli P, Di Rosa V, De la Grange P, Sette C., Free PMC Article | 03/21/2020 |
| Study uncover an unexpected coordination of transcription and splicing of Sam68 by c-MYC, which may represent a key step in prostate cancer tumorigenesis. | c-MYC empowers transcription and productive splicing of the oncogenic splicing factor Sam68 in cancer.
Caggiano C, Pieraccioli M, Panzeri V, Sette C, Bielli P., Free PMC Article | 02/29/2020 |
| study illustrates a novel mechanism of p68 mediated deployment of beta-catenin in RelA gene regulation eventually leading to activation and recruitment of NF-kappaB signaling axis in the cell survival pathway for promoting tumorigenesis. | RNA helicase p68 deploys β-catenin in regulating RelA/p65 gene expression: implications in colon cancer.
Khare V, Tabassum S, Chatterjee U, Chatterjee S, Ghosh MK., Free PMC Article | 01/11/2020 |
| NCL and Sam68 could recognize their specific motifs and directly bind to EXON1 of CYTOR. Moreover, EXON1 was the key functional site mediating the interaction of CYTOR with NCL and Sam68. NCL and Sam68 functioned as oncogenes to promote colorectal cancer (CRC) progression. Further results confirmed that the heterotrimeric complex of CYTOR, NCL and Sam68 activated the NF-kappaB pathway and EMT to contribute to CRC progr... | The long non-coding RNA CYTOR drives colorectal cancer progression by interacting with NCL and Sam68.
Wang X, Yu H, Sun W, Kong J, Zhang L, Tang J, Wang J, Xu E, Lai M, Zhang H., Free PMC Article | 03/23/2019 |
| Vimentin and Sam68, are identified as bona fide SRMS substrates through in vitro and in vivo assays. | Phosphoproteomics Analysis Identifies Novel Candidate Substrates of the Nonreceptor Tyrosine Kinase, Src-related Kinase Lacking C-terminal Regulatory Tyrosine and N-terminal Myristoylation Sites (SRMS).
Goel RK, Paczkowska M, Reimand J, Napper S, Lukong KE., Free PMC Article | 03/9/2019 |
| Case Report: congenital CD34-positive dermohypodermal spindle-cell neoplasm occurring in a female infant and harboring a novel KHDRBS1-NTRK3 fusion. | Novel KHDRBS1-NTRK3 rearrangement in a congenital pediatric CD34-positive skin tumor: a case report.
Tallegas M, Fraitag S, Binet A, Orbach D, Jourdain A, Reynaud S, Pierron G, Machet MC, Maruani A. | 02/2/2019 |